(Q45303900)

11 December 2017

title

Increased PKA signaling disrupts recognition memory and spatial memory: role in Huntington's disease (English)

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11 December 2017

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11 December 2017

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11 December 2017

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11 December 2017

Esther Pérez-Navarro

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author name string

Ana Saavedra

series ordinal

2

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11 December 2017

Olga Carretón

series ordinal

3

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11 December 2017

publication date

11 August 2011

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11 December 2017

published in

Human Molecular Genetics

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11 December 2017

volume

20

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11 December 2017

issue

21

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11 December 2017

page(s)

4232-4247

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A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

11 December 2017

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21 January 2018

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If phosphatases go up, memory goes down

21 January 2018

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Phosphorylation and activation of cAMP-dependent protein kinase by phosphoinositide-dependent protein kinase

21 January 2018

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Regulation of NMDA receptors by phosphorylation

21 January 2018

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Impaired spatial working memory but spared spatial reference memory following functional loss of NMDA receptors in the dentate gyrus

21 January 2018

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Characterization of protein kinase A and protein kinase C phosphorylation of the N-methyl-D-aspartate receptor NR1 subunit using phosphorylation site-specific antibodies.

21 January 2018

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A role for the Ras signalling pathway in synaptic transmission and long-term memory

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Altered brain neurotransmitter receptors in transgenic mice expressing a portion of an abnormal human huntington disease gene

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Brain-derived neurotrophic factor regulates the onset and severity of motor dysfunction associated with enkephalinergic neuronal degeneration in Huntington's disease.

21 January 2018

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A mechanistic and kinetic analysis of the interactions of the diastereoisomers of adenosine 3',5'-(cyclic)phosphorothioate with purified cyclic AMP-dependent protein kinase

21 January 2018

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Up-regulating BDNF with an ampakine rescues synaptic plasticity and memory in Huntington's disease knockin mice

21 January 2018

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Gene-environment interactions modulating cognitive function and molecular correlates of synaptic plasticity in Huntington's disease transgenic mice.

21 January 2018

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Involvement of hippocampal cAMP/cAMP-dependent protein kinase signaling pathways in a late memory consolidation phase of aversively motivated learning in rats

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Constitutive activation of the G-protein subunit Galphas within forebrain neurons causes PKA-dependent alterations in fear conditioning and cortical Arc mRNA expression.

21 January 2018

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Removal of G(ialpha1) constraints on adenylyl cyclase in the hippocampus enhances LTP and impairs memory formation

21 January 2018

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21 January 2018

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21 January 2018

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Striatal phosphodiesterase mRNA and protein levels are reduced in Huntington's disease transgenic mice prior to the onset of motor symptoms

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDR351

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21 January 2018

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Enhanced long-term potentiation and impaired learning in phosphodiesterase 4D-knockout (PDE4D) mice

21 January 2018

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Ubiquitin hydrolase Uch-L1 rescues beta-amyloid-induced decreases in synaptic function and contextual memory

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR351

Inhibition of phosphodiesterase-4 reverses memory deficits produced by Aβ25-35 or Aβ1-40 peptide in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR351

Persistent improvement in synaptic and cognitive functions in an Alzheimer mouse model after rolipram treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR351

Regulation of hippocampal synaptic plasticity by cyclic AMP-dependent protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR351

Phosphorylation of the Ras-GRF1 exchange factor at Ser916/898 reveals activation of Ras signaling in the cerebral cortex

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR351

Striatal-enriched protein-tyrosine-phosphatase, synaptic plasticity, and psychostimulant-induced stereotypies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR351

A protein factor essential for microtubule assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR351

Cyclic nucleotide phosphodiesterases: molecular regulation to clinical use

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR351

Specificity and spatial dynamics of protein kinase A signaling organized by A-kinase-anchoring proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR351

Activation of mGluRII induces LTD via activation of protein kinase A and protein kinase C in the dentate gyrus of the hippocampus in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR351

Mitogen-activated protein kinase-mediated reinforcement of hippocampal early long-term depression by the type IV-specific phosphodiesterase inhibitor rolipram and its effect on synaptic tagging.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR351

Distinct roles for Ras-guanine nucleotide-releasing factor 1 (Ras-GRF1) and Ras-GRF2 in the induction of long-term potentiation and long-term depression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR351

Neuronal vulnerability in mouse models of Huntington's disease: membrane channel protein changes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR351

Striatal-enriched protein tyrosine phosphatase expression and activity in Huntington's disease: a STEP in the resistance to excitotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR351

Disruption of striatal glutamatergic transmission induced by mutant huntingtin involves remodeling of both postsynaptic density and NMDA receptor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR351

Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR351

PH domain leucine-rich repeat protein phosphatase 1 contributes to maintain the activation of the PI3K/Akt pro-survival pathway in Huntington's disease striatum.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR351

Reduced calcineurin protein levels and activity in exon-1 mouse models of Huntington's disease: role in excitotoxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR351

BH3-only proteins Bid and Bim(EL) are differentially involved in neuronal dysfunction in mouse models of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR351

Binding of a nuclear protein to the cyclic-AMP response element of the somatostatin gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR351

21 January 2018

Identifiers

DOI

10.1093/HMG/DDR351

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11 December 2017

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