(Q44675700)

English

Glutamate uptake inhibitor L-trans-pyrrolidine 2,4-dicarboxylate becomes neurotoxic in the presence of subthreshold concentrations of mitochondrial toxin 3-nitropropionate: involvement of mitochondrial reducing activity and ATP production

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Europe PubMed Central

PubMed publication ID

5 December 2017

Glutamate uptake inhibitor L-trans-pyrrolidine 2,4-dicarboxylate becomes neurotoxic in the presence of subthreshold concentrations of mitochondrial toxin 3-nitropropionate: involvement of mitochondrial reducing activity and ATP production (English)

1 reference

Europe PubMed Central

PubMed publication ID

5 December 2017

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Octavio García

1

1 reference

Europe PubMed Central

PubMed publication ID

5 December 2017

Lourdes Massieu

2

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Europe PubMed Central

PubMed publication ID

5 December 2017

publication date

1 December 2003

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Europe PubMed Central

PubMed publication ID

5 December 2017

Journal of Neuroscience Research

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Europe PubMed Central

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5 December 2017

74

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Europe PubMed Central

PubMed publication ID

5 December 2017

6

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Europe PubMed Central

PubMed publication ID

5 December 2017

956-966

1 reference

Europe PubMed Central

PubMed publication ID

5 December 2017

A transient inhibition of mitochondrial ATP synthesis by nitric oxide synthase activation triggered apoptosis in primary cortical neurons.

1 reference

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Glutamate-induced neuronal death: A succession of necrosis or apoptosis depending on mitochondrial function

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beta-Amyloid neurotoxicity is exacerbated during glycolysis inhibition and mitochondrial impairment in the rat hippocampus in vivo and in isolated nerve terminals: implications for Alzheimer's disease

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Energetics in the pathogenesis of neurodegenerative diseases

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Elevation of the Extracellular Concentrations of Glutamate and Aspartate in Rat Hippocampus During Transient Cerebral Ischemia Monitored by Intracerebral Microdialysis

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Mitochondrial and nonmitochondrial reduction of MTT: interaction of MTT with TMRE, JC-1, and NAO mitochondrial fluorescent probes.

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Characterization of the cellular reduction of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT): subcellular localization, substrate dependence, and involvement of mitochondrial electron transport in MTT reduction

1 reference

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Chromatin condensation during glutamate-induced excitotoxicity of cerebellar [correction of celebellar] granule neurons precedes disintegration of nuclear DNA into high molecular weight DNA fragments

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21 January 2018

Glutamate in neurologic diseases

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The glutamate transport inhibitor L-trans-pyrrolidine-2,4-dicarboxylate indirectly evokes NMDA receptor mediated neurotoxicity in rat cortical cultures.

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21 January 2018

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

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Conformationally defined neurotransmitter analogs. Selective inhibition of glutamate uptake by one pyrrolidine-2,4-dicarboxylate diastereomer

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Prolonged inhibition of glutamate reuptake down-regulates NMDA receptor functions in cultured cerebellar granule cells.

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Reactive oxygen radicals in signaling and damage in the ischemic brain

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Micromolar L-glutamate induces extensive apoptosis in an apoptotic-necrotic continuum of insult-dependent, excitotoxic injury in cultured cortical neurones.

1 reference

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Ischemia-induced neuronal apoptosis

1 reference

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Characterization of transient focal ischemia-induced increases in extracellular glutamate and aspartate in spontaneously hypertensive rats.

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Mitochondria in neurodegeneration: acute ischemia and chronic neurodegenerative diseases

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Strategies for neuroprotection against L-trans-2,4-pyrrolidine dicarboxylate-induced neuronal damage during energy impairment in vitro

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Programmed cell death in cerebral ischemia

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The mitochondrial pyruvate carrier. Kinetics and specificity for substrates and inhibitors

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Oxidative neuronal death caused by glutamate uptake inhibition in cultured hippocampal neurons

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NMDA-dependent superoxide production and neurotoxicity.

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21 January 2018

The mechanisms of neuronal death produced by mitochondrial toxin 3-nitropropionic acid: the roles of N-methyl-D-aspartate glutamate receptors and mitochondrial calcium overload.

1 reference

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21 January 2018

Acute and chronic alterations in calcium homeostasis in 3-nitropropionic acid-treated human NT2-N neurons.

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K(+)-induced reversal of astrocyte glutamate uptake is limited by compensatory changes in intracellular Na+.

1 reference

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Neurodegeneration in excitotoxicity, global cerebral ischemia, and target deprivation: A perspective on the contributions of apoptosis and necrosis.

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21 January 2018

Neurotoxicity of glutamate uptake inhibition in vivo: correlation with succinate dehydrogenase activity and prevention by energy substrates

1 reference

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Acetoacetate protects hippocampal neurons against glutamate-mediated neuronal damage during glycolysis inhibition.

1 reference

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21 January 2018

Pyruvate and lactate protect striatal neurons against N-methyl-D-aspartate-induced neurotoxicity

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Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

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Influence of cytosolic and mitochondrial Ca2+, ATP, mitochondrial membrane potential, and calpain activity on the mechanism of neuron death induced by 3-nitropropionic acid

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21 January 2018

Evidence for hypoxia-induced, programmed cell death of cultured neurons

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Glutamate release in severe brain ischaemia is mainly by reversed uptake.

1 reference

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Transient inhibition of glutamate uptake in vivo induces neurodegeneration when energy metabolism is impaired.

1 reference

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21 January 2018

Inhibition of ischemia-induced glutamate release in rat striatum by dihydrokinate and an anion channel blocker.

1 reference

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21 January 2018

Blockade of N -Methyl-D-Aspartate Receptors May Protect Against Ischemic Damage in the Brain

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Effect of beta-hydroxybutyrate, a cerebral function improving agent, on cerebral hypoxia, anoxia and ischemia in mice and rats

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Glutamate-induced mitochondrial depolarisation and perturbation of calcium homeostasis in cultured rat hippocampal neurones

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The competitive transport inhibitor L-trans-pyrrolidine-2, 4-dicarboxylate triggers excitotoxicity in rat cortical neuron-astrocyte co-cultures via glutamate release rather than uptake inhibition.

1 reference

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Effect of peroxynitrite on the mitochondrial respiratory chain: differential susceptibility of neurones and astrocytes in primary culture

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Inhibition of mitochondrial ATP generation by nitric oxide switches apoptosis to necrosis

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Mechanism of cellular 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) reduction.

1 reference

https://api.crossref.org/works/10.1002%2FJNR.10825

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Determination of intracellular ATP in primary cultures of neurons

1 reference

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In vivo potentiation of glutamate-mediated neuronal damage after chronic administration of the glycolysis inhibitor iodoacetate

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Accumulation of extracellular glutamate by inhibition of its uptake is not sufficient for inducing neuronal damage: an in vivo microdialysis study

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21 January 2018

Identifiers

10.1002/JNR.10825

1 reference

Europe PubMed Central

PubMed publication ID

5 December 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

5 December 2017

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