(Q45279418)

11 December 2017

title

Dual role of orphan nuclear receptor pregnane X receptor in bilirubin detoxification in mice (English)

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11 December 2017

Simrat P S Saini

1

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11 December 2017

Ying Mu

2

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11 December 2017

Haibiao Gong

3

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11 December 2017

David Toma

4

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11 December 2017

Hirdesh Uppal

5

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11 December 2017

Songrong Ren

6

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11 December 2017

Song Li

7

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11 December 2017

Samuel M Poloyac

8

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11 December 2017

Wen Xie

9

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11 December 2017

language of work or name

English

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publication date

1 March 2005

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11 December 2017

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11 December 2017

volume

41

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11 December 2017

issue

3

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11 December 2017

page(s)

497-505

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A new orphan member of the nuclear hormone receptor superfamily that interacts with a subset of retinoic acid response elements

11 December 2017

cites work

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The nuclear orphan receptor CAR-retinoid X receptor heterodimer activates the phenobarbital-responsive enhancer module of the CYP2B gene

21 January 2018

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The Biology of Bilirubin Production

21 January 2018

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7 January 2021

Mechanism of indinavir-induced hyperbilirubinemia

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7 January 2021

Hepatic uptake of bilirubin and its conjugates by the human organic anion transporter SLC21A6

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7 January 2021

The genetic basis of the reduced expression of bilirubin UDP-glucuronosyltransferase 1 in Gilbert's syndrome

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7 January 2021

Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor

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7 January 2021

Nuclear pregnane x receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxification

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7 January 2021

Nuclear Receptors Orchestrate Detoxification Pathways

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7 January 2021

The phenobarbital response enhancer module in the human bilirubin UDP-glucuronosyltransferase UGT1A1 gene and regulation by the nuclear receptor CAR.

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7 January 2021

Induction of bilirubin clearance by the constitutive androstane receptor (CAR)

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7 January 2021

A traditional herbal medicine enhances bilirubin clearance by activating the nuclear receptor CAR.

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7 January 2021

Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CAR

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7 January 2021

Humanized xenobiotic response in mice expressing nuclear receptor SXR.

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7 January 2021

The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism

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7 January 2021

A novel constitutive androstane receptor-mediated and CYP3A-independent pathway of bile acid detoxification

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7 January 2021

Regulation of a xenobiotic sulfonation cascade by nuclear pregnane X receptor (PXR).

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7 January 2021

Disrupted bile acid homeostasis reveals an unexpected interaction among nuclear hormone receptors, transporters, and cytochrome P450.

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7 January 2021

An exon 10 deletion in the mouse ferrochelatase gene has a dominant-negative effect and causes mild protoporphyria

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7 January 2021

Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor

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7 January 2021

Androstane metabolites bind to and deactivate the nuclear receptor CAR-beta

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7 January 2021

CAT constructions with multiple unique restriction sites for the functional analysis of eukaryotic promoters and regulatory elements

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7 January 2021

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions

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7 January 2021

Constitutive activation of transcription and binding of coactivator by estrogen-related receptors 1 and 2

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7 January 2021

Vitamin D receptor as an intestinal bile acid sensor

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7 January 2021

Combined loss of orphan receptors PXR and CAR heightens sensitivity to toxic bile acids in mice

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7 January 2021

Hepatic secretion of conjugated drugs and endogenous substances

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7 January 2021

A structural model of the constitutive androstane receptor defines novel interactions that mediate ligand-independent activity

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7 January 2021

An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids.

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7 January 2021

Differential transactivation by two isoforms of the orphan nuclear hormone receptor CAR

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7 January 2021

The xenobiotic compound 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene is an agonist ligand for the nuclear receptor CAR

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7 January 2021

Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands

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7 January 2021

CAR, driving into the future

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7 January 2021

Involvement of the xenobiotic response element (XRE) in Ah receptor-mediated induction of human UDP-glucuronosyltransferase 1A1.

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7 January 2021

In vitro induction of bilirubin conjugation in primary rat hepatocyte culture

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7 January 2021

The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity

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7 January 2021

The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux

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7 January 2021

Putative role of the orphan nuclear receptor SXR (steroid and xenobiotic receptor) in the mechanism of CYP3A4 inhibition by xenobiotics

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7 January 2021

Identifiers

DOI

10.1002/HEP.20570

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11 December 2017

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