(Q45211779)

10 December 2017

title

Modulated nucleoside kinases as tools to improve the activation of therapeutic nucleoside analogues (English)

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10 December 2017

Christian Monnerjahn

1

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10 December 2017

Manfred Konrad

series ordinal

2

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10 December 2017

publication date

1 March 2003

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10 December 2017

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10 December 2017

volume

4

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10 December 2017

issue

2-3

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10 December 2017

page(s)

143-146

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Nucleoside analogues and nucleobases in cancer treatment.

10 December 2017

cites work

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200390024

cycloSal-pronucleotides design of chemical trojan horses

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200390024

Differential ganciclovir-mediated cell killing by glutamine 125 mutants of herpes simplex virus type 1 thymidine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200390024

Prodrug activation enzymes in cancer gene therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200390024

Conservative mutations of glutamine-125 in herpes simplex virus type 1 thymidine kinase result in a ganciclovir kinase with minimal deoxypyrimidine kinase activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200390024

Crystal structures of the thymidine kinase from herpes simplex virus type-1 in complex with deoxythymidine and ganciclovir

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200390024

The structures of thymidine kinase from herpes simplex virus type 1 in complex with substrates and a substrate analogue

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200390024

Exploring the active site of herpes simplex virus type-1 thymidine kinase by X-ray crystallography of complexes with aciclovir and other ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200390024

Drug resistance of herpes simplex virus type 1--structural considerations at the molecular level of the thymidine kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200390024

The A167Y mutation converts the herpes simplex virus type 1 thymidine kinase into a guanosine analogue kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200390024

The equine herpes virus 4 thymidine kinase is a better suicide gene than the human herpes virus 1 thymidine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200390024

Phosphorylation of 3'-azido-3'-deoxythymidine and selective interaction of the 5'-triphosphate with human immunodeficiency virus reverse transcriptase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200390024

Cytotoxicity of 3'-azido-3'-deoxythymidine correlates with 3'-azidothymidine-5'-monophosphate (AZTMP) levels, whereas anti-human immunodeficiency virus (HIV) activity correlates with 3'-azidothymidine-5'-triphosphate (AZTTP) levels in cultured CEM T

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200390024

Crystal structure of yeast thymidylate kinase complexed with the bisubstrate inhibitor P1-(5'-adenosyl) P5-(5'-thymidyl) pentaphosphate (TP5A) at 2.0 A resolution: implications for catalysis and AZT activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200390024

Structure of thymidylate kinase reveals the cause behind the limiting step in AZT activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200390024

Structural basis for efficient phosphorylation of 3'-azidothymidine monophosphate by Escherichia coli thymidylate kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200390024

Insights into the phosphoryltransfer mechanism of human thymidylate kinase gained from crystal structures of enzyme complexes along the reaction coordinate

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200390024

Potentiating AZT activation: structures of wild-type and mutant human thymidylate kinase suggest reasons for the mutants' improved kinetics with the HIV prodrug metabolite AZTMP

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200390024

Current progress in suicide gene therapy for cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200390024

Gene therapy: trials and tribulations

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200390024

Protein transduction technology

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200390024

The bottleneck in AZT activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200390024

Modifying Human Thymidylate Kinase to Potentiate Azidothymidine Activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200390024

Realism in drug discovery-could Cassandra be right?

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200390024

21 January 2018

Identifiers

DOI

10.1002/CBIC.200390024

1 reference

10 December 2017

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