(Q45025723)

English

Gabapentin-lactam, but not gabapentin, reduces protein aggregates and improves motor performance in a transgenic mouse model of Huntington's disease

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

8 December 2017

Gabapentin-lactam, but not gabapentin, reduces protein aggregates and improves motor performance in a transgenic mouse model of Huntington's disease (English)

1 reference

Europe PubMed Central

PubMed publication ID

8 December 2017

Huntington's disease

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Bernhard Landwehrmeyer

5

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Europe PubMed Central

PubMed publication ID

8 December 2017

author name string

Birgit Zucker

1

1 reference

Europe PubMed Central

PubMed publication ID

8 December 2017

Dagmar E Ludin

2

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Europe PubMed Central

PubMed publication ID

8 December 2017

Thomas A Gerds

3

1 reference

Europe PubMed Central

PubMed publication ID

8 December 2017

Carl H Lücking

4

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Europe PubMed Central

PubMed publication ID

8 December 2017

Thomas J Feuerstein

6

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Europe PubMed Central

PubMed publication ID

8 December 2017

publication date

30 July 2004

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Europe PubMed Central

PubMed publication ID

8 December 2017

Naunyn-Schmiedeberg's Archives of Pharmacology

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Europe PubMed Central

PubMed publication ID

8 December 2017

370

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Europe PubMed Central

PubMed publication ID

8 December 2017

2

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Europe PubMed Central

PubMed publication ID

8 December 2017

131-139

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Europe PubMed Central

PubMed publication ID

8 December 2017

Tiagabine synergistically interacts with gabapentin in the electroconvulsive threshold test in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/15322735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Early mitochondrial calcium defects in Huntington's disease are a direct effect of polyglutamines.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15322735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Decreased expression of striatal signaling genes in a mouse model of Huntington's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/15322735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aggregated polyglutamine peptides delivered to nuclei are toxic to mammalian cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/15322735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genotypes at the GluR6 kainate receptor locus are associated with variation in the age of onset of Huntington disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/15322735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/15322735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative stress, glutamate, and neurodegenerative disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/15322735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biochemical abnormalities and excitotoxicity in Huntington's disease brain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15322735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abnormal association of mutant huntingtin with synaptic vesicles inhibits glutamate release

1 reference

https://pubmed.ncbi.nlm.nih.gov/15322735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cellular localization and development of neuronal intranuclear inclusions in striatal and cortical neurons in R6/2 transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/15322735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impaired glutamate uptake in the R6 Huntington's disease transgenic mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15322735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gabapentin-lactam, a close analogue of the anticonvulsant gabapentin, exerts convulsant activity in amygdala kindled rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/15322735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pivotal role of oligomerization in expanded polyglutamine neurodegenerative disorders.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15322735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of polyglutamine aggregation in R6/2 HD brain slices-complex dose-response profiles

1 reference

https://pubmed.ncbi.nlm.nih.gov/15322735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Huntingtin-encoded polyglutamine expansions form amyloid-like protein aggregates in vitro and in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/15322735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impaired glutamate transport and glutamate-glutamine cycling: downstream effects of the Huntington mutation

1 reference

https://pubmed.ncbi.nlm.nih.gov/15322735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/15322735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A polymorphic DNA marker genetically linked to Huntington's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/15322735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15322735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Altered brain neurotransmitter receptors in transgenic mice expressing a portion of an abnormal human huntington disease gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/15322735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantitative autoradiography of neurotransmitter receptors in Huntington disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/15322735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The clinical pharmacokinetics of the new antiepileptic drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/15322735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Placebo-controlled trial of gabapentin in patients with amyotrophic lateral sclerosis. WALS Study Group. Western Amyotrophic Lateral Sclerosis Study Group

1 reference

https://pubmed.ncbi.nlm.nih.gov/15322735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The neuroprotective properties of gabapentin-lactam

1 reference

https://pubmed.ncbi.nlm.nih.gov/15322735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase III randomized trial of gabapentin in patients with amyotrophic lateral sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/15322735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Specific progressive cAMP reduction implicates energy deficit in presymptomatic Huntington's disease knock-in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/15322735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutamine repeats as polar zippers: their possible role in inherited neurodegenerative diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/15322735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15322735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Huntington disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/15322735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proteases acting on mutant huntingtin generate cleaved products that differentially build up cytoplasmic and nuclear inclusions

1 reference

https://pubmed.ncbi.nlm.nih.gov/15322735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective discrimination learning impairments in mice expressing the human Huntington's disease mutation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15322735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anticonvulsants for neuropathic pain syndromes: mechanisms of action and place in therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/15322735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Excitatory amino acids as a final common pathway for neurologic disorders.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15322735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Benefit of vitamin E, riluzole, and gabapentin in a transgenic model of familial amyotrophic lateral sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/15322735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Accumulation of mutant huntingtin fragments in aggresome-like inclusion bodies as a result of insufficient protein degradation

1 reference

https://pubmed.ncbi.nlm.nih.gov/15322735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Huntingtin aggregation and toxicity in Huntington's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/15322735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nuclear and neuropil aggregates in Huntington's disease: relationship to neuropathology.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15322735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Determination of gabapentin-lactam in serum of patients under gabapentin therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/15322735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of huntingtin fibrillogenesis by specific antibodies and small molecules: implications for Huntington's disease therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/15322735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Therapeutic effects of cystamine in a murine model of Huntington's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15322735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutation of the E6-AP ubiquitin ligase reduces nuclear inclusion frequency while accelerating polyglutamine-induced pathology in SCA1 mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15322735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation

1 reference

https://pubmed.ncbi.nlm.nih.gov/15322735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Disposition of gabapentin (neurontin) in mice, rats, dogs, and monkeys

1 reference

https://pubmed.ncbi.nlm.nih.gov/15322735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Retinal ganglion cell survival is enhanced by gabapentin-lactam in vitro: evidence for involvement of mitochondrial KATP channels

1 reference

https://pubmed.ncbi.nlm.nih.gov/15322735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gabapentin-lactam (8-aza-spiro[5,4]decan-9-on; GBP-L) inhibits oxygen glucose deprivation-induced [3H]glutmate release and is a neuroprotective agent in amodel of acute retinal ischemia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15322735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

1 reference

https://pubmed.ncbi.nlm.nih.gov/15322735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Is Pharmacological Neuroprotection Dependent on Reduced Glutamate Release?

1 reference

https://pubmed.ncbi.nlm.nih.gov/15322735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Self-assembly of polyglutamine-containing huntingtin fragments into amyloid-like fibrils: implications for Huntington's disease pathology

1 reference

https://pubmed.ncbi.nlm.nih.gov/15322735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of progressive motor deficits in mice transgenic for the human Huntington's disease mutation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15322735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00210-004-0959-9

1 reference

Europe PubMed Central

PubMed publication ID

8 December 2017

Dimensions Publication ID

0 references

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

8 December 2017

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