(Q46233590)

English

A mechanism-based population pharmacokinetic model for characterizing time-dependent pharmacokinetics of midostaurin and its metabolites in human subjects

scientific article published in January 2008

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scholarly article

1 reference

Europe PubMed Central

20 December 2017

http://europepmc.org/abstract/MED/19026036

A mechanism-based population pharmacokinetic model for characterizing time-dependent pharmacokinetics of midostaurin and its metabolites in human subjects (English)

1 reference

Europe PubMed Central

20 December 2017

http://europepmc.org/abstract/MED/19026036

human subject research project

0 references

pharmacokinetics

1 reference

based on heuristic

inferred from title

author name string

Ophelia Q P Yin

1

1 reference

Europe PubMed Central

20 December 2017

http://europepmc.org/abstract/MED/19026036

Yanfeng Wang

2

1 reference

Europe PubMed Central

20 December 2017

http://europepmc.org/abstract/MED/19026036

Horst Schran

3

1 reference

Europe PubMed Central

20 December 2017

http://europepmc.org/abstract/MED/19026036

publication date

1 January 2008

1 reference

Europe PubMed Central

20 December 2017

http://europepmc.org/abstract/MED/19026036

Clinical Pharmacokinetics

1 reference

Europe PubMed Central

20 December 2017

http://europepmc.org/abstract/MED/19026036

47

1 reference

Europe PubMed Central

20 December 2017

http://europepmc.org/abstract/MED/19026036

12

1 reference

Europe PubMed Central

20 December 2017

http://europepmc.org/abstract/MED/19026036

807-816

1 reference

Europe PubMed Central

20 December 2017

http://europepmc.org/abstract/MED/19026036

https://scigraph.springernature.com/pub.10.2165/0003088-200847120-00005

0 references

Dramatic inhibition of retinal and choroidal neovascularization by oral administration of a kinase inhibitor

1 reference

https://api.crossref.org/works/10.2165%2F0003088-200847120-00005

21 January 2018

Different susceptibility of protein kinases to staurosporine inhibition. Kinetic studies and molecular bases for the resistance of protein kinase CK2

1 reference

https://pubmed.ncbi.nlm.nih.gov/19026036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Population pharmacokinetics of lamotrigine monotherapy in patients with epilepsy: retrospective analysis of routine monitoring data

1 reference

https://pubmed.ncbi.nlm.nih.gov/19026036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The kinase inhibitor PKC412 suppresses epiretinal membrane formation and retinal detachment in mice with proliferative retinopathies

1 reference

https://pubmed.ncbi.nlm.nih.gov/19026036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Upregulation of the vascular endothelial growth factor/vascular endothelial growth factor receptor system in experimental background diabetic retinopathy of the rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19026036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction

1 reference

https://pubmed.ncbi.nlm.nih.gov/19026036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacodynamic modeling of time-dependent transduction systems

1 reference

https://pubmed.ncbi.nlm.nih.gov/19026036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism-based PK/PD model for the lymphocytopenia induced by endogenous and exogenous corticosteroids

1 reference

https://pubmed.ncbi.nlm.nih.gov/19026036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential inhibition of the epidermal growth factor-, platelet-derived growth factor-, and protein kinase C-mediated signal transduction pathways by the staurosporine derivative CGP 41251

1 reference

https://pubmed.ncbi.nlm.nih.gov/19026036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The kinetics of the auto-induction of ifosfamide metabolism during continuous infusion

1 reference

https://pubmed.ncbi.nlm.nih.gov/19026036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Patients with acute myeloid leukemia and an activating mutation in FLT3 respond to a small-molecule FLT3 tyrosine kinase inhibitor, PKC412.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19026036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Retrospective analysis of artemisinin pharmacokinetics: application of a semiphysiological autoinduction model

1 reference

https://pubmed.ncbi.nlm.nih.gov/19026036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions

1 reference

https://pubmed.ncbi.nlm.nih.gov/19026036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A mechanism-based pharmacokinetic-enzyme model for cyclophosphamide autoinduction in breast cancer patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/19026036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduction of diabetic macular edema by oral administration of the kinase inhibitor PKC412.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19026036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Vascular endothelial growth factor and diabetic retinopathy: pathophysiological mechanisms and treatment perspectives.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19026036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A derivative of staurosporine (CGP 41 251) shows selectivity for protein kinase C inhibition and in vitro anti-proliferative as well as in vivo anti-tumor activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/19026036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PKC412--a protein kinase inhibitor with a broad therapeutic potential

1 reference

https://pubmed.ncbi.nlm.nih.gov/19026036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evaluating pharmacokinetic/pharmacodynamic models using the posterior predictive check

1 reference

https://pubmed.ncbi.nlm.nih.gov/19026036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kinetics of a carbamazepine-ethosuximide interaction

1 reference

https://pubmed.ncbi.nlm.nih.gov/19026036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Time-dependent pharmacokinetics of high dose thiopental infusion in intensive care patients.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19026036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Integrated Population Pharmacokinetic Model of both cyclophosphamide and thiotepa suggesting a mutual drug-drug interaction

1 reference

https://pubmed.ncbi.nlm.nih.gov/19026036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Time course of enzyme induction in humans: effect of pentobarbital on nortriptyline metabolism.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19026036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Population pharmacokinetics of methadone in opiate users: characterization of time-dependent changes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19026036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase I and pharmacokinetic study of PKC412, an inhibitor of protein kinase C.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19026036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.2165/0003088-200847120-00005

1 reference

Europe PubMed Central

20 December 2017

http://europepmc.org/abstract/MED/19026036

Dimensions Publication ID

0 references

1 reference

Europe PubMed Central

20 December 2017

http://europepmc.org/abstract/MED/19026036

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