(Q44621428)

English

Cytotoxic iron chelators: characterization of the structure, solution chemistry and redox activity of ligands and iron complexes of the di-2-pyridyl ketone isonicotinoyl hydrazone (HPKIH) analogues

scientific article published on 15 October 2003

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

Cytotoxic iron chelators: characterization of the structure, solution chemistry and redox activity of ligands and iron complexes of the di-2-pyridyl ketone isonicotinoyl hydrazone (HPKIH) analogues (English)

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

0 references

Des R. Richardson

5

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

author name string

Paul V Bernhardt

1

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

Lorraine M Caldwell

2

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

Timothy B Chaston

3

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

Piao Chin

4

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

publication date

15 October 2003

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Europe PubMed Central

PubMed publication ID

4 December 2017

Journal of Biological Inorganic Chemistry

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Europe PubMed Central

PubMed publication ID

4 December 2017

8

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

8

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

866-880

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

In vivo formation of single-strand breaks in DNA by hydrogen peroxide is mediated by the Haber-Weiss reaction

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Anthracycline-derived chemotherapeutics in apoptosis and free radical cytotoxicity (Review)

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Synthesis, structure, and biological activity of organotin compounds with di-2-pyridylketone and phenyl(2-pyridyl) ketone 2-aminobenzoylhydrazones.

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Synergistic inhibition of lymphoid tumor growth in vitro by combined treatment with the iron chelator deferoxamine and an immunoglobulin G monoclonal antibody against the transferrin receptor.

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Interactions of the pyridine-2-carboxaldehyde isonicotinoyl hydrazone class of chelators with iron and DNA: implications for toxicity in the treatment of iron overload disease

1 reference

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Treatment with deferoxamine during ischemia improves functional and metabolic recovery and reduces reperfusion-induced oxygen radical generation in rabbit hearts

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Di-2-pyridyl ketone p-aminobenzoylhydrazone hydrate

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Oxidative destruction of DNA by the adriamycin-iron complex.

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Iron chelators as therapeutic agents for the treatment of cancer.

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Oxidative DNA damage mediated by copper(II), iron(II) and nickel(II) Fenton reactions: evidence for site-specific mechanisms in the formation of double-strand breaks, 8-hydroxydeoxyguanosine and putative intrastrand cross-links

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Unprecedented oxidation of a biologically active aroylhydrazone chelator catalysed by iron(III): serendipitous identification of diacylhydrazine ligands with high iron chelation efficacy

1 reference

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Analogues of pyridoxal isonicotinoyl hydrazone (PIH) as potential iron chelators for the treatment of neoplasia

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Iron chelators as anti-neoplastic agents: current developments and promise of the PIH class of chelators

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The stability constants of copper(II) complexes with some alpha-amino acids in dioxan-water mixtures

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Crystal and molecular structure of 2-hydroxy-1-naphthaldehyde isonicotinoyl hydrazone (NIH) and its iron(III) complex: an iron chelator with anti-tumour activity

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Iron chelation and hydroxyl radical scavenging reduce the inflammatory response of endothelial cells after infection with Chlamydia pneumoniae or influenza A.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14564555

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Demonstration of nitrogen coordination in metal-bleomycin complexes by electron spin-echo envelope spectroscopy

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Identification of the di-pyridyl ketone isonicotinoyl hydrazone (PKIH) analogues as potent iron chelators and anti-tumour agents

1 reference

https://pubmed.ncbi.nlm.nih.gov/14564555

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The iron chelator pyridoxal isonicotinoyl hydrazone (PIH) protects plasmid pUC-18 DNA against *OH-mediated strand breaks

1 reference

https://pubmed.ncbi.nlm.nih.gov/14564555

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Superoxide-dependent formation of hydroxyl radicals from ferric-complexes and hydrogen peroxide: an evaluation of fourteen iron chelators

1 reference

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Crystal structure of ferrioxamine B: a comparative analysis and implications for molecular recognition

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A simple and very sensitive spectrophotometric method for the direct determination of copper ions

1 reference

https://pubmed.ncbi.nlm.nih.gov/14564555

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The action of nine chelators on iron-dependent radical damage

1 reference

https://pubmed.ncbi.nlm.nih.gov/14564555

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Pyridoxal isonicotinoyl hydrazone and its analogs: potential orally effective iron-chelating agents for the treatment of iron overload disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/14564555

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Development of potential iron chelators for the treatment of Friedreich's ataxia: ligands that mobilize mitochondrial iron

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The iron paradox of heart and lungs and its implications for acute lung injury.

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The potential of iron chelators of the pyridoxal isonicotinoyl hydrazone class as effective antiproliferative agents

1 reference

https://pubmed.ncbi.nlm.nih.gov/14564555

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Iron ion-dependent modification of bases in DNA by the superoxide radical-generating system hypoxanthine/xanthine oxidase

1 reference

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The potential of iron chelators of the pyridoxal isonicotinoyl hydrazone class as effective antiproliferative agents II: the mechanism of action of ligands derived from salicylaldehyde benzoyl hydrazone and 2-hydroxy-1-naphthylaldehyde benzoyl hydra

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Identifiers

10.1007/S00775-003-0486-Z

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

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