(Q45096788)

English

The E693Δ (Osaka) mutation in amyloid precursor protein potentiates cholesterol-mediated intracellular amyloid β toxicity via its impaired cholesterol efflux

scientific article published on 16 September 2013

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scholarly article

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Europe PubMed Central

9 December 2017

The E693Δ (Osaka) mutation in amyloid precursor protein potentiates cholesterol-mediated intracellular amyloid β toxicity via its impaired cholesterol efflux (English)

1 reference

Europe PubMed Central

9 December 2017

Ōsaka mutation

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author name string

Sachiko Nomura

1

1 reference

Europe PubMed Central

9 December 2017

Tomohiro Umeda

2

1 reference

Europe PubMed Central

9 December 2017

Takami Tomiyama

3

1 reference

Europe PubMed Central

9 December 2017

Hiroshi Mori

4

1 reference

Europe PubMed Central

9 December 2017

language of work or name

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publication date

16 September 2013

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Europe PubMed Central

9 December 2017

Journal of Neuroscience Research

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Europe PubMed Central

9 December 2017

91

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Europe PubMed Central

9 December 2017

12

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Europe PubMed Central

9 December 2017

1541-1550

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Europe PubMed Central

9 December 2017

Cholesterol modulates alpha-secretase cleavage of amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1002%2FJNR.23278

21 January 2018

Cholesterol sensing, trafficking, and esterification.

1 reference

https://api.crossref.org/works/10.1002%2FJNR.23278

21 January 2018

Mitochondrial cholesterol loading exacerbates amyloid beta peptide-induced inflammation and neurotoxicity

1 reference

https://api.crossref.org/works/10.1002%2FJNR.23278

21 January 2018

The role of cholesterol in the biosynthesis of beta-amyloid

1 reference

https://api.crossref.org/works/10.1002%2FJNR.23278

21 January 2018

Astrocytic expression of the Alzheimer's disease beta-secretase (BACE1) is stimulus-dependent

1 reference

https://api.crossref.org/works/10.1002%2FJNR.23278

21 January 2018

Interferon gamma stimulates beta-secretase expression and sAPPbeta production in astrocytes

1 reference

https://api.crossref.org/works/10.1002%2FJNR.23278

21 January 2018

Mitochondria are a direct site of A beta accumulation in Alzheimer's disease neurons: implications for free radical generation and oxidative damage in disease progression

1 reference

https://api.crossref.org/works/10.1002%2FJNR.23278

21 January 2018

The E693Delta mutation in amyloid precursor protein increases intracellular accumulation of amyloid beta oligomers and causes endoplasmic reticulum stress-induced apoptosis in cultured cells

1 reference

https://api.crossref.org/works/10.1002%2FJNR.23278

21 January 2018

Cholesterol metabolism in neurons and astrocytes.

1 reference

https://api.crossref.org/works/10.1002%2FJNR.23278

21 January 2018

Non-vesicular sterol transport in cells

1 reference

https://api.crossref.org/works/10.1002%2FJNR.23278

21 January 2018

Neuronal and glial beta-secretase (BACE) protein expression in transgenic Tg2576 mice with amyloid plaque pathology

1 reference

https://api.crossref.org/works/10.1002%2FJNR.23278

21 January 2018

Cholesterol-modifying strategies for Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1002%2FJNR.23278

21 January 2018

Cholesterol in Alzheimer's disease: unresolved questions.

1 reference

https://api.crossref.org/works/10.1002%2FJNR.23278

21 January 2018

NPC1/NPC2 function as a tag team duo to mobilize cholesterol

1 reference

https://api.crossref.org/works/10.1002%2FJNR.23278

21 January 2018

Syntaxin 5 interacts with presenilin holoproteins, but not with their N- or C-terminal fragments, and affects beta-amyloid peptide production

1 reference

https://api.crossref.org/works/10.1002%2FJNR.23278

21 January 2018

Synaptic activity reduces intraneuronal Abeta, promotes APP transport to synapses, and protects against Abeta-related synaptic alterations

1 reference

https://api.crossref.org/works/10.1002%2FJNR.23278

21 January 2018

A new amyloid beta variant favoring oligomerization in Alzheimer's-type dementia.

1 reference

https://api.crossref.org/works/10.1002%2FJNR.23278

21 January 2018

A mouse model of amyloid beta oligomers: their contribution to synaptic alteration, abnormal tau phosphorylation, glial activation, and neuronal loss in vivo.

1 reference

https://api.crossref.org/works/10.1002%2FJNR.23278

21 January 2018

Intraneuronal amyloid β oligomers cause cell death via endoplasmic reticulum stress, endosomal/lysosomal leakage, and mitochondrial dysfunction in vivo.

1 reference

https://api.crossref.org/works/10.1002%2FJNR.23278

21 January 2018

Hypercholesterolemia accelerates intraneuronal accumulation of Aβ oligomers resulting in memory impairment in Alzheimer's disease model mice.

1 reference

https://api.crossref.org/works/10.1002%2FJNR.23278

21 January 2018

Cholesterol retention in Alzheimer's brain is responsible for high beta- and gamma-secretase activities and Abeta production

1 reference

https://api.crossref.org/works/10.1002%2FJNR.23278

21 January 2018

Assembly of high-density lipoprotein

1 reference

https://api.crossref.org/works/10.1002%2FJNR.23278

21 January 2018

Beta-secretase processing of the beta-amyloid precursor protein in transgenic mice is efficient in neurons but inefficient in astrocytes

1 reference

https://api.crossref.org/works/10.1002%2FJNR.23278

21 January 2018

Identifiers

10.1002/JNR.23278

1 reference

Europe PubMed Central

9 December 2017

1 reference

Europe PubMed Central

9 December 2017

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