(Q44705445)

5 December 2017

Tp53 deletion in B lineage cells predisposes mice to lymphomas with oncogenic translocations (English)

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5 December 2017

M A W Rowh

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5 December 2017

A DeMicco

2

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5 December 2017

J E Horowitz

3

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5 December 2017

B Yin

4

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5 December 2017

K S Yang-Iott

5

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5 December 2017

A M Fusello

6

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5 December 2017

E Hobeika

7

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5 December 2017

M Reth

8

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5 December 2017

C H Bassing

9

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5 December 2017

language of work or name

English

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publication date

30 May 2011

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5 December 2017

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5 December 2017

30

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5 December 2017

47

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5 December 2017

4757-4764

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https://scigraph.springernature.com/pub.10.1038/onc.2011.191

5 December 2017

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cites work

The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.191

Aberrant V(D)J recombination is not required for rapid development of H2ax/p53-deficient thymic lymphomas with clonal translocations.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.191

Histone H2AX: a dosage-dependent suppressor of oncogenic translocations and tumors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.191

H2AX haploinsufficiency modifies genomic stability and tumor susceptibility

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.191

Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.191

The significance of TP53 in lymphoid malignancies: mutation prevalence, regulation, prognostic impact and potential as a therapeutic target

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.191

Evidence for replicative repair of DNA double-strand breaks leading to oncogenic translocation and gene amplification

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.191

DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.191

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.191

ATM and p53 are essential in the cell-cycle containment of DNA breaks during V(D)J recombination in vivo.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.191

Genetic instability and mammary tumor formation in mice carrying mammary-specific disruption of Chk1 and p53.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.191

Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.191

A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.191

Leaky severe combined immunodeficiency and aberrant DNA rearrangements due to a hypomorphic RAG1 mutation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.191

The RAG-1/2 endonuclease causes genomic instability and controls CNS complications of lymphoblastic leukemia in p53/Prkdc-deficient mice.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.191

Block of T cell development in P53-deficient mice accelerates development of lymphomas with characteristic RAG-dependent cytogenetic alterations

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.191

Testing gene function early in the B cell lineage in mb1-cre mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.191

Tumor spectrum analysis in p53-mutant mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.191

Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.191

Mechanisms of B-cell lymphoma pathogenesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.191

No requirement for V(D)J recombination in p53-deficient thymic lymphoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.191

Growth inhibition and DNA damage induced by Cre recombinase in mammalian cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.191

Defective apoptosis and B-cell lymphomas in mice with p53 point mutation at Ser 23.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.191

AID and RAG1 do not contribute to lymphomagenesis in Emu c-myc transgenic mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.191

Role of genomic instability and p53 in AID-induced c-myc-Igh translocations.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.191

p53-deficient cells rely on ATM- and ATR-mediated checkpoint signaling through the p38MAPK/MK2 pathway for survival after DNA damage

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.191

AID produces DNA double-strand breaks in non-Ig genes and mature B cell lymphomas with reciprocal chromosome translocations

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.191

Artemis and p53 cooperate to suppress oncogenic N-myc amplification in progenitor B cells.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.191

Class switching and meiotic defects in mice lacking the E3 ubiquitin ligase RNF8

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.191

Self-excising retroviral vectors encoding the Cre recombinase overcome Cre-mediated cellular toxicity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.191

p53-mediated apoptosis prevents the accumulation of progenitor B cells and B-cell tumors.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.191

T-cell lymphomas mask slower developing B-lymphoid and myeloid tumours in transgenic mice with broad haemopoietic expression of MYC

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.191

Blinded by the Light: The Growing Complexity of p53

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.191

Oncogenic transformation in the absence of Xrcc4 targets peripheral B cells that have undergone editing and switching

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.191

Mechanisms promoting translocations in editing and switching peripheral B cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.191

Dramatically increased rearrangement and peripheral representation of Vbeta14 driven by the 3'Dbeta1 recombination signal sequence.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.191

Cellular context-dependent effects of H2ax and p53 deletion on the development of thymic lymphoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.191

Unrepaired DNA breaks in p53-deficient cells lead to oncogenic gene amplification subsequent to translocations.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.191

31 March 2020

Identifiers

DOI

10.1038/ONC.2011.191

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5 December 2017

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