(Q45052873)

9 December 2017

The constitutive androstane receptor and pregnane X receptor function coordinately to prevent bile acid-induced hepatotoxicity (English)

1 reference

9 December 2017

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Ronald M Evans

4

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author name string

Jun Zhang

1

1 reference

9 December 2017

Wendong Huang

2

1 reference

9 December 2017

Mohammed Qatanani

3

1 reference

9 December 2017

David D Moore

5

1 reference

9 December 2017

language of work or name

English

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publication date

8 September 2004

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Journal of Biological Chemistry

9 December 2017

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9 December 2017

279

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9 December 2017

47

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9 December 2017

49517-49522

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An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids.

9 December 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409041200

PXR, CAR and drug metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409041200

Drug-activated nuclear receptors CAR and PXR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409041200

A nuclear receptor-mediated xenobiotic response and its implication in drug metabolism and host protection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409041200

Humanized xenobiotic response in mice expressing nuclear receptor SXR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409041200

The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409041200

Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CAR

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409041200

Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409041200

Specific and overlapping functions of the nuclear hormone receptors CAR and PXR in xenobiotic response

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409041200

Nuclear pregnane x receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxification

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409041200

Induction of bilirubin clearance by the constitutive androstane receptor (CAR)

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409041200

Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409041200

Regulation of bile acid synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409041200

Bile acid metabolism and the pathophysiology of cholestasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409041200

6alpha-hydroxylation of taurochenodeoxycholic acid and lithocholic acid by CYP3A4 in human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409041200

Purification and characterization of bile salt sulfotransferase from human liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409041200

Bile acids: natural ligands for an orphan nuclear receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409041200

Identification of a nuclear receptor for bile acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409041200

Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409041200

Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409041200

Bile acid regulation of gene expression: roles of nuclear hormone receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409041200

Protective role of hydroxysteroid sulfotransferase in lithocholic acid-induced liver toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409041200

Regulation of a xenobiotic sulfonation cascade by nuclear pregnane X receptor (PXR).

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409041200

Complementary roles of farnesoid X receptor, pregnane X receptor, and constitutive androstane receptor in protection against bile acid toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409041200

A novel constitutive androstane receptor-mediated and CYP3A-independent pathway of bile acid detoxification

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409041200

Modulation of acetaminophen-induced hepatotoxicity by the xenobiotic receptor CAR

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409041200

Role of constitutive androstane receptor in the in vivo induction of Mrp3 and CYP2B1/2 by phenobarbital.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409041200

The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409041200

Pregnane X receptor (PXR), constitutive androstane receptor (CAR), and benzoate X receptor (BXR) define three pharmacologically distinct classes of nuclear receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409041200

Phenobarbital-responsive nuclear translocation of the receptor CAR in induction of the CYP2B gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409041200

The peptide near the C terminus regulates receptor CAR nuclear translocation induced by xenochemicals in mouse liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409041200

Vitamin D receptor as an intestinal bile acid sensor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409041200

Identification of membrane-type receptor for bile acids (M-BAR)

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409041200

A G protein-coupled receptor responsive to bile acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409041200

Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409041200

Deoxycholic acid activates the c-Jun N-terminal kinase pathway via FAS receptor activation in primary hepatocytes. Role of acidic sphingomyelinase-mediated ceramide generation in FAS receptor activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409041200

Treatment of itching associated with intrahepatic cholestasis of pregnancy

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409041200

21 January 2018

Identifiers

DOI

10.1074/JBC.M409041200

1 reference

9 December 2017

1 reference