(Q44697387)

5 December 2017

title

Feed-forward regulation of bile acid detoxification by CYP3A4: studies in humanized transgenic mice (English)

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5 December 2017

1

Catherine Stedman

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5 December 2017

Graham Robertson

2

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5 December 2017

Sally Coulter

series ordinal

3

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5 December 2017

Christopher Liddle

series ordinal

4

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5 December 2017

language of work or name

English

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publication date

17 December 2003

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Journal of Biological Chemistry

5 December 2017

published in

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5 December 2017

volume

279

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5 December 2017

issue

12

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5 December 2017

page(s)

11336-11343

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5 December 2017

cites work

Bile acid biosynthesis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310258200

The lithocholic acid 6 beta-hydroxylase cytochrome P-450, CYP 3A10, is an active catalyst of steroid-hormone 6 beta-hydroxylation

21 January 2018

1 reference

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An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310258200

Analysis of plasma bile acid profiles in patients with liver diseases associated with cholestasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310258200

Identification of bile acids in the serum and urine in cholestasis. Evidence for 6alpha-hydroxylation of bile acids in man

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310258200

6alpha-hydroxylation of taurochenodeoxycholic acid and lithocholic acid by CYP3A4 in human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310258200

The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310258200

Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310258200

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310258200

Pregnane X receptor (PXR), constitutive androstane receptor (CAR), and benzoate X receptor (BXR) define three pharmacologically distinct classes of nuclear receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310258200

Vitamin D receptor as an intestinal bile acid sensor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310258200

Disrupted bile acid homeostasis reveals an unexpected interaction among nuclear hormone receptors, transporters, and cytochrome P450.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310258200

Bile acid regulation of gene expression: roles of nuclear hormone receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310258200

Transgenic mouse models of human CYP3A4 gene regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310258200

Identification of CYP3A4 as the major enzyme responsible for 25-hydroxylation of 5beta-cholestane-3alpha,7alpha,12alpha-triol in human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310258200

Side chain hydroxylations in bile acid biosynthesis catalyzed by CYP3A are markedly up-regulated in Cyp27-/- mice but not in cerebrotendinous xanthomatosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310258200

Bile acid metabolism and the pathophysiology of cholestasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310258200

Bile acid synthesis and biliary hydrophobicity during obstructive jaundice in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310258200

Metabolism and effects on cholestasis of isoursodeoxycholic and ursodeoxycholic acids in bile duct ligated rats

21 January 2018

1 reference

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Protective role of hydroxysteroid sulfotransferase in lithocholic acid-induced liver toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310258200

Regulation of cholesterol and bile acid homoeostasis in bile-obstructed rats

21 January 2018

1 reference

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Bile acids: natural ligands for an orphan nuclear receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310258200

Regulation of a xenobiotic sulfonation cascade by nuclear pregnane X receptor (PXR).

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310258200

The small heterodimer partner interacts with the pregnane X receptor and represses its transcriptional activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310258200

The normal liver harbors the vitamin D nuclear receptor in nonparenchymal and biliary epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310258200

Nuclear pregnane x receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxification

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310258200

Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310258200

21 January 2018

Identifiers

DOI

10.1074/JBC.M310258200

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5 December 2017

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