(Q45947436)

18 December 2017

title

Development and applications of a broad-coverage, TR-FRET-based kinase binding assay platform. (English)

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18 December 2017

author name string

Connie S Lebakken

1

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18 December 2017

Steven M Riddle

2

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18 December 2017

Upinder Singh

3

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18 December 2017

W Jack Frazee

4

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18 December 2017

Hildegard C Eliason

5

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18 December 2017

Yi Gao

6

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18 December 2017

Laurie J Reichling

7

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18 December 2017

Bryan D Marks

8

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18 December 2017

Kurt W Vogel

9

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18 December 2017

publication date

29 June 2009

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18 December 2017

Journal of Biomolecular Screening

published in

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18 December 2017

volume

14

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18 December 2017

issue

8

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18 December 2017

page(s)

924-935

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18 December 2017

Fluorescent cascade and direct assays for characterization of RAF signaling pathway inhibitors

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Three mechanistically distinct kinase assays compared: Measurement of intrinsic ATPase activity identified the most comprehensive set of ITK inhibitors

21 January 2018

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Structures of Lung Cancer-Derived EGFR Mutants and Inhibitor Complexes: Mechanism of Activation and Insights into Differential Inhibitor Sensitivity

21 January 2018

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A small molecule-kinase interaction map for clinical kinase inhibitors

21 January 2018

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A High-Throughput, Nonisotopic, Competitive Binding Assay for Kinases Using Nonselective Inhibitor Probes (ED-NSIP™)

21 January 2018

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Quantitative chemical proteomics reveals mechanisms of action of clinical ABL kinase inhibitors

21 January 2018

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Functional interrogation of the kinome using nucleotide acyl phosphates

21 January 2018

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Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site

21 January 2018

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Time-resolved Forster resonance energy transfer assays for the binding of nucleotide and protein substrates to p38alpha protein kinase

21 January 2018

1 reference

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Fluorescence polarization competition assay: the range of resolvable inhibitor potency is limited by the affinity of the fluorescent ligand

21 January 2018

1 reference

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Time-resolved fluorescence resonance energy transfer kinase assays using physiological protein substrates: applications of terbium-fluorescein and terbium-green fluorescent protein fluorescence resonance energy transfer pairs.

21 January 2018

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Structural mechanism for STI-571 inhibition of abelson tyrosine kinase

21 January 2018

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Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

21 January 2018

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Diffusion-enhanced fluorescence energy transfer

21 January 2018

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Creating chemical diversity to target protein kinases

21 January 2018

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Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF

21 January 2018

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BIRB796 inhibits all p38 MAPK isoforms in vitro and in vivo.

21 January 2018

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The kinetics of binding to p38MAP kinase by analogues of BIRB 796.

21 January 2018

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Thermal denaturation: a method to rank slow binding, high-affinity P38alpha MAP kinase inhibitors

21 January 2018

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The discovery of potent cRaf1 kinase inhibitors

21 January 2018

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Oxindole-based inhibitors of cyclin-dependent kinase 2 (CDK2): design, synthesis, enzymatic activities, and X-ray crystallographic analysis

21 January 2018

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Paradoxical activation of Raf by a novel Raf inhibitor

21 January 2018

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Rational design of inhibitors that bind to inactive kinase conformations

21 January 2018

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Small molecule modulators of cyclin-dependent kinases for cancer therapy

21 January 2018

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E2F1 represses beta-catenin transcription and is antagonized by both pRB and CDK8

21 January 2018

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CDK8 is a colorectal cancer oncogene that regulates beta-catenin activity

21 January 2018

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A proteome-wide CDK/CRK-specific kinase inhibitor promotes tumor cell death in the absence of cell cycle progression

21 January 2018

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2-Anilino-4-(thiazol-5-yl)pyrimidine CDK inhibitors: synthesis, SAR analysis, X-ray crystallography, and biological activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057109339207

A quantitative analysis of kinase inhibitor selectivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057109339207

A non-radioactive method for the assay of many serine/threonine-specific protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057109339207

A unique structure for epidermal growth factor receptor bound to GW572016 (Lapatinib): relationships among protein conformation, inhibitor off-rate, and receptor activity in tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057109339207

Cell surface distribution of lectin receptors determined by resonance energy transfer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057109339207

21 January 2018

Identifiers

DOI

10.1177/1087057109339207

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18 December 2017

1 reference

18 December 2017