(Q45290714)

11 December 2017

title

In vivo delivery of DN:REST improves transcriptional changes of REST-regulated genes in HD mice (English)

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11 December 2017

6

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11 December 2017

3

C Zuccato

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author name string

P Conforti

1

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11 December 2017

A Mas Monteys

2

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11 December 2017

C Zuccato

3

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11 December 2017

N J Buckley

4

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11 December 2017

B Davidson

5

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11 December 2017

publication date

15 November 2012

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11 December 2017

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11 December 2017

volume

20

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11 December 2017

issue

6

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11 December 2017

page(s)

678-685

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https://scigraph.springernature.com/pub.10.1038/gt.2012.84

11 December 2017

exact match

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cites work

The neuron-restrictive silencer factor (NRSF): a coordinate repressor of multiple neuron-specific genes

1 reference

https://api.crossref.org/works/10.1038%2FGT.2012.84

REST: a mammalian silencer protein that restricts sodium channel gene expression to neurons

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https://api.crossref.org/works/10.1038%2FGT.2012.84

Chromatin crosstalk in development and disease: lessons from REST

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A small modulatory dsRNA specifies the fate of adult neural stem cells

21 January 2018

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Genome-wide analysis of repressor element 1 silencing transcription factor/neuron-restrictive silencing factor (REST/NRSF) target genes

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https://api.crossref.org/works/10.1038%2FGT.2012.84

Role of brain-derived neurotrophic factor in Huntington's disease

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https://api.crossref.org/works/10.1038%2FGT.2012.84

Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2012.84

Identification of the REST regulon reveals extensive transposable element-mediated binding site duplication

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2012.84

REST regulates distinct transcriptional networks in embryonic and neural stem cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FGT.2012.84

Genome-wide mapping of in vivo protein-DNA interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2012.84

The bifunctional microRNA miR-9/miR-9* regulates REST and CoREST and is downregulated in Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2012.84

Gene dysregulation in Huntington's disease: REST, microRNAs and beyond

21 January 2018

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https://api.crossref.org/works/10.1038%2FGT.2012.84

Transcriptional dysregulation of coding and non-coding genes in cellular models of Huntington's disease

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https://api.crossref.org/works/10.1038%2FGT.2012.84

Ischemic insults promote epigenetic reprogramming of mu opioid receptor expression in hippocampal neurons

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https://api.crossref.org/works/10.1038%2FGT.2012.84

The neuronal repressor REST/NRSF is an essential regulator in medulloblastoma cells.

21 January 2018

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A genetic screen for candidate tumor suppressors identifies REST

21 January 2018

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Transcriptional regulation: cancer, neurons and the REST

21 January 2018

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https://api.crossref.org/works/10.1038%2FGT.2012.84

Expression and functions of the repressor element 1 (RE-1)-silencing transcription factor (REST) in breast cancer

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Neuronal target genes of the neuron-restrictive silencer factor in neurospheres derived from fetuses with Down's syndrome: a gene expression study

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DYRK1A-dosage imbalance perturbs NRSF/REST levels, deregulating pluripotency and embryonic stem cell fate in Down syndrome

21 January 2018

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https://api.crossref.org/works/10.1038%2FGT.2012.84

DYRK1A interacts with the REST/NRSF-SWI/SNF chromatin remodelling complex to deregulate gene clusters involved in the neuronal phenotypic traits of Down syndrome.

21 January 2018

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https://api.crossref.org/works/10.1038%2FGT.2012.84

REST in good times and bad: roles in tumor suppressor and oncogenic activities

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The repressor element 1-silencing transcription factor regulates heart-specific gene expression using multiple chromatin-modifying complexes

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2-Deoxy-D-glucose reduces epilepsy progression by NRSF-CtBP-dependent metabolic regulation of chromatin structure

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A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

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Molecular Mechanisms and Potential Therapeutical Targets in Huntington's Disease

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Huntingtin regulates RE1-silencing transcription factor/neuron-restrictive silencer factor (REST/NRSF) nuclear trafficking indirectly through a complex with REST/NRSF-interacting LIM domain protein (RILP) and dynactin p150 Glued

21 January 2018

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Widespread disruption of repressor element-1 silencing transcription factor/neuron-restrictive silencer factor occupancy at its target genes in Huntington's disease.

21 January 2018

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Regional and cellular gene expression changes in human Huntington's disease brain

21 January 2018

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Analysis of the repressor element-1 silencing transcription factor/neuron-restrictive silencer factor occupancy of non-neuronal genes in peripheral lymphocytes from patients with Huntington's disease

21 January 2018

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Brain-derived neurotrophic factor in neurodegenerative diseases

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A microRNA-based gene dysregulation pathway in Huntington's disease

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Rescue of gene expression by modified REST decoy oligonucleotides in a cellular model of Huntington's disease

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Loss of huntingtin function complemented by small molecules acting as repressor element 1/neuron restrictive silencer element silencer modulators

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SAR and QSAR study on 2-aminothiazole derivatives, modulators of transcriptional repression in Huntington's disease

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Full-length human mutant huntingtin with a stable polyglutamine repeat can elicit progressive and selective neuropathogenesis in BACHD mice

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Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtin

21 January 2018

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https://api.crossref.org/works/10.1038%2FGT.2012.84

Mouse and rat BDNF gene structure and expression revisited

21 January 2018

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21 January 2018

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https://api.crossref.org/works/10.1038%2FGT.2012.84

Nonallele-specific silencing of mutant and wild-type huntingtin demonstrates therapeutic efficacy in Huntington's disease mice.

21 January 2018

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https://api.crossref.org/works/10.1038%2FGT.2012.84

Gene therapy for Leber's congenital amaurosis is safe and effective through 1.5 years after vector administration

21 January 2018

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The human visual cortex responds to gene therapy-mediated recovery of retinal function

21 January 2018

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https://api.crossref.org/works/10.1038%2FGT.2012.84

Safety and tolerability of putaminal AADC gene therapy for Parkinson disease

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Safety and tolerability of gene therapy with an adeno-associated virus (AAV) borne GAD gene for Parkinson's disease: an open label, phase I trial

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https://api.crossref.org/works/10.1038%2FGT.2012.84

Long-term clinical improvement in MPTP-lesioned primates after gene therapy with AAV-hAADC.

21 January 2018

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https://api.crossref.org/works/10.1038%2FGT.2012.84

Functional correction of CNS phenotypes in a lysosomal storage disease model using adeno-associated virus type 4 vectors.

21 January 2018

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https://api.crossref.org/works/10.1038%2FGT.2012.84

Neuronal expression of zinc finger transcription factor REST/NRSF/XBR gene

21 January 2018

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https://api.crossref.org/works/10.1038%2FGT.2012.84

7 January 2021

Ethanol-induced neurodegeneration in NRSF/REST neuronal conditional knockout mice

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https://api.crossref.org/works/10.1038%2FGT.2012.84

7 January 2021

Ischemic insults derepress the gene silencer REST in neurons destined to die

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https://api.crossref.org/works/10.1038%2FGT.2012.84

7 January 2021

Roles of intercellular adhesion molecule-1 in hypertensive cardiac remodeling

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https://api.crossref.org/works/10.1038%2FGT.2012.84

7 January 2021

A gene network regulating lysosomal biogenesis and function

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https://api.crossref.org/works/10.1038%2FGT.2012.84

7 January 2021

A controlled trial of recombinant methionyl human BDNF in ALS: The BDNF Study Group (Phase III)

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https://api.crossref.org/works/10.1038%2FGT.2012.84

7 January 2021

Lack of huntingtin promotes neural stem cells differentiation into glial cells while neurons expressing huntingtin with expanded polyglutamine tracts undergo cell death

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https://api.crossref.org/works/10.1038%2FGT.2012.84

7 January 2021

Identifiers

DOI

10.1038/GT.2012.84

1 reference

Dimensions Publication ID

11 December 2017

1008862455

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1 reference