(Q44937777)

7 December 2017

title

Familial hypercholesterolemia and atherosclerosis in cloned minipigs created by DNA transposition of a human PCSK9 gain-of-function mutant (English)

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familial hypercholesterolemia

7 December 2017

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18

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7 December 2017

Jacob Giehm Mikkelsen

20

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Charlotte Brandt Sørensen

7 December 2017

Rozh H Al-Mashhadi

1

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Charlotte B Sørensen

2

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Martin Bødtker Mortensen

Martin B Mortensen

5

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Christina Christoffersen

Christina Christoffersen

4

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Lars P Tolbod

Lars P Tolbod

6

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Jacob Fog Bentzon

Jacob F Bentzon

21

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Lars Bolund

16

Lars Bolund

1 reference

7 December 2017

Peter M Kragh

3

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7 December 2017

Troels Thim

7

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7 December 2017

Yutao Du

8

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7 December 2017

Juan Li

9

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7 December 2017

Ying Liu

10

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7 December 2017

Brian Moldt

11

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7 December 2017

Mette Schmidt

12

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7 December 2017

Gabor Vajta

13

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7 December 2017

Torben Larsen

14

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7 December 2017

Stig Purup

15

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7 December 2017

Lars B Nielsen

17

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7 December 2017

Erling Falk

19

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7 December 2017

language of work or name

English

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publication date

1 January 2013

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Science Translational Medicine

7 December 2017

published in

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7 December 2017

volume

5

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7 December 2017

issue

166

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7 December 2017

page(s)

166ra1

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Progress and challenges in translating the biology of atherosclerosis

7 December 2017

cites work

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004853

Evidence mandating earlier and more aggressive treatment of hypercholesterolemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004853

Atherosclerosis drug development in jeopardy: the need for predictive biomarkers of treatment response

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004853

Safety and efficacy of dalcetrapib on atherosclerotic disease using novel non-invasive multimodality imaging (dal-PLAQUE): a randomised clinical trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004853

Simvastatin attenuates plaque inflammation: evaluation by fluorodeoxyglucose positron emission tomography.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004853

(18)Fluorodeoxyglucose positron emission tomography imaging of atherosclerotic plaque inflammation is highly reproducible: implications for atherosclerosis therapy trials.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004853

A prospective natural-history study of coronary atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004853

Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004853

Atherosclerotic lesions in mouse and man: is it the same disease?

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004853

Pigs in sequence space: a 0.66X coverage pig genome survey based on shotgun sequencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004853

Swine as models in biomedical research and toxicology testing

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004853

Drug-eluting stents in preclinical studies: updated consensus recommendations for preclinical evaluation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004853

Intracoronary optical coherence tomography and histology at 1 month and 2, 3, and 4 years after implantation of everolimus-eluting bioresorbable vascular scaffolds in a porcine coronary artery model: an attempt to decipher the human optical coherenc

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004853

The unique role of proprotein convertase subtilisin/kexin 9 in cholesterol homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004853

Binding of proprotein convertase subtilisin/kexin type 9 to epidermal growth factor-like repeat A of low density lipoprotein receptor decreases receptor recycling and increases degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004853

Molecular basis for LDL receptor recognition by PCSK9

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004853

Unexpected roles for PCSK9 in lipid metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004853

Pig genome sequence--analysis and publication strategy

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004853

Inclusion of the hepatic locus control region, an intron, and untranslated region increases and stabilizes hepatic factor IX gene expression in vivo but not in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004853

Hemizygous minipigs produced by random gene insertion and handmade cloning express the Alzheimer's disease-causing dominant mutation APPsw

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004853

Lessons from sudden coronary death: a comprehensive morphological classification scheme for atherosclerotic lesions

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004853

Increased secretion of lipoproteins in transgenic mice expressing human D374Y PCSK9 under physiological genetic control.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004853

Pig transgenesis by Sleeping Beauty DNA transposition

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004853

Genetic and metabolic determinants of plasma PCSK9 levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004853

Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and in livers of parabiotic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004853

Inhibition of lipoprotein-associated phospholipase A2 reduces complex coronary atherosclerotic plaque development

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004853

Targeting bile-acid signalling for metabolic diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004853

ApoE-deficient mice on cholate-containing high-fat diet reveal a pathology similar to lung sarcoidosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004853

Diet and murine atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004853

Simvastatin preserves diastolic function in experimental hypercholesterolemia independently of its lipid lowering effect

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004853

Nonhomologous-End-Joining Factors Regulate DNA Repair Fidelity during Sleeping Beauty Element Transposition in Mammalian Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004853

Mutational analysis of the N-terminal DNA-binding domain of sleeping beauty transposase: critical residues for DNA binding and hyperactivity in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004853

Somatic integration and long-term transgene expression in normal and haemophilic mice using a DNA transposon system

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004853

Molecular evolution of a novel hyperactive Sleeping Beauty transposase enables robust stable gene transfer in vertebrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004853

Production of endothelial nitric oxide synthase (eNOS) over-expressing piglets.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004853

Preferential influx and decreased fractional loss of lipoprotein(a) in atherosclerotic compared with nonlesioned rabbit aorta

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004853

Effect of apolipoprotein M on high density lipoprotein metabolism and atherosclerosis in low density lipoprotein receptor knock-out mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004853

Imaging atherosclerotic plaque inflammation with [18F]-fluorodeoxyglucose positron emission tomography.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004853

Atherosclerosis inflammation imaging with 18F-FDG PET: carotid, iliac, and femoral uptake reproducibility, quantification methods, and recommendations

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004853

10.1126/SCITRANSLMED.3004853

21 January 2018

Identifiers

DOI

1 reference

7 December 2017

1 reference