(Q45296120)

11 December 2017

title

Metabotropic glutamate receptor 5 knockout promotes motor and biochemical alterations in a mouse model of Huntington's disease (English)

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11 December 2017

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1

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11 December 2017

Rebecca A Devries

2

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11 December 2017

Alison Hamilton

3

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11 December 2017

Isabella M Guimaraes

4

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11 December 2017

Sean P Cregan

5

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11 December 2017

Rita G W Pires

6

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11 December 2017

Stephen S G Ferguson

7

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11 December 2017

language of work or name

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26 November 2013

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11 December 2017

published in

Human Molecular Genetics

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11 December 2017

volume

23

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11 December 2017

issue

8

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11 December 2017

page(s)

2030-2042

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Huntingtin-protein interactions and the pathogenesis of Huntington's disease

11 December 2017

cites work

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A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

21 January 2018

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Topography of enkephalin, substance P and acetylcholinesterase staining in Huntington's disease striatum

21 January 2018

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Sparing of acetylcholinesterase-containing striatal neurons in Huntington's disease

21 January 2018

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The organization of the basal ganglia-thalamocortical circuits: open interconnected rather than closed segregated

21 January 2018

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Glutamate and GABA receptors and transporters in the basal ganglia: what does their subsynaptic localization reveal about their function?

21 January 2018

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Clozapine reverses schizophrenia-related behaviours in the metabotropic glutamate receptor 5 knockout mouse: association with N-methyl-D-aspartic acid receptor up-regulation

21 January 2018

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Effect of the mGluR5 antagonist 6-methyl-2-(phenylethynyl)pyridine (MPEP) on the acute locomotor stimulant properties of cocaine, D-amphetamine, and the dopamine reuptake inhibitor GBR12909 in mice

21 January 2018

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PI3 kinase enhancer–Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis

21 January 2018

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Activation of the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin signaling pathway is required for metabotropic glutamate receptor-dependent long-term depression.

21 January 2018

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The scaffold protein Homer1b/c links metabotropic glutamate receptor 5 to extracellular signal-regulated protein kinase cascades in neurons

21 January 2018

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Inhibition of metabotropic glutamate receptor signaling by the huntingtin-binding protein optineurin

21 January 2018

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The metabotropic glutamate receptor 5 antagonist MPEP and the mGluR2 agonist LY379268 modify disease progression in a transgenic mouse model of Huntington's disease

21 January 2018

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Metabotropic glutamate receptor 5 positive allosteric modulators are neuroprotective in a mouse model of Huntington's disease

21 January 2018

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Metabotropic glutamate receptor-mediated cell signaling pathways are altered in a mouse model of Huntington's disease

21 January 2018

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Systematic behavioral evaluation of Huntington's disease transgenic and knock-in mouse models

21 January 2018

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The behavioral profile of the potent and selective mGlu5 receptor antagonist 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine (MTEP) in rodent models of anxiety

21 January 2018

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Long glutamine tracts cause nuclear localization of a novel form of huntingtin in medium spiny striatal neurons in HdhQ92 and HdhQ111 knock-in mice

21 January 2018

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Symptomatic treatment of Huntington disease

21 January 2018

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21 January 2018

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Phosphorylation-independent regulation of metabotropic glutamate receptor 5 desensitization and internalization by G protein-coupled receptor kinase 2 in neurons

21 January 2018

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Interaction between N-methyl-D-aspartic acid receptors and D1 dopamine receptors: an important mechanism for brain plasticity

21 January 2018

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In the rat medial nucleus accumbens, hippocampal and catecholaminergic terminals converge on spiny neurons and are in apposition to each other

21 January 2018

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Modulation of dopamine neuronal activity by glutamate receptor subtypes

21 January 2018

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Neurological abnormalities in a knock-in mouse model of Huntington's disease

21 January 2018

1 reference

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Transcriptional abnormalities in Huntington disease

21 January 2018

1 reference

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Dendritic spines elongate after stimulation of group 1 metabotropic glutamate receptors in cultured hippocampal neurons

21 January 2018

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Suppressing aberrant GluN3A expression rescues synaptic and behavioral impairments in Huntington's disease models

21 January 2018

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Axonal transport and neurodegenerative disease

21 January 2018

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Dynein mutations impair autophagic clearance of aggregate-prone proteins

21 January 2018

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Mutations in Caenorhabditis elegans cytoplasmic dynein components reveal specificity of neuronal retrograde cargo.

21 January 2018

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Behavioral and other phenotypes in a cytoplasmic Dynein light intermediate chain 1 mutant mouse

21 January 2018

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Length-dependent gametic CAG repeat instability in the Huntington's disease knock-in mouse

21 January 2018

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21 January 2018

Identifiers

DOI

10.1093/HMG/DDT598

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11 December 2017

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