(Q40143145)

English

The Arctic Alzheimer mutation favors intracellular amyloid-beta production by making amyloid precursor protein less available to alpha-secretase

scientific article published on May 2007

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scholarly article

1 reference

Europe PubMed Central

17 September 2017

The Arctic Alzheimer mutation favors intracellular amyloid-beta production by making amyloid precursor protein less available to alpha-secretase (English)

1 reference

Europe PubMed Central

17 September 2017

Alzheimer's disease

0 references

6

1 reference

Europe PubMed Central

17 September 2017

Gunnar K. Gouras

8

1 reference

Europe PubMed Central

17 September 2017

Cláudia Guimas Almeida

object named as

Claudia G Almeida

5

0 references

Hillevi Englund

4

object named as

Hillevi Englund

1 reference

Europe PubMed Central

17 September 2017

9

object named as

Lars Lannfelt

1 reference

Europe PubMed Central

17 September 2017

author name string

Charlotte Sahlin

1

1 reference

Europe PubMed Central

17 September 2017

Anna Lord

2

1 reference

Europe PubMed Central

17 September 2017

Kristina Magnusson

3

1 reference

Europe PubMed Central

17 September 2017

Fred Nyberg

7

1 reference

Europe PubMed Central

17 September 2017

Lars N G Nilsson

10

1 reference

Europe PubMed Central

17 September 2017

language of work or name

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publication date

1 May 2007

1 reference

Europe PubMed Central

17 September 2017

Journal of Neurochemistry

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Europe PubMed Central

17 September 2017

101

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Europe PubMed Central

17 September 2017

3

1 reference

Europe PubMed Central

17 September 2017

854-862

1 reference

Europe PubMed Central

17 September 2017

A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04443.X

21 January 2018

A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid

1 reference

5 June 2022

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Amyloid beta protein precursor gene and hereditary cerebral hemorrhage with amyloidosis (Dutch)

1 reference

12 October 2022

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Expression of human beta-secretase in the mouse brain increases the steady-state level of beta-amyloid.

1 reference

12 October 2022

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Presenile dementia and cerebral haemorrhage linked to a mutation at codon 692 of the beta-amyloid precursor protein gene.

1 reference

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An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants.

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Statin treatment and a disease-specific pattern of beta-amyloid peptides in Alzheimer's disease

1 reference

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The alpha-helical to beta-strand transition in the amino-terminal fragment of the amyloid beta-peptide modulates amyloid formation

1 reference

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Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production

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Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex

1 reference

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Physiochemical characterization of the Alzheimer's disease-related peptides A beta 1-42Arctic and A beta 1-42wt.

1 reference

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Amyloid-beta oligomers are inefficiently measured by enzyme-linked immunosorbent assay

1 reference

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Cleavage of Alzheimer's amyloid precursor protein by alpha-secretase occurs at the surface of neuronal cells

1 reference

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Reconstitution of gamma-secretase activity

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Alzheimer's disease: genes, proteins, and therapy

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Translating cell biology into therapeutic advances in Alzheimer's disease

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Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

1 reference

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Cell-type and amyloid precursor protein-type specific inhibition of A beta release by bafilomycin A1, a selective inhibitor of vacuolar ATPases

1 reference

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ADAMs family members as amyloid precursor protein alpha-secretases

1 reference

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Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type.

1 reference

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Beta-amyloid precursor protein cleavage by a membrane-bound protease

1 reference

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The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease

1 reference

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Amyloid beta-protein fibrillogenesis. Detection of a protofibrillar intermediate.

1 reference

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Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease

1 reference

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The Arctic Alzheimer mutation facilitates early intraneuronal Abeta aggregation and senile plaque formation in transgenic mice.

1 reference

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Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor

1 reference

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"Secretase," Alzheimer amyloid protein precursor secreting enzyme is not sequence-specific

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Amyloid, the presenilins and Alzheimer's disease

1 reference

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Early-onset and robust cerebral microvascular accumulation of amyloid beta-protein in transgenic mice expressing low levels of a vasculotropic Dutch/Iowa mutant form of amyloid beta-protein precursor

1 reference

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Protein kinase C-dependent alpha-secretase competes with beta-secretase for cleavage of amyloid-beta precursor protein in the trans-golgi network

1 reference

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Enhanced pathologic properties of Dutch-type mutant amyloid beta-protein

1 reference

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Abeta is targeted to the vasculature in a mouse model of hereditary cerebral hemorrhage with amyloidosis.

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Decreased α-secretase-cleaved amyloid precursor protein as a diagnostic marker for Alzheimer's diseas

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Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

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The C-terminus of the beta protein is critical in amyloidogenesis

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Synthesis, aggregation, neurotoxicity, and secondary structure of various A beta 1-42 mutants of familial Alzheimer's disease at positions 21-23.

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Aggressive amyloidosis in mice expressing human amyloid peptides with the Arctic mutation

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The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway

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Intracellular APP processing and A beta production in Alzheimer disease

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Relative abundance of Alzheimer A beta amyloid peptide variants in Alzheimer disease and normal aging

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Novel amyloid precursor protein mutation in an Iowa family with dementia and severe cerebral amyloid angiopathy

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Alzheimer's disease: the amyloid cascade hypothesis

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Amyloid precursor protein processing and A beta42 deposition in a transgenic mouse model of Alzheimer disease

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The Arctic mutation interferes with processing of the amyloid precursor protein

1 reference

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The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Abeta protofibril formation

1 reference

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Observation of metastable Abeta amyloid protofibrils by atomic force microscopy

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Identifiers

10.1111/J.1471-4159.2006.04443.X

1 reference

Europe PubMed Central

17 September 2017

1 reference

Europe PubMed Central

17 September 2017

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