(Q45850976)

16 December 2017

title

Phase II trial of RAD001 and bicalutamide for castration-resistant prostate cancer (English)

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16 December 2017

main subject

phase II clinical trial

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4

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16 December 2017

William K. Oh

5

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16 December 2017

Philip W. Kantoff

11

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16 December 2017

Mary-Ellen Taplin

12

object named as

Mary-Ellen Taplin

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16 December 2017

Mari Nakabayashi

1

object named as

Mari Nakabayashi

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16 December 2017

author name string

Lilian Werner

2

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16 December 2017

Kevin D Courtney

3

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16 December 2017

Glen J Bubley

6

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16 December 2017

Julia H Hayes

7

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16 December 2017

Douglas Weckstein

8

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16 December 2017

Aymen Elfiky

9

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16 December 2017

Danny M Sims

10

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16 December 2017

publication date

29 August 2012

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16 December 2017

published in

BJU International

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16 December 2017

volume

110

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16 December 2017

issue

11

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16 December 2017

page(s)

1729-1735

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16 December 2017

Drug insight: role of the androgen receptor in the development and progression of prostate cancer

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1 reference

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Phase II trial of bicalutamide in patients with advanced prostate cancer in whom conventional hormonal therapy failed: a Southwest Oncology Group study (SWOG 9235).

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Maintenance of intratumoral androgens in metastatic prostate cancer: a mechanism for castration-resistant tumor growth

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Increased expression of genes converting adrenal androgens to testosterone in androgen-independent prostate cancer

21 January 2018

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Intratumoral androgen biosynthesis in prostate cancer pathogenesis and response to therapy

21 January 2018

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Intratumoral de novo steroid synthesis activates androgen receptor in castration-resistant prostate cancer and is upregulated by treatment with CYP17A1 inhibitors

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PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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mTOR inhibitor RAD001 (everolimus) has antiangiogenic/vascular properties distinct from a VEGFR tyrosine kinase inhibitor

21 January 2018

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Phase 3 trial of everolimus for metastatic renal cell carcinoma : final results and analysis of prognostic factors

21 January 2018

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Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial

21 January 2018

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mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways

21 January 2018

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An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Ras, PI(3)K and mTOR signalling controls tumour cell growth

21 January 2018

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21 January 2018

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21 January 2018

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mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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PIK3CA mutation, but not PTEN loss of function, determines the sensitivity of breast cancer cells to mTOR inhibitory drugs

21 January 2018

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21 January 2018

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21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1464-410X.2012.11456.X

10.1111/J.1464-410X.2012.11456.X

21 January 2018

Identifiers

DOI

1 reference

16 December 2017

PubMed ID

22928480

1 reference

16 December 2017