(Q45115027)

9 December 2017

title

Hyperphosphorylation and aggregation of tau in experimental autoimmune encephalomyelitis (English)

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experimental autoimmune encephalomyelitis

9 December 2017

main subject

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author

Robert Weissert

7

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9 December 2017

8

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9 December 2017

6

Eva-Maria Mandelkow

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9 December 2017

Anja Schneider

1

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9 December 2017

Gilda Wright Araújo

2

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9 December 2017

Katarina Trajkovic

3

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9 December 2017

Martin M Herrmann

4

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9 December 2017

Doron Merkler

5

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9 December 2017

language of work or name

English

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publication date

19 October 2004

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Journal of Biological Chemistry

9 December 2017

published in

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9 December 2017

volume

279

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9 December 2017

issue

53

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9 December 2017

page(s)

55833-55839

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https://api.crossref.org/works/10.1074%2FJBC.M409954200

9 December 2017

1 reference

Multiple sclerosis: deeper understanding of its pathogenesis reveals new targets for therapy.

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Axonal and neuronal degeneration in multiple sclerosis: mechanisms and functional consequences

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Axonal pathology in multiple sclerosis. A historical note

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Axonal damage in acute multiple sclerosis lesions.

21 January 2018

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Axonal transection in the lesions of multiple sclerosis

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M409954200

Acute axonal damage in multiple sclerosis is most extensive in early disease stages and decreases over time

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M409954200

Multiple sclerosis and chronic autoimmune encephalomyelitis: a comparative quantitative study of axonal injury in active, inactive, and remyelinated lesions

21 January 2018

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Molecular mechanisms of axonal damage in inflammatory central nervous system diseases

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M409954200

Neurodegenerative tauopathies

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409954200

Overexpression of tau protein inhibits kinesin-dependent trafficking of vesicles, mitochondria, and endoplasmic reticulum: implications for Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409954200

Structure of tau protein and assembly into paired helical filaments

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409954200

Purification of paired helical filament tau and normal tau from human brain tissue

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M409954200

MHC haplotype-dependent regulation of MOG-induced EAE in rats.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M409954200

Detection of Phosphorylated Ser262 in Fetal Tau, Adult Tau, and Paired Helical Filament Tau

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409954200

Phosphorylation of Ser262 strongly reduces binding of tau to microtubules: distinction between PHF-like immunoreactivity and microtubule binding.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409954200

Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409954200

Cdk5 is a key factor in tau aggregation and tangle formation in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409954200

Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409954200

Hyperphosphorylated tau and neurofilament and cytoskeletal disruptions in mice overexpressing human p25, an activator of cdk5

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409954200

Reduced protein phosphatase 2A activity induces hyperphosphorylation and altered compartmentalization of tau in transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409954200

Specific tau phosphorylation sites correlate with severity of neuronal cytopathology in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409954200

The endogenous and cell cycle-dependent phosphorylation of tau protein in living cells: implications for Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409954200

A preparation of Alzheimer paired helical filaments that displays distinct tau proteins by polyacrylamide gel electrophoresis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409954200

Disruption of Cnp1 uncouples oligodendroglial functions in axonal support and myelination

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409954200

Activation of mitogen-activated protein kinases in experimental autoimmune encephalomyelitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409954200

Interaction of neuronal Cdc2-like protein kinase with microtubule-associated protein tau.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409954200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409954200

Coexpression of human cdk5 and its activator p35 with human protein tau in neurons in brain of triple transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409954200

Truncation of CDK5 activator p35 induces intensive phosphorylation of Ser202/Thr205 of human tau.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409954200

Direct impact of T cells on neurons revealed by two-photon microscopy in living brain tissue.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409954200

Neuropathological stageing of Alzheimer-related changes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409954200

Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409954200

Toward a unified scheme for the aggregation of tau into Alzheimer paired helical filaments

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409954200

PAR-1 kinase plays an initiator role in a temporally ordered phosphorylation process that confers tau toxicity in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409954200

Folding proteins in fatal ways

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409954200

Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409954200

Tauopathy in Drosophila: neurodegeneration without neurofibrillary tangles

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409954200

Tau protein isoforms, phosphorylation and role in neurodegenerative disorders11These authors contributed equally to this work

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409954200

21 January 2018

Identifiers

DOI

10.1074/JBC.M409954200

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9 December 2017

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