(Q45286392)

English

High beta-secretase activity elicits neurodegeneration in transgenic mice despite reductions in amyloid-beta levels: implications for the treatment of Alzheimer disease

scientific article published on 15 July 2005

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scholarly article

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Europe PubMed Central

PubMed publication ID

11 December 2017

High beta-secretase activity elicits neurodegeneration in transgenic mice despite reductions in amyloid-beta levels: implications for the treatment of Alzheimer disease (English)

1 reference

Europe PubMed Central

PubMed publication ID

11 December 2017

Alzheimer's disease

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neurodegeneration

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based on heuristic

inferred from title

5

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Europe PubMed Central

PubMed publication ID

11 December 2017

Edward Rockenstein

1

object named as

Edward Rockenstein

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Europe PubMed Central

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11 December 2017

Eliezer Masliah

9

object named as

Eliezer Masliah

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Europe PubMed Central

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11 December 2017

8

object named as

Lennart Mucke

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Europe PubMed Central

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11 December 2017

author name string

Michael Mante

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Europe PubMed Central

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11 December 2017

Michael Alford

3

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Europe PubMed Central

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11 December 2017

Anthony Adame

4

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Europe PubMed Central

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11 December 2017

Makoto Hashimoto

6

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Europe PubMed Central

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11 December 2017

Luke Esposito

7

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11 December 2017

language of work or name

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publication date

15 July 2005

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Europe PubMed Central

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11 December 2017

Journal of Biological Chemistry

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Europe PubMed Central

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11 December 2017

280

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11 December 2017

38

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11 December 2017

32957-32967

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Europe PubMed Central

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11 December 2017

APP processing and synaptic function

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507016200

21 January 2018

Alzheimer's disease: molecular understanding predicts amyloid-based therapeutics

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507016200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507016200

21 January 2018

Purification and cloning of amyloid precursor protein beta-secretase from human brain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507016200

21 January 2018

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507016200

21 January 2018

BACE1 is the major beta-secretase for generation of Abeta peptides by neurons

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507016200

21 January 2018

Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507016200

21 January 2018

Emerging Alzheimer's disease therapies: inhibition of beta-secretase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507016200

21 January 2018

Intramembrane proteolysis by presenilin and presenilin-like proteases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507016200

21 January 2018

Putative function of ADAM9, ADAM10, and ADAM17 as APP alpha-secretase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507016200

21 January 2018

Alzheimer's beta-secretase, beta-site amyloid precursor protein-cleaving enzyme, is responsible for cleavage secretion of a Golgi-resident sialyltransferase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507016200

21 January 2018

Polymorphism in the BACE gene influences the risk for Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507016200

21 January 2018

Increased expression of the amyloid precursor beta-secretase in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507016200

21 January 2018

Beta-secretase processing in the trans-Golgi network preferentially generates truncated amyloid species that accumulate in Alzheimer's disease brain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507016200

21 January 2018

Neuronal and glial beta-secretase (BACE) protein expression in transgenic Tg2576 mice with amyloid plaque pathology

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507016200

21 January 2018

Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507016200

21 January 2018

Amyloid beta peptide load is correlated with increased beta-secretase activity in sporadic Alzheimer's disease patients

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507016200

21 January 2018

BACE overexpression alters the subcellular processing of APP and inhibits Abeta deposition in vivo

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507016200

21 January 2018

Expression of human beta-secretase in the mouse brain increases the steady-state level of beta-amyloid.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507016200

21 January 2018

Altered amyloid-beta metabolism and deposition in genomic-based beta-secretase transgenic mice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507016200

21 January 2018

BACE1 (beta-secretase) transgenic and knockout mice: identification of neurochemical deficits and behavioral changes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507016200

21 January 2018

Differential neuropathological alterations in transgenic mice expressing alpha-synuclein from the platelet-derived growth factor and Thy-1 promoters

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507016200

21 January 2018

Levels and alternative splicing of amyloid beta protein precursor (APP) transcripts in brains of APP transgenic mice and humans with Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507016200

21 January 2018

Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507016200

21 January 2018

Amyloid precursor protein processing and A beta42 deposition in a transgenic mouse model of Alzheimer disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507016200

21 January 2018

BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507016200

21 January 2018

beta-amyloid peptides enhance alpha-synuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer's disease and Parkinson's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507016200

21 January 2018

Astroglial expression of human alpha(1)-antichymotrypsin enhances alzheimer-like pathology in amyloid protein precursor transgenic mice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507016200

21 January 2018

Early formation of mature amyloid-beta protein deposits in a mutant APP transgenic model depends on levels of Abeta(1-42).

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507016200

21 January 2018

Mice deficient for the amyloid precursor protein gene.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507016200

21 January 2018

Carboxyl-terminal fragment of Alzheimer's APP destabilizes calcium homeostasis and renders neuronal cells vulnerable to excitotoxicity.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507016200

21 January 2018

Impairments in learning and memory accompanied by neurodegeneration in mice transgenic for the carboxyl-terminus of the amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507016200

21 January 2018

Transgenic BACE expression in mouse neurons accelerates amyloid plaque pathology

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507016200

21 January 2018

beta-site amyloid precursor protein cleaving enzyme 1 increases amyloid deposition in brain parenchyma but reduces cerebrovascular amyloid angiopathy in aging BACE x APP[V717I] double-transgenic mice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507016200

21 January 2018

Neuron-specific phosphorylation of Alzheimer's beta-amyloid precursor protein by cyclin-dependent kinase 5.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507016200

21 January 2018

Amyloid diseases: abnormal protein aggregation in neurodegeneration

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507016200

21 January 2018

Neural apoptosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507016200

21 January 2018

In vivo cleavage of alpha2,6-sialyltransferase by Alzheimer beta-secretase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507016200

21 January 2018

beta Subunits of voltage-gated sodium channels are novel substrates of beta-site amyloid precursor protein-cleaving enzyme (BACE1) and gamma-secretase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507016200

21 January 2018

Reductions in beta-amyloid concentrations in vivo by the gamma-secretase inhibitors BMS-289948 and BMS-299897.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507016200

21 January 2018

Rank-order of potencies for inhibition of the secretion of abeta40 and abeta42 suggests that both are generated by a single gamma-secretase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507016200

21 January 2018

Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507016200

21 January 2018

Evidence that beta-amyloid protein in Alzheimer's disease is not derived by normal processing

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507016200

21 January 2018

Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507016200

21 January 2018

Precursor of amyloid protein in Alzheimer disease undergoes fast anterograde axonal transport

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507016200

21 January 2018

Beta-amyloid precursor protein is detectable on monocytes and is increased in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507016200

21 January 2018

Isolation and quantification of soluble Alzheimer's beta-peptide from biological fluids

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507016200

21 January 2018

A phosphorylated, carboxy-terminal fragment of beta-amyloid precursor protein localizes to the splicing factor compartment

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507016200

21 January 2018

Identifiers

10.1074/JBC.M507016200

1 reference

Europe PubMed Central

PubMed publication ID

11 December 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

11 December 2017

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