(Q44789917)

6 December 2017

title

Development of an assay to screen for inhibitors of tau phosphorylation by cdk5. (English)

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6 December 2017

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2

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6 December 2017

7

Kenneth S Kosik

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6 December 2017

1

Jae Suk Ahn

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6 December 2017

Marina Mapelli

3

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6 December 2017

Jake Ni

4

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6 December 2017

Leonard Scinto

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6 December 2017

Ross Stein

6

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6 December 2017

Li-An Yeh

8

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6 December 2017

publication date

1 March 2004

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Journal of Biomolecular Screening

6 December 2017

published in

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6 December 2017

volume

9

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6 December 2017

issue

2

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6 December 2017

page(s)

122-131

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REVIEW: tau protein pathology in Alzheimer's disease and related disorders

6 December 2017

cites work

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https://api.crossref.org/works/10.1177%2F1087057103260594

Tau phosphorylation by cyclin-dependent kinase 5/p39 during brain development reduces its affinity for microtubules.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057103260594

Biopsy-derived adult human brain tau is phosphorylated at many of the same sites as Alzheimer's disease paired helical filament tau.

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057103260594

Distribution of the phosphorylated microtubule-associated protein tau in developing cortical neurons.

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057103260594

Differential distribution of tau proteins in developing cat cerebellum

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057103260594

Proline-directed and non-proline-directed phosphorylation of PHF-tau.

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057103260594

Specific tau phosphorylation sites correlate with severity of neuronal cytopathology in Alzheimer's disease.

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057103260594

Ca2+- and calmodulin-dependent phosphorylation of microtubule-associated protein 2 and tau factor, and inhibition of microtubule assembly.

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057103260594

Multisite phosphorylation of tau proteins from rat brain.

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057103260594

Phosphorylation that detaches tau protein from microtubules (Ser262, Ser214) also protects it against aggregation into Alzheimer paired helical filaments

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057103260594

Glycogen synthase kinase-3 and the Alzheimer-like state of microtubule-associated protein tau.

21 January 2018

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21 January 2018

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Alzheimer's disease. The tangled tale of tau.

21 January 2018

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Tau protein kinase II is involved in the regulation of the normal phosphorylation state of tau protein.

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057103260594

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057103260594

Tau domains, phosphorylation, and interactions with microtubules.

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057103260594

The endogenous and cell cycle-dependent phosphorylation of tau protein in living cells: implications for Alzheimer's disease

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057103260594

Tau phosphorylation at serine 396 and serine 404 by human recombinant tau protein kinase II inhibits tau's ability to promote microtubule assembly

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057103260594

A preparation of Alzheimer paired helical filaments that displays distinct tau proteins by polyacrylamide gel electrophoresis

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057103260594

Monoclonal antibody PHF-1 recognizes tau protein phosphorylated at serine residues 396 and 404.

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057103260594

Pharmacological inhibitors of cyclin-dependent kinases

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057103260594

CDK inhibition and cancer therapy

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057103260594

Properties and potential-applications of chemical inhibitors of cyclin-dependent kinases

21 January 2018

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Paullones are potent inhibitors of glycogen synthase kinase-3beta and cyclin-dependent kinase 5/p25.

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057103260594

Aloisines, a new family of CDK/GSK-3 inhibitors. SAR study, crystal structure in complex with CDK2, enzyme selectivity, and cellular effects

21 January 2018

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The microtubule binding domain of tau protein.

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057103260594

Structure and regulation of the CDK5-p25(nck5a) complex

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057103260594

Truncation of CDK5 activator p35 induces intensive phosphorylation of Ser202/Thr205 of human tau.

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057103260594

Inhibition of cyclin-dependent kinases by purine analogues.

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057103260594

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057103260594

Inhibition of cyclin-dependent kinases, GSK-3beta and CK1 by hymenialdisine, a marine sponge constituent

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057103260594

21 January 2018

Identifiers

DOI

10.1177/1087057103260594

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6 December 2017

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