(Q45067002)

9 December 2017

title

Integrated Population Pharmacokinetic Model of both cyclophosphamide and thiotepa suggesting a mutual drug-drug interaction (English)

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9 December 2017

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4

Jos H Beijnen

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9 December 2017

2

Alwin D R Huitema

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9 December 2017

3

Sjoerd Rodenhuis

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9 December 2017

Milly E de Jonge

1

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9 December 2017

publication date

1 April 2004

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Journal of Pharmacokinetics and Pharmacodynamics

9 December 2017

published in

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9 December 2017

volume

31

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9 December 2017

issue

2

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9 December 2017

page(s)

135-156

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Cellular pharmacology of N,N',N''-triethylene thiophosphoramide

9 December 2017

cites work

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12 December 2020

Pharmacokinetics of high dose thiotepa in children undergoing autologous bone marrow transplantation

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12 December 2020

Phase I/pharmacokinetic reevaluation of thioTEPA

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12 December 2020

High-dose chemotherapy regimens for solid tumors

1 reference

12 December 2020

A search for new metabolites of N,N',N''-triethylenethiophosphoramide

1 reference

12 December 2020

Nonlinear pharmacokinetics of cyclophosphamide in patients with metastatic breast cancer receiving high-dose chemotherapy followed by autologous bone marrow transplantation

1 reference

12 December 2020

Pharmacokinetics of cyclophosphamide and its metabolites in bone marrow transplantation patients

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12 December 2020

High-dose chemotherapy with hematopoietic stem-cell rescue for high-risk breast cancer.

1 reference

12 December 2020

Phase I trial of thiotepa in combination with recombinant human granulocyte-macrophage colony-stimulating factor

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12 December 2020

Induction of cytochrome P450 2B6 and 3A4 expression by phenobarbital and cyclophosphamide in cultured human liver slices.

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12 December 2020

Development of a substrate-activity based approach to identify the major human liver P-450 catalysts of cyclophosphamide and ifosfamide activation based on cDNA-expressed activities and liver microsomal P-450 profiles

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12 December 2020

Plasma concentrations of 4-hydroxycyclophosphamide and phosphoramide mustard in patients repeatedly given high doses of cyclophosphamide in preparation for bone marrow transplantation

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12 December 2020

Simultaneous determination of N,N',N"-triethylenethiophosphoramide, cyclophosphamide and some of their metabolites in plasma using capillary gas chromatography

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12 December 2020

High-dose i.v. thiotepa and cryopreserved autologous bone marrow transplantation for therapy of refractory cancer

1 reference

12 December 2020

Phase I and pharmacokinetic evaluation of thiotepa in the cerebrospinal fluid and plasma of pediatric patients: evidence for dose-dependent plasma clearance of thiotepa.

1 reference

12 December 2020

In vivo modulation of alternative pathways of P-450-catalyzed cyclophosphamide metabolism: impact on pharmacokinetics and antitumor activity

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12 December 2020

Human plasma pharmacokinetics and urinary excretion of thiotepa and its metabolites

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12 December 2020

Activation of thio-tepa cytotoxicity toward human breast-cancer cells by hepatic cytochrome-p450.

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12 December 2020

A mechanism-based pharmacokinetic model for the cytochrome P450 drug-drug interaction between cyclophosphamide and thioTEPA and the autoinduction of cyclophosphamide

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12 December 2020

Reduction of cyclophosphamide bioactivation by thioTEPA: critical sequence-dependency in high-dose chemotherapy regimens

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12 December 2020

Conventional-dose chemotherapy compared with high-dose chemotherapy plus autologous hematopoietic stem-cell transplantation for metastatic breast cancer. Philadelphia Bone Marrow Transplant Group

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12 December 2020

Rapid development of enhanced clearance after high-dose cyclophosphamide

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12 December 2020

Pharmacokinetics of thio-TEPA and TEPA in the conventional dose-range and its correlation to myelosuppressive effects

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12 December 2020

Triethylenethiophosphoramide is a specific inhibitor of cytochrome P450 2B6: implications for cyclophosphamide metabolism

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12 December 2020

A multi-center prospective phase II study of high-dose chemotherapy in germ-cell cancer patients relapsing from complete remission

1 reference

12 December 2020

Human CYP2B6: expression, inducibility and catalytic activities

1 reference

12 December 2020

Feasibility of multiple courses of high-dose cyclophosphamide, thiotepa, and carboplatin for breast cancer or germ cell cancer

1 reference

12 December 2020

Identification of the polymorphically expressed CYP2C19 and the wild-type CYP2C9-ILE359 allele as low-Km catalysts of cyclophosphamide and ifosfamide activation.

1 reference

12 December 2020

Cyclophosphamide and 4-Hydroxycyclophosphamide/aldophosphamide kinetics in patients receiving high-dose cyclophosphamide chemotherapy

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12 December 2020

A mechanism-based pharmacokinetic-enzyme model for cyclophosphamide autoinduction in breast cancer patients

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12 December 2020

Modulation of thiotepa antitumor activity in vivo by alteration of liver cytochrome P450-catalyzed drug metabolism.

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12 December 2020

Plasma pharmacokinetics and tissue distribution of thiotepa in mice.

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12 December 2020

Evidence for enzymatic activation and oxygen involvement in cytotoxicity and antitumor activity of N,N',N''-triethylenethiophosphoramide

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12 December 2020

N,N',N''-triethylenethiophosphoramide (thio-TEPA) oxygenation by constitutive hepatic P450 enzymes and modulation of drug metabolism and clearance in vivo by P450-inducing agents

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12 December 2020

Fractionated administration of high-dose cyclophosphamide: influence on dose-dependent changes in pharmacokinetics and metabolism

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12 December 2020

Biotransformation of N,N',N''-triethylenethiophosphoramide: oxidative desulfuration to yield N,N',N''-triethylenephosphoramide associated with suicide inactivation of a phenobarbital-inducible hepatic P-450 monooxygenase

1 reference

12 December 2020

Long-term pharmacokinetics of thio-TEPA, TEPA and total alkylating activity following i. v. bolus administration of thio-TEPA in ovarian cancer patients

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12 December 2020

Population pharmacokinetics of thioTEPA and its active metabolite TEPA in patients undergoing high-dose chemotherapy

1 reference

12 December 2020

Pharmacokinetics of continuous-infusion high-dose thiotepa

1 reference

12 December 2020

A phase I-II study of cyclophosphamide, thiotepa, and carboplatin with autologous bone marrow transplantation in solid tumor patients

1 reference

12 December 2020

Differential activation of cyclophosphamide and ifosphamide by cytochromes P-450 2B and 3A in human liver microsomes

1 reference

12 December 2020

Phase II study of a multi-course high-dose chemotherapy regimen incorporating cyclophosphamide, thiotepa, and carboplatin in stage IV breast cancer

1 reference

12 December 2020

Clinical pharmacokinetics of cyclophosphamide

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12 December 2020

Enhanced cyclophosphamide and ifosfamide activation in primary human hepatocyte cultures: response to cytochrome P-450 inducers and autoinduction by oxazaphosphorines

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12 December 2020

A phase II study of thioTEPA in children with recurrent solid tumor malignancies: a Children's Cancer Group study.

1 reference

12 December 2020

The effect of cyclophosphamide with and without dexamethasone on cytochrome P450 3A4 and 2B6 in human hepatocytes

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12 December 2020

Randomised trial of high-dose chemotherapy and haemopoietic progenitor-cell support in operable breast cancer with extensive axillary lymph-node involvement

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12 December 2020

Cytochrome P450 isozymes 3A4 and 2B6 are involved in the in vitro human metabolism of thiotepa to TEPA.

1 reference

12 December 2020

A phase I/II study of high-dose cyclophosphamide, cisplatin, and thioTEPA followed by autologous bone marrow and granulocyte colony-stimulating factor-primed peripheral-blood progenitor cells in patients with advanced malignancies

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12 December 2020

Single and repeated dose pharmacokinetics of thio-TEPA in patients treated for ovarian carcinoma

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12 December 2020

Pharmacokinetics of thio-TEPA at two different doses.

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12 December 2020

Oxidation of cyclophosphamide to 4-hydroxycyclophosphamide and deschloroethylcyclophosphamide in human liver microsomes

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12 December 2020

Metabolism and alkylating activity of thio-TEPA in rat liver slice incubation

1 reference

12 December 2020

10.1023/B:JOPA.0000034405.03895.C2

Identifiers

DOI

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Dimensions Publication ID

9 December 2017

1021260380

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Fatcat ID

release_vgszpkkerffjpbnxmm7wnv7t3e

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Fatcat

https://api.fatcat.wiki/v0/release/vgszpkkerffjpbnxmm7wnv7t3e

24 November 2022

mapped directly with Wikidata item

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