(Q46207609)

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Limited mutations in full-length tetrameric human alpha2-macroglobulin abrogate binding of platelet-derived growth factor-BB and transforming growth factor-beta1.

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Europe PubMed Central

PubMed publication ID

20 December 2017

http://europepmc.org/abstract/MED/16641085

Limited mutations in full-length tetrameric human alpha2-macroglobulin abrogate binding of platelet-derived growth factor-BB and transforming growth factor-beta1. (English)

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Europe PubMed Central

PubMed publication ID

20 December 2017

http://europepmc.org/abstract/MED/16641085

Sanja Arandjelovic

1

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Sanja Arandjelovic

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Europe PubMed Central

PubMed publication ID

20 December 2017

author name string

Cristina L Van Sant

2

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Europe PubMed Central

PubMed publication ID

20 December 2017

http://europepmc.org/abstract/MED/16641085

Steven L Gonias

3

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Europe PubMed Central

PubMed publication ID

20 December 2017

http://europepmc.org/abstract/MED/16641085

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publication date

26 April 2006

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Europe PubMed Central

PubMed publication ID

20 December 2017

http://europepmc.org/abstract/MED/16641085

Journal of Biological Chemistry

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Europe PubMed Central

PubMed publication ID

20 December 2017

http://europepmc.org/abstract/MED/16641085

281

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Europe PubMed Central

PubMed publication ID

20 December 2017

http://europepmc.org/abstract/MED/16641085

25

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Europe PubMed Central

PubMed publication ID

20 December 2017

http://europepmc.org/abstract/MED/16641085

17061-17068

1 reference

Europe PubMed Central

PubMed publication ID

20 December 2017

http://europepmc.org/abstract/MED/16641085

The interaction of alpha 2-macroglobulin with proteinases. Characteristics and specificity of the reaction, and a hypothesis concerning its molecular mechanism

1 reference

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The electrophoretically ‘slow’ and ‘fast’ forms of the α2-macroglobulin molecule

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The role of enzyme lysyl amino groups in the reaction with alpha 2-macroglobulin

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Further characterization of the covalent linking reaction of α2-macroglobulin

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Evidence for similar conformational changes in α2-macroglobulin on reaction with primary amines or proteolytic enzymes

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Physical properties of human alpha 2-macroglobulin following reaction with methylamine and trypsin.

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The PDGF family: four gene products form five dimeric isoforms

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Specific covalent binding of platelet-derived growth factor to human plasma alpha 2-macroglobulin

1 reference

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Plasma binding proteins for platelet-derived growth factor that inhibit its binding to cell-surface receptors

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Inhibition of platelet-derived growth factor-BB-induced fibroblast proliferation by plasmin-activated alpha 2-macroglobulin is mediated via an alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein-dependent mechanism

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21 January 2018

Identical or overlapping sequences in the primary structure of human alpha(2)-macroglobulin are responsible for the binding of nerve growth factor-beta, platelet-derived growth factor-BB, and transforming growth factor-beta

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TGF-beta signal transduction

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Making sense of latent TGFbeta activation

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α2‐Macroglobulin and the α2‐Macroglobulin Receptor/LRP A Growth Regulatory Axisa

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Localization of the binding site for transforming growth factor-beta in human alpha2-macroglobulin to a 20-kDa peptide that also contains the bait region

1 reference

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21 January 2018

A 16-amino acid peptide from human alpha2-macroglobulin binds transforming growth factor-beta and platelet-derived growth factor-BB.

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21 January 2018

Growth factor-binding sequence in human alpha2-macroglobulin targets the receptor-binding site in transforming growth factor-beta

1 reference

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21 January 2018

Thiol ester role in correct folding and conformation of human alpha 2-macroglobulin. Properties of recombinant C949S variant

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21 January 2018

Alpha 2-macroglobulin bait region variants. A role for the bait region in tetramer formation

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21 January 2018

The requirement for the hydrophobic motif phosphorylation of Ypk1 in yeast differs depending on the downstream events, including endocytosis, cell growth, and resistance to a sphingolipid biosynthesis inhibitor, ISP-1.

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21 January 2018

Physical and chemical properties of human plasma β2-macroglobulin

1 reference

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21 January 2018

Binding of transforming growth factor-beta 1 to immobilized human alpha 2-macroglobulin

1 reference

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21 January 2018

Distinct binding sites in the structure of alpha 2-macroglobulin mediate the interaction with beta-amyloid peptide and growth factors

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21 January 2018

Regulation of macrophage alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein by lipopolysaccharide and interferon-gamma

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21 January 2018

Ligand binding, conformational change and plasma elimination of human, mouse and rat α-macroglobulin proteinase inhibitors

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21 January 2018

Effects of low density lipoprotein receptor-related protein-1 on the expression of platelet-derived growth factor beta-receptor in vitro

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21 January 2018

Alpha2-macroglobulin associates with beta-amyloid peptide and prevents fibril formation

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21 January 2018

Selective mutations in cloned and expressed alpha-macroglobulin receptor binding fragment alter binding to either the alpha2-macroglobulin signaling receptor or the low density lipoprotein receptor-related protein/alpha2-macroglobulin receptor

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21 January 2018

Crystal structure of the receptor-binding domain of alpha 2-macroglobulin

1 reference

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21 January 2018

Binding of transforming growth factor-beta 1 to methylamine-modified alpha 2-macroglobulin and to binary and ternary alpha 2-macroglobulin-proteinase complexes

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21 January 2018

Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction

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21 January 2018

Murine alpha-macroglobulins demonstrate divergent activities as neutralizers of transforming growth factor-beta and as inducers of nitric oxide synthesis. A possible mechanism for the endotoxin insensitivity of the alpha2-macroglobulin gene knock-ou

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Extracellular matrix-associated transforming growth factor-beta: role in cancer cell growth and invasion.

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Differential Binding and Regulation of Platelet-derived Growth Factor A and B Chain Isoforms by α2-Macroglobulin

1 reference

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Platelet‐derived growth factor

1 reference

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Critical role of asparagine 1065 of human alpha2-macroglobulin in formation and reactivity of the thiol ester

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Comparison of the esterase activities of trypsin, plasmin, and thrombin on guanidinobenzoate esters. Titration of the enzymes

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Preparation and binding of radioactively labeled porcine transforming growth factor type beta

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A thiol-ester in α2-macroglobulin cleaved during proteinase complex formation

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Identification of residues in alpha-macroglobulins important for binding to the alpha2-macroglobulin receptor/Low density lipoprotein receptor-related protein

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NMR solution structure of the receptor binding domain of human alpha(2)-macroglobulin

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Targeted inactivation of the mouse alpha 2-macroglobulin gene

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Identifiers

10.1074/JBC.M602217200

1 reference

Europe PubMed Central

PubMed publication ID

20 December 2017

http://europepmc.org/abstract/MED/16641085

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

20 December 2017

http://europepmc.org/abstract/MED/16641085

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