(Q44958687)

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Mass spectrometry-based quantification of CYP enzymes to establish in vitro/in vivo scaling factors for intestinal and hepatic metabolism in beagle dog.

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Europe PubMed Central

PubMed publication ID

7 December 2017

Mass spectrometry-based quantification of CYP enzymes to establish in vitro/in vivo scaling factors for intestinal and hepatic metabolism in beagle dog. (English)

1 reference

Europe PubMed Central

PubMed publication ID

7 December 2017

Aki T. Heikkinen

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Aki T Heikkinen

1

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2

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Arno Friedlein

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author name string

Arno Friedlein

2

1 reference

Europe PubMed Central

PubMed publication ID

7 December 2017

Jens Lamerz

3

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Europe PubMed Central

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7 December 2017

Peter Jakob

4

1 reference

Europe PubMed Central

PubMed publication ID

7 December 2017

Paul Cutler

5

1 reference

Europe PubMed Central

PubMed publication ID

7 December 2017

Stephen Fowler

6

1 reference

Europe PubMed Central

PubMed publication ID

7 December 2017

Tara Williamson

7

1 reference

Europe PubMed Central

PubMed publication ID

7 December 2017

Roberto Tolando

8

1 reference

Europe PubMed Central

PubMed publication ID

7 December 2017

Thierry Lave

9

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Europe PubMed Central

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7 December 2017

Neil Parrott

10

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Europe PubMed Central

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7 December 2017

publication date

22 February 2012

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7 December 2017

Pharmaceutical Research

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Europe PubMed Central

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7 December 2017

29

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Europe PubMed Central

PubMed publication ID

7 December 2017

7

1 reference

Europe PubMed Central

PubMed publication ID

7 December 2017

1832-1842

1 reference

Europe PubMed Central

PubMed publication ID

7 December 2017

Predicting pharmacokinetic food effects using biorelevant solubility media and physiologically based modelling.

1 reference

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Predicting pharmacokinetics of drugs using physiologically based modeling--application to food effects

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Cytochrome P450-mediated metabolism in the human gut wall

1 reference

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Grapefruit juice-drug interaction studies as a method to assess the extent of intestinal availability: utility and limitations.

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Evaluation of Escherichia coli membrane preparations of canine CYP1A1, 2B11, 2C21, 2C41, 2D15, 3A12, and 3A26 with coexpressed canine cytochrome P450 reductase

1 reference

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Scaling factors for the extrapolation of in vivo metabolic drug clearance from in vitro data: reaching a consensus on values of human microsomal protein and hepatocellularity per gram of liver.

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Substrate specificity and kinetic properties of seven heterologously expressed dog cytochromes p450.

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Multi-site assessment of the precision and reproducibility of multiple reaction monitoring-based measurements of proteins in plasma

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Selected reaction monitoring for quantitative proteomics: a tutorial

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Variance component analysis of a multi-site study for the reproducibility of multiple reaction monitoring measurements of peptides in human plasma

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Simulation of human intravenous and oral pharmacokinetics of 21 diverse compounds using physiologically based pharmacokinetic modelling

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Characterization of cytochrome P450 (CYP3A12) induction by rifampicin in dog liver

1 reference

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21 January 2018

Induction of intestinal cytochrome P450 (CYP3A) by rifampicin in beagle dogs

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0707-7

21 January 2018

Determination of microsome and hepatocyte scaling factors for in vitro/in vivo extrapolation in the rat and dog.

1 reference

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21 January 2018

Covariation of human microsomal protein per gram of liver with age: absence of influence of operator and sample storage may justify interlaboratory data pooling

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0707-7

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Development of a highly sensitive method using liquid chromatography-multiple reaction monitoring to quantify membrane P-glycoprotein in biological matrices and relationship to transport function

1 reference

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Simultaneous absolute quantification of 11 cytochrome P450 isoforms in human liver microsomes by liquid chromatography tandem mass spectrometry with in silico target peptide selection.

1 reference

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21 January 2018

A new cytochrome P450 form belonging to the CYP2D in dog liver microsomes: purification, cDNA cloning, and enzyme characterization

1 reference

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21 January 2018

Characterization of cytochrome P450 protein expression along the entire length of the intestine of male and female rats

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0707-7

21 January 2018

Disparity in holoprotein/apoprotein ratios of different standards used for immunoquantification of hepatic cytochrome P450 enzymes

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0707-7

21 January 2018

Prediction of human intestinal first-pass metabolism of 25 CYP3A substrates from in vitro clearance and permeability data.

1 reference

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21 January 2018

In vivo pharmacokinetics of felodipine predicted from in vitro studies in rat, dog and man

1 reference

https://pubmed.ncbi.nlm.nih.gov/22354837

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Determination of a human hepatic microsomal scaling factor for predicting in vivo drug clearance

1 reference

https://pubmed.ncbi.nlm.nih.gov/22354837

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of human small intestinal cytochromes P-450.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22354837

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. I. EVIDENCE FOR ITS HEMOPROTEIN NATURE

1 reference

https://pubmed.ncbi.nlm.nih.gov/22354837

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rat small intestinal cytochromes P450 probed by warfarin metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/22354837

12 December 2020

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Cytochrome P450 Pig liver pie: determination of individual cytochrome P450 isoform contents in microsomes from two pig livers using liquid chromatography in conjunction with mass spectrometry [corrected]

1 reference

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12 December 2020

based on heuristic

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Intestinal and Hepatic Metabolic Activity of Five Cytochrome P450 Enzymes: Impact on Prediction of First-Pass Metabolism

1 reference

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12 December 2020

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Isolation of a new canine cytochrome P450 CDNA from the cytochrome P450 2C subfamily (CYP2C41) and evidence for polymorphic differences in its expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/22354837

12 December 2020

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Quantitative atlas of membrane transporter proteins: development and application of a highly sensitive simultaneous LC/MS/MS method combined with novel in-silico peptide selection criteria

1 reference

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inferred from PubMed ID database lookup

A novel strategy for physiologically based predictions of human pharmacokinetics

1 reference

https://pubmed.ncbi.nlm.nih.gov/22354837

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based on heuristic

inferred from PubMed ID database lookup

Characterization of interintestinal and intraintestinal variations in human CYP3A-dependent metabolism.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22354837

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based on heuristic

inferred from PubMed ID database lookup

The barrier function of CYP3A4 and P-glycoprotein in the small bowel

1 reference

https://pubmed.ncbi.nlm.nih.gov/22354837

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytochrome P450 3A expression and activity in the human small intestine

1 reference

https://pubmed.ncbi.nlm.nih.gov/22354837

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Blood-brain barrier (BBB) pharmacoproteomics: reconstruction of in vivo brain distribution of 11 P-glycoprotein substrates based on the BBB transporter protein concentration, in vitro intrinsic transport activity, and unbound fraction in plasma and

1 reference

https://pubmed.ncbi.nlm.nih.gov/22354837

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S11095-012-0707-7

1 reference

Europe PubMed Central

PubMed publication ID

7 December 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

7 December 2017

ResearchGate publication ID

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