(Q37150804)

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The E693Delta mutation in amyloid precursor protein increases intracellular accumulation of amyloid beta oligomers and causes endoplasmic reticulum stress-induced apoptosis in cultured cells

scientific article published on 22 January 2009

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20 January 2020

The E693Delta mutation in amyloid precursor protein increases intracellular accumulation of amyloid beta oligomers and causes endoplasmic reticulum stress-induced apoptosis in cultured cells (English)

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20 January 2020

apoptotic process

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endoplasmic reticulum

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inferred from title

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20 January 2020

William L. Klein

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William L Klein

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20 January 2020

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Kazuchika Nishitsuji

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20 January 2020

Takami Tomiyama

2

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20 January 2020

Kenichi Ishibashi

3

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20 January 2020

Rie Teraoka

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20 January 2020

Mary P Lambert

6

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20 January 2020

Hiroshi Mori

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20 January 2020

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22 January 2009

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20 January 2020

The American Journal of Pathology

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20 January 2020

174

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20 January 2020

3

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20 January 2020

957-969

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20 January 2020

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Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

1 reference

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Inverse correlation between amyloid precursor protein and synaptic plasticity in transgenic mice

1 reference

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6 September 2017

Intracellular amyloid-beta in Alzheimer's disease

1 reference

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6 September 2017

Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway

1 reference

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6 September 2017

A Oligomer-Induced Aberrations in Synapse Composition, Shape, and Density Provide a Molecular Basis for Loss of Connectivity in Alzheimer's Disease

1 reference

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6 September 2017

Intracellular Abeta and cognitive deficits precede beta-amyloid deposition in transgenic arcAbeta mice

1 reference

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6 September 2017

Alzheimer's disease beta-amyloid peptides are released in association with exosomes

1 reference

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6 September 2017

A specific amyloid-beta protein assembly in the brain impairs memory

1 reference

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6 September 2017

Amyloidogenic processing of beta-amyloid precursor protein in intracellular compartments

1 reference

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6 September 2017

ER stress and neurodegenerative diseases

1 reference

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6 September 2017

Macroautophagy--a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease

1 reference

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6 September 2017

Intraneuronal Abeta accumulation and origin of plaques in Alzheimer's disease

1 reference

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6 September 2017

Calcium dysregulation and membrane disruption as a ubiquitous neurotoxic mechanism of soluble amyloid oligomers

1 reference

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6 September 2017

Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function

1 reference

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6 September 2017

Synaptic targeting by Alzheimer's-related amyloid beta oligomers.

1 reference

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6 September 2017

A modified beta-amyloid hypothesis: intraneuronal accumulation of the beta-amyloid peptide--the first step of a fatal cascade

1 reference

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6 September 2017

Massive CA1/2 neuronal loss with intraneuronal and N-terminal truncated Abeta42 accumulation in a novel Alzheimer transgenic model

1 reference

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6 September 2017

Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and Abeta-induced cell death

1 reference

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6 September 2017

Syntaxin 5 interacts with presenilin holoproteins, but not with their N- or C-terminal fragments, and affects beta-amyloid peptide production

1 reference

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6 September 2017

Regulation of apoptosis by endoplasmic reticulum pathways.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2665755

6 September 2017

Alzheimer's disease-affected brain: presence of oligomeric A beta ligands (ADDLs) suggests a molecular basis for reversible memory loss

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2665755

6 September 2017

Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction

1 reference

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6 September 2017

Intraneuronal Alzheimer abeta42 accumulates in multivesicular bodies and is associated with synaptic pathology

1 reference

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6 September 2017

Alzheimer's disease is a synaptic failure

1 reference

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6 September 2017

Reversible memory loss in a mouse transgenic model of Alzheimer's disease

1 reference

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6 September 2017

Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

1 reference

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6 September 2017

Targeting small Abeta oligomers: the solution to an Alzheimer's disease conundrum?

1 reference

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6 September 2017

Evidence that neurones accumulating amyloid can undergo lysis to form amyloid plaques in Alzheimer's disease

1 reference

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6 September 2017

Lysosomal membrane damage in soluble Abeta-mediated cell death in Alzheimer's disease

1 reference

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6 September 2017

The endosomal-lysosomal system of neurons in Alzheimer's disease pathogenesis: a review

1 reference

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6 September 2017

High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation

1 reference

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6 September 2017

Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta

1 reference

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6 September 2017

Intraneuronal Abeta42 accumulation in human brain.

1 reference

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6 September 2017

Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease

1 reference

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6 September 2017

Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls

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Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

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Distinct sites of intracellular production for Alzheimer's disease A beta40/42 amyloid peptides.

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Generation of Alzheimer beta-amyloid protein in the trans-Golgi network in the apparent absence of vesicle formation

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1 reference

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Reactivity of apolipoprotein E4 and amyloid beta peptide: lysosomal stability and neurodegeneration

1 reference

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14 September 2017

Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation.

1 reference

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27 June 2018

Loss of endosomal/lysosomal membrane impermeability is an early event in amyloid Abeta1-42 pathogenesis

1 reference

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Alzheimer's A beta(1-42) is generated in the endoplasmic reticulum/intermediate compartment of NT2N cells

1 reference

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Water-soluble Abeta (N-40, N-42) oligomers in normal and Alzheimer disease brains

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A new amyloid beta variant favoring oligomerization in Alzheimer's-type dementia.

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3 September 2018

Monoclonal antibodies that target pathological assemblies of Abeta

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3 September 2018

Absence of synaptophysin near cortical neurons containing oligomer Abeta in Alzheimer's disease brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2665755

3 September 2018

The Arctic Alzheimer mutation facilitates early intraneuronal Abeta aggregation and senile plaque formation in transgenic mice

1 reference

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Temporal profile of amyloid-beta (Abeta) oligomerization in an in vivo model of Alzheimer disease. A link between Abeta and tau pathology

1 reference

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3 September 2018

Intraneuronal Abeta causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice

1 reference

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1 reference

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3 September 2018

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3 September 2018

Intraneuronal abeta-amyloid precedes development of amyloid plaques in Down syndrome

1 reference

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Deposition of beta-amyloid subtypes 40 and 42 differentiates dementia with Lewy bodies from Alzheimer disease

1 reference

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3 September 2018

Identifiers

10.2353/AJPATH.2009.080480

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19164507%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19164507%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19164507%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

ResearchGate publication ID

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