(Q44844612)

6 December 2017

Probing the druggability of protein-protein interactions: targeting the Notch1 receptor ankyrin domain using a fragment-based approach (English)

1 reference

protein-protein interaction

6 December 2017

1 reference

3

Tom L Blundell

1 reference

6 December 2017

Noha Abdel-Rahman

1

1 reference

PubMed ID

21936810

6 December 2017

Alfonso Martinez-Arias

series ordinal

2

1 reference

6 December 2017

1 October 2011

1 reference

Biochemical Society Transactions

6 December 2017

1 reference

6 December 2017

39

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6 December 2017

5

1 reference

6 December 2017

1327-1333

1 reference

Reaching for high-hanging fruit in drug discovery at protein-protein interfaces

6 December 2017

1 reference

https://api.crossref.org/works/10.1042%2FBST0391327

Direct inhibition of the NOTCH transcription factor complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0391327

Protein-protein interactions in receptor activation and intracellular signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0391327

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0391327

Structural biology and bioinformatics in drug design: opportunities and challenges for target identification and lead discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0391327

Structure-based maximal affinity model predicts small-molecule druggability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0391327

A hot spot of binding energy in a hormone-receptor interface

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0391327

Anatomy of hot spots in protein interfaces

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0391327

Strategies for targeting protein-protein interactions with synthetic agents.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0391327

Protein surface recognition and proteomimetics: mimics of protein surface structure and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0391327

Discovering high-affinity ligands for proteins: SAR by NMR

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0391327

High-throughput crystallography for lead discovery in drug design.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0391327

Structural biology in fragment-based drug design

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0391327

Notch signaling: cell fate control and signal integration in development

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0391327

21 January 2018

Notch signaling pathway

1 reference

https://api.crossref.org/works/10.1042%2FBST0391327

TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0391327

Specific truncations of Drosophila Notch define dominant activated and dominant negative forms of the receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0391327

The molecular logic of Notch signaling--a structural and biochemical perspective.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0391327

Intrinsic activity of the Lin-12 and Notch intracellular domains in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0391327

Presenilin is required for activity and nuclear access of Notch in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0391327

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0391327

The suppressor of hairless protein participates in notch receptor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0391327

MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0391327

Notch signaling, gamma-secretase inhibitors, and cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0391327

Therapeutic antibody targeting of individual Notch receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0391327

Characterization of Notch1 antibodies that inhibit signaling of both normal and mutated Notch1 receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0391327

A ‘Rule of Three’ for fragment-based lead discovery?

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0391327

Evaluation of fluorescence-based thermal shift assays for hit identification in drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0391327

Druggability indices for protein targets derived from NMR-based screening data

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0391327

Privileged molecules for protein binding identified from NMR-based screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0391327

Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0391327

Mutational and energetic studies of Notch 1 transcription complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0391327

High-resolution crystal structure of the human Notch 1 ankyrin domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0391327

Structure and stability of the ankyrin domain of the Drosophila Notch receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0391327

Cooperative assembly of higher-order Notch complexes functions as a switch to induce transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0391327

Structural and mechanistic insights into cooperative assembly of dimeric Notch transcription complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0391327

21 January 2018

Identifiers

DOI

10.1042/BST0391327

1 reference

6 December 2017

1 reference

PubMed ID

21936810