(Q44833066)

6 December 2017

Inflammatory components in human Alzheimer's disease and after active amyloid-β42 immunization (English)

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6 December 2017

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10

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6 December 2017

Clive Holmes

5

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author name string

Elina Zotova

1

1 reference

6 December 2017

Viraj Bharambe

2

1 reference

6 December 2017

Matthew Cheaveau

3

1 reference

6 December 2017

William Morgan

4

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6 December 2017

Scott Harris

6

1 reference

6 December 2017

James W Neal

7

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6 December 2017

Seth Love

8

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6 December 2017

James A R Nicoll

9

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6 December 2017

language of work or name

English

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publication date

13 August 2013

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6 December 2017

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6 December 2017

136

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6 December 2017

Pt 9

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6 December 2017

2677-2696

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Actin-binding proteins coronin-1a and IBA-1 are effective microglial markers for immunohistochemistry

6 December 2017

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWT210

Inflammation and Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWT210

Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWT210

Reduction of aggregated Tau in neuronal processes but not in the cell bodies after Abeta42 immunisation in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWT210

Review: activation patterns of microglia and their identification in the human brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWT210

Consequence of Abeta immunization on the vasculature of human Alzheimer's disease brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWT210

Dynamics of the microglial/amyloid interaction indicate a role in plaque maintenance

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWT210

Effects of incorporation of immunoglobulin G and complement component C1q on uptake and degradation of Alzheimer's disease amyloid fibrils by microglia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWT210

In-vivo measurement of activated microglia in dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWT210

APOE epsilon 4 influences the pathological phenotype of Alzheimer's disease by favouring cerebrovascular over parenchymal accumulation of A beta protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWT210

Evidence that immunoglobulin-positive neurons in Alzheimer's disease are dying via the classical antibody-dependent complement pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWT210

Clearance of amyloid-beta peptide across the blood-brain barrier: implication for therapies in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWT210

IgG-assisted age-dependent clearance of Alzheimer's amyloid beta peptide by the blood-brain barrier neonatal Fc receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWT210

Microglia, amyloid, and cognition in Alzheimer's disease: An [11C](R)PK11195-PET and [11C]PIB-PET study

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWT210

Amyloid, hypometabolism, and cognition in Alzheimer disease: an [11C]PIB and [18F]FDG PET study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWT210

The role of complement and activated microglia in the pathogenesis of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWT210

Scavenger receptor-mediated adhesion of microglia to beta-amyloid fibrils

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWT210

Neuropathology and pathogenesis of encephalitis following amyloid-beta immunization in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWT210

Absence of C1q leads to less neuropathology in transgenic mouse models of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWT210

Clinical effects of Abeta immunization (AN1792) in patients with AD in an interrupted trial.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWT210

Alzheimer's disease: paired helical filaments and cytomembranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWT210

Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWT210

TREM2 Variants in Alzheimer's Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWT210

Alzheimer's disease: the amyloid cascade hypothesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWT210

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWT210

Diverse microglial responses after intrahippocampal administration of lipopolysaccharide

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWT210

Microglial activation is required for Abeta clearance after intracranial injection of lipopolysaccharide in APP transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWT210

Antibodies against beta-amyloid slow cognitive decline in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWT210

Long-term effects of Abeta42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWT210

Immunohistochemical evidence for a macrophage scavenger receptor in Mato cells and reactive microglia of ischemia and Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWT210

Scavenger receptors in neurobiology and neuropathology: their role on microglia and other cells of the nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWT210

Autoantibodies to amyloid-beta and Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWT210

A novel gene iba1 in the major histocompatibility complex class III region encoding an EF hand protein expressed in a monocytic lineage

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWT210

Intracellular signaling in M-CSF-induced microglia activation: role of Iba1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWT210

Microglial activation parallels system degeneration in progressive supranuclear palsy and corticobasal degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWT210

A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWT210

Amyloid precursor protein processing and A beta42 deposition in a transgenic mouse model of Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWT210

Variant of TREM2 Associated with the Risk of Alzheimer's Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWT210

Macrophage/microglia-specific protein Iba1 enhances membrane ruffling and Rac activation via phospholipase C-gamma -dependent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWT210

Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWT210

Modeling Alzheimer's disease immune therapy mechanisms: interactions of human postmortem microglia with antibody-opsonized amyloid beta peptide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWT210

The biochemical aftermath of anti-amyloid immunotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWT210

Minocycline reduces engraftment and activation of bone marrow-derived cells but sustains their phagocytic activity in a mouse model of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWT210

Microglia in cerebellar plaques in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWT210

Reactive microglia in patients with senile dementia of the Alzheimer type are positive for the histocompatibility glycoprotein HLA-DR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWT210

Immunotherapy for Alzheimer's disease: rational basis in ongoing clinical trials.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWT210

A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWT210

Abeta species removal after abeta42 immunization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWT210

Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: a case report.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWT210

Fcgamma receptors: old friends and new family members

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWT210

Subacute meningoencephalitis in a subset of patients with AD after Abeta42 immunization

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWT210

Reactive microglia in aging and dementia: an immunohistochemical study of postmortem human brain tissue.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWT210

Slow degradation of aggregates of the Alzheimer's disease amyloid beta-protein by microglial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWT210

Microglial cells internalize aggregates of the Alzheimer's disease amyloid beta-protein via a scavenger receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWT210

Identification of Fc gamma RI, II and III on normal human brain ramified microglia and on microglia in senile plaques in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWT210

Microglia in neurodegenerative disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWT210

Macrosialin, a macrophage-restricted membrane sialoprotein differentially glycosylated in response to inflammatory stimuli

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWT210

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWT210

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWT210

Microglial cells around amyloid plaques in Alzheimer's disease express leucocyte adhesion molecules of the LFA-1 family

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWT210

Neural progenitor cells attenuate inflammatory reactivity and neuronal loss in an animal model of inflamed AD brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWT210

Iba1 is an actin-cross-linking protein in macrophages/microglia

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWT210

Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWT210

Reactive glia not only associates with plaques but also parallels tangles in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWT210

Complement activation by neurofibrillary tangles in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWT210

Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWT210

The Alzheimer's disease-associated amyloid beta-protein is an antimicrobial peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWT210

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWT210

Dystrophic (senescent) rather than activated microglial cells are associated with tau pathology and likely precede neurodegeneration in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWT210

Reactive microglia in multiple sclerosis lesions have an increased expression of receptors for the Fc part of IgG.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWT210

Antibody-mediated phagocytosis of the amyloid beta-peptide in microglia is differentially modulated by C1q.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWT210

Number of Abeta inoculations in APP+PS1 transgenic mice influences antibody titers, microglial activation, and congophilic plaque levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWT210

Microglial activation facilitates Abeta plaque removal following intracranial anti-Abeta antibody administration

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWT210

Passive amyloid immunotherapy clears amyloid and transiently activates microglia in a transgenic mouse model of amyloid deposition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWT210

Diverse inflammatory responses in transgenic mouse models of Alzheimer's disease and the effect of immunotherapy on these responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWT210

Microglial alterations in human Alzheimer's disease following Aβ42 immunization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWT210

Inflammation in Alzheimer's disease: relevance to pathogenesis and therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWT210

Evaluation of the safety and immunogenicity of synthetic A 42 (AN1792) in patients with AD

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWT210

21 January 2018

Identifiers

DOI

10.1093/BRAIN/AWT210

1 reference

6 December 2017

1 reference