(Q45046738)

8 December 2017

title

Simulation of human intravenous and oral pharmacokinetics of 21 diverse compounds using physiologically based pharmacokinetic modelling (English)

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8 December 2017

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Hannah M Jones

1

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8 December 2017

Iain B Gardner

2

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8 December 2017

Wendy T Collard

3

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8 December 2017

Phil J Stanley

4

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8 December 2017

Penny Oxley

5

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8 December 2017

Natilie A Hosea

6

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8 December 2017

David Plowchalk

7

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8 December 2017

Steve Gernhardt

8

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8 December 2017

Jing Lin

9

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8 December 2017

Maurice Dickins

10

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8 December 2017

S Ravi Rahavendran

11

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8 December 2017

Barry C Jones

12

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8 December 2017

Kenny J Watson

13

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8 December 2017

Henry Pertinez

14

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8 December 2017

Vikas Kumar

15

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8 December 2017

Susan Cole

16

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8 December 2017

language of work or name

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1 May 2011

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Clinical Pharmacokinetics

8 December 2017

published in

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8 December 2017

volume

50

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8 December 2017

issue

5

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8 December 2017

page(s)

331-347

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https://scigraph.springernature.com/pub.10.2165/11539680-000000000-00000

8 December 2017

exact match

0 references

1 reference

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Interspecies scaling, allometry, physiological time, and the ground plan of pharmacokinetics.

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Physiologically based pharmacokinetics in drug development and regulatory science: a workshop report (Georgetown University, Washington, DC, May 29-30, 2002).

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Whole body pharmacokinetic models

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Development of physiologically based pharmacokinetic and physiologically based pharmacodynamic models for applications in toxicology and risk assessment.

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Utility of in vitro drug metabolism data in predicting in vivo metabolic clearance

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Prediction of in vivo drug clearance from in vitro data. I: impact of inter-individual variability

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A priori prediction of tissue:plasma partition coefficients of drugs to facilitate the use of physiologically-based pharmacokinetic models in drug discovery.

21 January 2018

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Prediction of pharmacokinetics prior to in vivo studies. 1. Mechanism-based prediction of volume of distribution.

21 January 2018

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Prediction of adipose tissue: plasma partition coefficients for structurally unrelated drugs

21 January 2018

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Volume of distribution at steady state for a linear pharmacokinetic system with peripheral elimination

21 January 2018

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Physiologically based pharmacokinetic modeling 1: predicting the tissue distribution of moderate-to-strong bases.

21 January 2018

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Physiologically based pharmacokinetic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions.

21 January 2018

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Mechanistic approaches to volume of distribution predictions: understanding the processes.

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Predicting the impact of physiological and biochemical processes on oral drug bioavailability

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A physiological model for the estimation of the fraction dose absorbed in humans.

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Prediction of pharmacokinetics prior to in vivo studies. II. Generic physiologically based pharmacokinetic models of drug disposition

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Utility of physiologically based pharmacokinetic models to drug development and rational drug discovery candidate selection.

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Prediction of human pharmacokinetics using physiologically based modeling: a retrospective analysis of 26 clinically tested drugs.

21 January 2018

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Evaluation of a generic physiologically based pharmacokinetic model for lineshape analysis

21 January 2018

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Integrating in vitro ADMET data through generic physiologically based pharmacokinetic models

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The Simcyp population-based ADME simulator

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Physiological parameter values for physiologically based pharmacokinetic models

21 January 2018

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A compartmental absorption and transit model for estimating oral drug absorption.

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Prediction of human drug clearance from in vitro and preclinical data using physiologically based and empirical approaches

21 January 2018

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Prediction of the pharmacokinetics of atorvastatin, cerivastatin, and indomethacin using kinetic models applied to isolated rat hepatocytes

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Evaluation of cryopreserved human hepatocytes as an alternative in vitro system to microsomes for the prediction of metabolic clearance.

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Evaluation of fresh and cryopreserved hepatocytes as in vitro drug metabolism tools for the prediction of metabolic clearance

21 January 2018

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An evaluation of the utility of physiologically based models of pharmacokinetics in early drug discovery.

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Predicting pharmacokinetic food effects using biorelevant solubility media and physiologically based modelling.

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Evaluation of a basic physiologically based pharmacokinetic model for simulating the first-time-in-animal study.

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The prediction of drug metabolism, tissue distribution, and bioavailability of 50 structurally diverse compounds in rat using mechanism-based absorption, distribution, and metabolism prediction tools.

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Whole body physiologically-based pharmacokinetic models: their use in clinical drug development

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Prediction of human clearance of twenty-nine drugs from hepatic microsomal intrinsic clearance data: An examination of in vitro half-life approach and nonspecific binding to microsomes.

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Prediction of human pharmacokinetics from preclinical information: comparative accuracy of quantitative prediction approaches

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Challenges and opportunities with modelling and simulation in drug discovery and drug development

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Physiologically based pharmacokinetic study on a cyclosporin derivative, SDZ IMM 125

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A novel strategy for physiologically based predictions of human pharmacokinetics

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12 December 2020

10.2165/11539680-000000000-00000

Identifiers

DOI

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Dimensions Publication ID

8 December 2017

1002029445

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