(Q44881265)

7 December 2017

title

Dissecting the cell-killing mechanism of the topoisomerase II-targeting drug ICRF-193. (English)

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7 December 2017

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7 December 2017

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Anni H Andersen

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7 December 2017

Birgitta R Knudsen

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7 December 2017

language of work or name

English

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publication date

28 April 2004

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Journal of Biological Chemistry

7 December 2017

published in

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7 December 2017

volume

279

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7 December 2017

issue

27

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7 December 2017

page(s)

28100-28105

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DNA topoisomerase II is required at the time of mitosis in yeast

7 December 2017

cites work

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https://api.crossref.org/works/10.1074%2FJBC.M402119200

Analysis of functional domain organization in DNA topoisomerase II from humans and Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402119200

DNA transport by a type II topoisomerase: direct evidence for a two-gate mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402119200

Structure of the topoisomerase II ATPase region and its mechanism of inhibition by the chemotherapeutic agent ICRF-187

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402119200

Topoisomerase II as a target for anticancer drugs: when enzymes stop being nice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402119200

Antitumor bisdioxopiperazines inhibit yeast DNA topoisomerase II by trapping the enzyme in the form of a closed protein clamp

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402119200

Inhibition of DNA topoisomerase II by ICRF-193 induces polyploidization by uncoupling chromosome dynamics from other cell cycle events

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402119200

Decreased topoisomerase IIalpha expression confers increased resistance to ICRF-193 as well as VP-16 in mouse embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402119200

Hypersensitivity of nonhomologous DNA end-joining mutants to VP-16 and ICRF-193: implications for the repair of topoisomerase II-mediated DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402119200

Characterization of a Chinese hamster ovary cell line with acquired resistance to the bisdioxopiperazine dexrazoxane (ICRF-187) catalytic inhibitor of topoisomerase II.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402119200

Differential expression of topoisomerase I and RAD52 protein in yeast reveals new facets of the mechanism of action of bisdioxopiperazine compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402119200

DNA strand breaks induced by the anti-topoisomerase II bis-dioxopiperazine ICRF-193.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M402119200

Topoisomerase II poisoning by ICRF-193.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M402119200

Hypersensitivity of Ku-deficient cells toward the DNA topoisomerase II inhibitor ICRF-193 suggests a novel role for Ku antigen during the G2 and M phases of the cell cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402119200

Hindering the strand passage reaction of human topoisomerase IIalpha without disturbing DNA cleavage, ATP hydrolysis, or the operation of the N-terminal clamp

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402119200

The transducer domain is important for clamp operation in human DNA topoisomerase IIalpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402119200

DNA topoisomerase-targeting antitumor drugs can be studied in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402119200

Kinetic and thermodynamic analysis of mutant type II DNA topoisomerases that cannot covalently cleave DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402119200

The topoisomerase IIbeta circular clamp arrests transcription and signals a 26S proteasome pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402119200

21 January 2018

Identifiers

DOI

10.1074/JBC.M402119200

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7 December 2017

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