(Q46035772)

English

Genomic and proteomic study to survey the mechanism of action of the anti-Parkinson's disease drug, rasagiline compared with selegiline, in the rat midbrain.

scientific article published on 25 April 2009

Genomic and proteomic study to survey the mechanism of action of the anti-Parkinson’s disease drug, rasagiline compared with selegiline, in the rat midbrain

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scholarly article

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Europe PubMed Central

PubMed publication ID

18 December 2017

http://europepmc.org/abstract/MED/19396396

Genomic and proteomic study to survey the mechanism of action of the anti-Parkinson's disease drug, rasagiline compared with selegiline, in the rat midbrain. (English)

1 reference

Europe PubMed Central

PubMed publication ID

18 December 2017

http://europepmc.org/abstract/MED/19396396

1 reference

based on heuristic

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Moussa B. H. Youdim

5

object named as

Moussa B H Youdim

1 reference

Europe PubMed Central

PubMed publication ID

18 December 2017

http://europepmc.org/abstract/MED/19396396

1

object named as

Orly Weinreb

1 reference

Europe PubMed Central

PubMed publication ID

18 December 2017

http://europepmc.org/abstract/MED/19396396

4

object named as

Noam Drigues

1 reference

Europe PubMed Central

PubMed publication ID

18 December 2017

http://europepmc.org/abstract/MED/19396396

author name string

Tamar Amit

2

1 reference

Europe PubMed Central

PubMed publication ID

18 December 2017

http://europepmc.org/abstract/MED/19396396

Yotam Sagi

3

1 reference

Europe PubMed Central

PubMed publication ID

18 December 2017

http://europepmc.org/abstract/MED/19396396

publication date

25 April 2009

1 reference

Europe PubMed Central

PubMed publication ID

18 December 2017

http://europepmc.org/abstract/MED/19396396

Journal of Neural Transmission

1 reference

Europe PubMed Central

PubMed publication ID

18 December 2017

http://europepmc.org/abstract/MED/19396396

116

1 reference

Europe PubMed Central

PubMed publication ID

18 December 2017

http://europepmc.org/abstract/MED/19396396

11

1 reference

Europe PubMed Central

PubMed publication ID

18 December 2017

http://europepmc.org/abstract/MED/19396396

1457-1472

1 reference

Europe PubMed Central

PubMed publication ID

18 December 2017

http://europepmc.org/abstract/MED/19396396

https://scigraph.springernature.com/pub.10.1007/s00702-009-0225-x

0 references

Neuroprotection by rasagiline: a new therapeutic approach to Parkinson's disease?

1 reference

https://api.crossref.org/works/10.1007%2FS00702-009-0225-X

21 January 2018

Modification of blood pressure and nictitating membrane response to sympathetic amines by selective monoamine oxidase inhibitors, types A and B, in the cat.

1 reference

https://api.crossref.org/works/10.1007%2FS00702-009-0225-X

21 January 2018

Clinical trials of neuroprotection for Parkinson's disease

1 reference

https://api.crossref.org/works/10.1007%2FS00702-009-0225-X

21 January 2018

Recent progress in studies of neurotrophic factors and their clinical implications

1 reference

https://api.crossref.org/works/10.1007%2FS00702-009-0225-X

21 January 2018

A review of the mechanisms and role of monoamine oxidase inhibitors in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1007%2FS00702-009-0225-X

21 January 2018

Comprehensive review of rasagiline, a second-generation monoamine oxidase inhibitor, for the treatment of Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19396396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Crystal structures of monoamine oxidase B in complex with four inhibitors of the N-propargylaminoindan class

1 reference

https://pubmed.ncbi.nlm.nih.gov/19396396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

14-3-3 proteins in the nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/19396396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The path from anti Parkinson drug selegiline and rasagiline to multifunctional neuroprotective anti Alzheimer drugs ladostigil and m30.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19396396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BDNF and the diseased nervous system: a delicate balance between adaptive and pathological processes of gene regulation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19396396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroprotective effect of rasagiline in a rodent model of Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19396396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A controlled trial of rasagiline in early Parkinson disease: the TEMPO Study

1 reference

https://pubmed.ncbi.nlm.nih.gov/19396396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

On the mode of action of L-deprenyl in the human central nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/19396396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Contrasting neuroprotective and neurotoxic actions of respective metabolites of anti-Parkinson drugs rasagiline and selegiline

1 reference

https://pubmed.ncbi.nlm.nih.gov/19396396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An interim report of the effect of selegiline (L-deprenyl) on the progression of disability in early Parkinson's disease. The Parkinson Study Group

1 reference

https://pubmed.ncbi.nlm.nih.gov/19396396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A randomized, double-blind, placebo-controlled, delayed start study to assess rasagiline as a disease modifying therapy in Parkinson's disease (the ADAGIO study): rationale, design, and baseline characteristics

1 reference

https://pubmed.ncbi.nlm.nih.gov/19396396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deprenyl enhances neurite outgrowth in cultured rat spinal ventral horn neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/19396396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rasagiline Mesylate, a New Mao-B Inhibitor for the Treatment of Parkinson's Disease: A Double-Blind Study as Adjunctive Therapy to Levodopa

1 reference

https://pubmed.ncbi.nlm.nih.gov/19396396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of multiple survival signal transduction pathways in the neuroprotective, neurorescue and APP processing activity of rasagiline and its propargyl moiety

1 reference

https://pubmed.ncbi.nlm.nih.gov/19396396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroprotection by propargylamines in Parkinson's disease: suppression of apoptosis and induction of prosurvival genes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19396396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synaptotagmin IV does not alter excitatory fast synaptic transmission or fusion pore kinetics in mammalian CNS neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/19396396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Computational analysis of microarray data

1 reference

https://pubmed.ncbi.nlm.nih.gov/19396396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of Bcl-2 family proteins, neurotrophic factors, and APP processing in the neurorescue activity of propargylamine

1 reference

https://pubmed.ncbi.nlm.nih.gov/19396396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Some puzzling pharmacological effects of monoamine oxidase inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/19396396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long-term effects of L-deprenyl in chronic levodopa treated parkinsonian patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/19396396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased life expectancy resulting from addition of L-deprenyl to Madopar treatment in Parkinson's disease: a longterm study

1 reference

https://pubmed.ncbi.nlm.nih.gov/19396396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroprotection via pro-survival protein kinase C isoforms associated with Bcl-2 family members

1 reference

https://pubmed.ncbi.nlm.nih.gov/19396396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein detection methods in proteomics research

1 reference

https://pubmed.ncbi.nlm.nih.gov/19396396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deprenyl in Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19396396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of N-propargyl-1-(R)aminoindan (rasagiline) in models of motor and cognition disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/19396396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metallothionein, neurotrophins and selegiline in providing neuroprotection in Parkinson's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19396396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long term treatment with (-)deprenyl reduces the optimal dose as well as the effective dose range for increasing antioxidant enzyme activities in old mouse brain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19396396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Propargylamines induce antiapoptotic new protein synthesis in serum- and nerve growth factor (NGF)-withdrawn, NGF-differentiated PC-12 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19396396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

(-)-Deprenyl reduces PC12 cell apoptosis by inducing new protein synthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19396396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of tyrosine kinase receptor signaling pathway by rasagiline facilitates neurorescue and restoration of nigrostriatal dopamine neurons in post-MPTP-induced parkinsonism

1 reference

https://pubmed.ncbi.nlm.nih.gov/19396396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1 reference

https://pubmed.ncbi.nlm.nih.gov/19396396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A randomized placebo-controlled trial of rasagiline in levodopa-treated patients with Parkinson disease and motor fluctuations: the PRESTO study

1 reference

https://pubmed.ncbi.nlm.nih.gov/19396396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuropharmacological, neuroprotective and amyloid precursor processing properties of selective MAO-B inhibitor antiparkinsonian drug, rasagiline

1 reference

https://pubmed.ncbi.nlm.nih.gov/19396396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

(R)(+)-N-propargyl-1-aminoindan (rasagiline) and derivatives: highly selective and potent inhibitors of monoamine oxidase B.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19396396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Practical importance of neuroprotection in Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19396396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anti-apoptotic and apoptotic action of (-)-deprenyl and its metabolites

1 reference

https://pubmed.ncbi.nlm.nih.gov/19396396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selegiline enhances NGF synthesis and protects central nervous system neurons from excitotoxic and ischemic damage.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19396396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antiparkinson efficacy of deprenyl. DATATOP Steering Committee of Parkinson Study Group

1 reference

https://pubmed.ncbi.nlm.nih.gov/19396396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhancing effect of rasagiline on superoxide dismutase and catalase activities in the dopaminergic system in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/19396396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Statistical issues with microarrays: processing and analysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19396396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rasagiline: A second-generation monoamine oxidase type-B inhibitor for the treatment of Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19396396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Implications of combined treatment with 'Madopar' and L-deprenil in Parkinson's disease. A long-term study

1 reference

https://pubmed.ncbi.nlm.nih.gov/19396396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Novel neuroprotective mechanism of action of rasagiline is associated with its propargyl moiety: interaction of Bcl-2 family members with PKC pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/19396396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of MAP kinase in the regulation of amyloid precursor protein processing by novel cholinesterase inhibitors derived from rasagiline

1 reference

https://pubmed.ncbi.nlm.nih.gov/19396396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Why (--)deprenyl prolongs survivals of experimental animals: increase of anti-oxidant enzymes in brain and other body tissues as well as mobilization of various humoral factors may lead to systemic anti-aging effects

1 reference

https://pubmed.ncbi.nlm.nih.gov/19396396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cardiovascular activity of rasagiline, a selective and potent inhibitor of mitochondrial monoamine oxidase B: comparison with selegiline.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19396396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A controlled, randomized, delayed-start study of rasagiline in early Parkinson disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19396396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gene and protein expression profiles of anti- and pro-apoptotic actions of dopamine, R-apomorphine, green tea polyphenol (-)-epigallocatechine-3-gallate, and melatonin

1 reference

https://pubmed.ncbi.nlm.nih.gov/19396396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DAVID: Database for Annotation, Visualization, and Integrated Discovery

1 reference

https://pubmed.ncbi.nlm.nih.gov/19396396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroprotective and neurotoxic effects of monoamine oxidase-B inhibitors and derived metabolites under ischemia in PC12 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19396396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rasagiline [N-propargyl-1R(+)-aminoindan], a selective and potent inhibitor of mitochondrial monoamine oxidase B

1 reference

https://pubmed.ncbi.nlm.nih.gov/19396396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Method to correlate tandem mass spectra of modified peptides to amino acid sequences in the protein database

1 reference

https://pubmed.ncbi.nlm.nih.gov/19396396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The application of proteomics and genomics to the study of age-related neurodegeneration and neuroprotection

1 reference

https://pubmed.ncbi.nlm.nih.gov/19396396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antiapoptotic properties of rasagiline, N-propargylamine-1(R)-aminoindan, and its optical (S)-isomer, TV1022.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19396396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial permeability transition mediates apoptosis induced by N-methyl(R)salsolinol, an endogenous neurotoxin, and is inhibited by Bcl-2 and rasagiline, N-propargyl-1(R)-aminoindan

1 reference

https://pubmed.ncbi.nlm.nih.gov/19396396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical pharmacology of rasagiline: a novel, second-generation propargylamine for the treatment of Parkinson disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19396396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dopaminergic supersensitivity in parkinsonism

1 reference

https://pubmed.ncbi.nlm.nih.gov/19396396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Trophic effects of selegiline on cultured dopaminergic neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/19396396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The neuronal survival effects of rasagiline and deprenyl on fetal human and rat ventral mesencephalic neurones in culture.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19396396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amphetamine and 2-phenylethylamine in post-mortem Parkinsonian brain after (-)deprenyl administration

1 reference

https://pubmed.ncbi.nlm.nih.gov/19396396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rat striatal monoamine oxidase-B inhibition by l-deprenyl and rasagiline: its relationship to 2-phenylethylamine-induced stereotypy and Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19396396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurotoxins induce apoptosis in dopamine neurons: protection by N-propargylamine-1(R)- and (S)-aminoindan, rasagiline and TV1022

1 reference

https://pubmed.ncbi.nlm.nih.gov/19396396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolism of deprenyl, a selective monoamine oxidase (MAO) B inhibitor in rat: relationship of metabolism to MAO-B inhibitory potency

1 reference

https://pubmed.ncbi.nlm.nih.gov/19396396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison of neuroprotective and neurorestorative capabilities of rasagiline and selegiline against lactacystin-induced nigrostriatal dopaminergic degeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/19396396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

(-)-Deprenyl leads to prolongation of L-dopa efficacy in Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19396396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The anti-Parkinson drug, rasagiline, prevents apoptotic DNA damage induced by peroxynitrite in human dopaminergic neuroblastoma SH-SY5Y cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19396396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A role for GAPDH in apoptosis and neurodegeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/19396396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An endogenous dopaminergic neurotoxin, N-methyl-(R)-salsolinol, induces DNA damage in human dopaminergic neuroblastoma SH-SY5Y cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19396396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Improving large-scale proteomics by clustering of mass spectrometry data.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19396396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Normalization of real-time quantitative reverse transcription-PCR data: a model-based variance estimation approach to identify genes suited for normalization, applied to bladder and colon cancer data sets

1 reference

https://pubmed.ncbi.nlm.nih.gov/19396396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aminoindan and hydroxyaminoindan, metabolites of rasagiline and ladostigil, respectively, exert neuroprotective properties in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/19396396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of tocopherol and deprenyl on the progression of disability in early Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19396396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of protein kinase C by the anti-Parkinson drug, MAO-B inhibitor, rasagiline and its derivatives, in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/19396396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MAO-B inhibitors: multiple roles in the therapy of neurodegenerative disorders?

1 reference

https://pubmed.ncbi.nlm.nih.gov/19396396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Monoamine oxidase B inhibitor selegiline protects young and aged rat peripheral sympathetic neurons against 6-hydroxydopamine-induced neurotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/19396396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Monoamine oxidase activity during (--)-deprenil therapy: human brain post-mortem studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/19396396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selegiline can mediate neuronal rescue rather than neuronal protection

1 reference

https://pubmed.ncbi.nlm.nih.gov/19396396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deprenyl: from chemical synthesis to neuroprotection

1 reference

https://pubmed.ncbi.nlm.nih.gov/19396396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biphasic effects of selegiline on striatal dopamine: lack of effect on methamphetamine-induced dopamine depletion

1 reference

https://pubmed.ncbi.nlm.nih.gov/19396396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroprotective actions of selegiline

1 reference

https://pubmed.ncbi.nlm.nih.gov/19396396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of deprenyl on the progression of disability in early Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19396396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rasagiline: neurodegeneration, neuroprotection, and mitochondrial permeability transition

1 reference

https://pubmed.ncbi.nlm.nih.gov/19396396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The importance of propargylamine moiety in the anti-Parkinson drug rasagiline and its derivatives in MAPK-dependent amyloid precursor protein processing

1 reference

https://pubmed.ncbi.nlm.nih.gov/19396396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00702-009-0225-X

1 reference

Europe PubMed Central

PubMed publication ID

18 December 2017

http://europepmc.org/abstract/MED/19396396

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

18 December 2017

http://europepmc.org/abstract/MED/19396396

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