(Q45908190)

English

Polypharmacology of sulfonamides: pazopanib, a multitargeted receptor tyrosine kinase inhibitor in clinical use, potently inhibits several mammalian carbonic anhydrases.

scientific article published on 26 June 2012

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

17 December 2017

http://europepmc.org/abstract/MED/22733110

Polypharmacology of sulfonamides: pazopanib, a multitargeted receptor tyrosine kinase inhibitor in clinical use, potently inhibits several mammalian carbonic anhydrases. (English)

1 reference

Europe PubMed Central

PubMed publication ID

17 December 2017

http://europepmc.org/abstract/MED/22733110

1 reference

ChEBI release 2020-05-28

Andrea Scozzafava

4

1 reference

Europe PubMed Central

PubMed publication ID

17 December 2017

http://europepmc.org/abstract/MED/22733110

Claudiu T Supuran

5

object named as

Claudiu T Supuran

1 reference

Europe PubMed Central

PubMed publication ID

17 December 2017

http://europepmc.org/abstract/MED/22733110

author name string

Jean-Yves Winum

1

1 reference

Europe PubMed Central

PubMed publication ID

17 December 2017

http://europepmc.org/abstract/MED/22733110

Alfonso Maresca

2

1 reference

Europe PubMed Central

PubMed publication ID

17 December 2017

http://europepmc.org/abstract/MED/22733110

Fabrizio Carta

3

1 reference

Europe PubMed Central

PubMed publication ID

17 December 2017

http://europepmc.org/abstract/MED/22733110

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publication date

26 June 2012

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Europe PubMed Central

PubMed publication ID

17 December 2017

http://europepmc.org/abstract/MED/22733110

Chemical Communications

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Europe PubMed Central

PubMed publication ID

17 December 2017

http://europepmc.org/abstract/MED/22733110

48

1 reference

Europe PubMed Central

PubMed publication ID

17 December 2017

http://europepmc.org/abstract/MED/22733110

66

1 reference

Europe PubMed Central

PubMed publication ID

17 December 2017

http://europepmc.org/abstract/MED/22733110

8177-8179

1 reference

Europe PubMed Central

PubMed publication ID

17 December 2017

http://europepmc.org/abstract/MED/22733110

Protein tyrosine kinase inhibitors: new treatment modalities?

1 reference

https://api.crossref.org/works/10.1039%2FC2CC33415A

21 January 2018

Pazopanib: Clinical development of a potent anti-angiogenic drug

1 reference

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21 January 2018

The therapy of kidney cancer with biomolecular drugs.

1 reference

https://api.crossref.org/works/10.1039%2FC2CC33415A

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CC33415A

21 January 2018

Carbonic anhydrases: novel therapeutic applications for inhibitors and activators

1 reference

https://api.crossref.org/works/10.1039%2FC2CC33415A

21 January 2018

Carbonic anhydrase inhibitors

1 reference

https://api.crossref.org/works/10.1039%2FC2CC33415A

21 January 2018

Interfering with pH regulation in tumours as a therapeutic strategy

1 reference

https://api.crossref.org/works/10.1039%2FC2CC33415A

21 January 2018

Selection of Carbonic Anhydrase IX Inhibitors from One Million DNA-Encoded Compounds

1 reference

https://api.crossref.org/works/10.1039%2FC2CC33415A

21 January 2018

Carbonic anhydrase inhibitors as anticonvulsant agents

1 reference

https://api.crossref.org/works/10.1039%2FC2CC33415A

21 January 2018

Carbonic anhydrase IX as an anticancer therapy target: preclinical evaluation of internalizing monoclonal antibody directed to catalytic domain

1 reference

https://api.crossref.org/works/10.1039%2FC2CC33415A

21 January 2018

Imaging of CA IX with fluorescent labelled sulfonamides distinguishes hypoxic and (re)-oxygenated cells in a xenograft tumour model

1 reference

https://api.crossref.org/works/10.1039%2FC2CC33415A

21 January 2018

In vivo targeting of tumor-associated carbonic anhydrases using acetazolamide derivatives

1 reference

https://api.crossref.org/works/10.1039%2FC2CC33415A

21 January 2018

Carbonic anhydrase inhibitors. Zonisamide is an effective inhibitor of the cytosolic isozyme II and mitochondrial isozyme V: solution and X-ray crystallographic studies.

1 reference

https://api.crossref.org/works/10.1039%2FC2CC33415A

21 January 2018

Carbonic anhydrase inhibitors: X-ray crystallographic studies for the binding of N-substituted benzenesulfonamides to human isoform II

1 reference

https://api.crossref.org/works/10.1039%2FC2CC33415A

21 January 2018

Dithiocarbamates: a new class of carbonic anhydrase inhibitors. Crystallographic and kinetic investigations

1 reference

https://api.crossref.org/works/10.1039%2FC2CC33415A

21 January 2018

Targeting tumor hypoxia: suppression of breast tumor growth and metastasis by novel carbonic anhydrase IX inhibitors.

1 reference

https://api.crossref.org/works/10.1039%2FC2CC33415A

21 January 2018

Ureido-substituted benzenesulfonamides potently inhibit carbonic anhydrase IX and show antimetastatic activity in a model of breast cancer metastasis.

1 reference

https://api.crossref.org/works/10.1039%2FC2CC33415A

21 January 2018

Recent developments in targeting carbonic anhydrase IX for cancer therapeutics

1 reference

https://api.crossref.org/works/10.1039%2FC2CC33415A

21 January 2018

Anticancer and antiviral sulfonamides

1 reference

https://api.crossref.org/works/10.1039%2FC2CC33415A

21 January 2018

Indisulam: an anticancer sulfonamide in clinical development

1 reference

https://api.crossref.org/works/10.1039%2FC2CC33415A

21 January 2018

Carbonic anhydrase inhibitors: E7070, a sulfonamide anticancer agent, potently inhibits cytosolic isozymes I and II, and transmembrane, tumor-associated isozyme IX.

1 reference

https://api.crossref.org/works/10.1039%2FC2CC33415A

21 January 2018

Carbonic anhydrase inhibitors: cloning, characterization, and inhibition studies of the cytosolic isozyme III with sulfonamides

1 reference

https://api.crossref.org/works/10.1039%2FC2CC33415A

21 January 2018

Selective hydrophobic pocket binding observed within the carbonic anhydrase II active site accommodate different 4-substituted-ureido-benzenesulfonamides and correlate to inhibitor potency

1 reference

https://api.crossref.org/works/10.1039%2FC2CC33415A

21 January 2018

Non-zinc mediated inhibition of carbonic anhydrases: coumarins are a new class of suicide inhibitors

1 reference

https://api.crossref.org/works/10.1039%2FC2CC33415A

21 January 2018

Carbonic anhydrase inhibitors. The X-ray crystal structure of human isoform II in adduct with an adamantyl analogue of acetazolamide resides in a less utilized binding pocket than most hydrophobic inhibitors

1 reference

https://api.crossref.org/works/10.1039%2FC2CC33415A

21 January 2018

Carbonic anhydrase inhibitors: crystallographic and solution binding studies for the interaction of a boron-containing aromatic sulfamide with mammalian isoforms I-XV

1 reference

https://api.crossref.org/works/10.1039%2FC2CC33415A

21 January 2018

Coumarinyl-substituted sulfonamides strongly inhibit several human carbonic anhydrase isoforms: solution and crystallographic investigations

1 reference

https://api.crossref.org/works/10.1039%2FC2CC33415A

21 January 2018

Molecular mechanisms of carbonic anhydrase IX-mediated pH regulation under hypoxia

1 reference

https://api.crossref.org/works/10.1039%2FC2CC33415A

21 January 2018

Protein tyrosine kinase inhibitors as anticancer agents

1 reference

https://api.crossref.org/works/10.1039%2FC2CC33415A

21 January 2018

Carbonic Anhydrase Inhibitors: Water-Soluble 4-Sulfamoylphenylthioureas as Topical Intraocular Pressure-Lowering Agents with Long-Lasting Effects

1 reference

https://api.crossref.org/works/10.1039%2FC2CC33415A

21 January 2018

Carbonic Anhydrase Inhibitors: Clash with Ala65 as a Means for Designing Inhibitors with Low Affinity for the Ubiquitous Isozyme II, Exemplified by the Crystal Structure of the Topiramate Sulfamide Analogue†

1 reference

https://api.crossref.org/works/10.1039%2FC2CC33415A

21 January 2018

Identifiers

10.1039/C2CC33415A

1 reference

Europe PubMed Central

PubMed publication ID

17 December 2017

http://europepmc.org/abstract/MED/22733110

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

17 December 2017

http://europepmc.org/abstract/MED/22733110

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