(Q46260461)

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Acute clozapine exposure in vivo induces lipid accumulation and marked sequential changes in the expression of SREBP, PPAR, and LXR target genes in rat liver

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scholarly article

1 reference

Europe PubMed Central

20 December 2017

http://europepmc.org/abstract/MED/18989661

Acute clozapine exposure in vivo induces lipid accumulation and marked sequential changes in the expression of SREBP, PPAR, and LXR target genes in rat liver (English)

1 reference

Europe PubMed Central

20 December 2017

http://europepmc.org/abstract/MED/18989661

Oddrun Gudbrandsen

7

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Europe PubMed Central

20 December 2017

http://europepmc.org/abstract/MED/18989661

2

object named as

Audun O Vik-Mo

1 reference

Europe PubMed Central

20 December 2017

13

object named as

Vidar M Steen

1 reference

Europe PubMed Central

20 December 2017

http://europepmc.org/abstract/MED/18989661

5

object named as

Kjetil Berge

1 reference

Europe PubMed Central

20 December 2017

http://europepmc.org/abstract/MED/18989661

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object named as

Sverre Mørk

1 reference

Europe PubMed Central

20 December 2017

http://europepmc.org/abstract/MED/18989661

author name string

Johan Fernø

1

1 reference

Europe PubMed Central

20 December 2017

http://europepmc.org/abstract/MED/18989661

Goran Jassim

3

1 reference

Europe PubMed Central

20 December 2017

http://europepmc.org/abstract/MED/18989661

Bjarte Håvik

4

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Europe PubMed Central

20 December 2017

http://europepmc.org/abstract/MED/18989661

Silje Skrede

6

1 reference

Europe PubMed Central

20 December 2017

http://europepmc.org/abstract/MED/18989661

Jo Waage

8

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Europe PubMed Central

20 December 2017

http://europepmc.org/abstract/MED/18989661

Niclas Lunder

9

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Europe PubMed Central

20 December 2017

http://europepmc.org/abstract/MED/18989661

Rolf K Berge

11

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Europe PubMed Central

20 December 2017

http://europepmc.org/abstract/MED/18989661

Hugo A Jørgensen

12

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Europe PubMed Central

20 December 2017

http://europepmc.org/abstract/MED/18989661

publication date

30 October 2008

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Europe PubMed Central

20 December 2017

http://europepmc.org/abstract/MED/18989661

number of pages

12

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Psychopharmacology

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Europe PubMed Central

20 December 2017

http://europepmc.org/abstract/MED/18989661

203

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http://europepmc.org/abstract/MED/18989661

1

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http://europepmc.org/abstract/MED/18989661

73-84

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20 December 2017

http://europepmc.org/abstract/MED/18989661

https://scigraph.springernature.com/pub.10.1007/s00213-008-1370-x

0 references

SREBP-1c transcription factor and lipid homeostasis: clinical perspective

1 reference

https://api.crossref.org/works/10.1007%2FS00213-008-1370-X

21 January 2018

SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

1 reference

https://api.crossref.org/works/10.1007%2FS00213-008-1370-X

21 January 2018

Clozapine for the treatment-resistant schizophrenic. A double-blind comparison with chlorpromazine

1 reference

https://api.crossref.org/works/10.1007%2FS00213-008-1370-X

21 January 2018

Comprehensive analysis of PPARalpha-dependent regulation of hepatic lipid metabolism by expression profiling

1 reference

https://api.crossref.org/works/10.1007%2FS00213-008-1370-X

21 January 2018

Rosiglitazone induction of Insig-1 in white adipose tissue reveals a novel interplay of peroxisome proliferator-activated receptor gamma and sterol regulatory element-binding protein in the regulation of adipogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diminished suicidal and aggressive behavior, high plasma norepinephrine levels, and serum triglyceride levels in chronic neuroleptic-resistant schizophrenic patients maintained on clozapine.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Elevated serum triglycerides with clozapine resolved with risperidone in four patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A new transgenic rat model of hepatic steatosis and the metabolic syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. II. LXRs suppress lipid degradation gene promoters through inhibition of PPAR signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics of clozapine and risperidone: a review of recent literature

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Olanzapine induces SREBP-1-related adipogenesis in 3T3-L1 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alterations of lipid metabolism and gene expression in rat adipocytes during chronic olanzapine treatment

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The 5-HT2C receptor and antipsychoticinduced weight gain - mechanisms and genetics.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cross-talk between fatty acid and cholesterol metabolism mediated by liver X receptor-alpha.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SREBF-1 gene polymorphisms are associated with obesity and type 2 diabetes in French obese and diabetic cohorts

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Atypical antipsychotic drugs directly impair insulin action in adipocytes: effects on glucose transport, lipogenesis, and antilipolysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Development and validation of real-time quantitative reverse transcriptase-polymerase chain reaction for monitoring gene expression in cardiac myocytes in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tissue-specific expression and cholesterol regulation of acylcoenzyme A:cholesterol acyltransferase (ACAT) in mice. Molecular cloning of mouse ACAT cDNA, chromosomal localization, and regulation of ACAT in vivo and in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Retinoid x receptor heterodimers in the metabolic syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lipid accumulation in the livers of chlorpromazine-treated rats does not induce peroxisome proliferation

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clozapine-associated elevation in serum triglycerides

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A model for antipsychotic-induced obesity in the male rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

"New" hepatic fat activates PPARalpha to maintain glucose, lipid, and cholesterol homeostasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prevalence of the metabolic syndrome among patients receiving clozapine

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fatty acid regulation of hepatic gene transcription.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. I. PPARs suppress sterol regulatory element binding protein-1c promoter through inhibition of L

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clozapine-induced agranulocytosis. Incidence and risk factors in the United States

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

H1-histamine receptor affinity predicts short-term weight gain for typical and atypical antipsychotic drugs.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Drug-induced activation of SREBP-controlled lipogenic gene expression in CNS-related cell lines: marked differences between various antipsychotic drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic treatment with antipsychotics in rats as a model for antipsychotic-induced weight gain in human

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased expression of lipid biosynthesis genes in peripheral blood cells of olanzapine-treated patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolomic mapping of atypical antipsychotic effects in schizophrenia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clozapine, diabetes mellitus, weight gain, and lipid abnormalities: A five-year naturalistic study

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

From the Cover: Antipsychotic drug-induced weight gain mediated by histamine H1 receptor-linked activation of hypothalamic AMP-kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic dissection of atypical antipsychotic-induced weight gain: novel preliminary data on the pharmacogenetic puzzle

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolic syndrome X: a review

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clozapine: weight gain in a pair of monozygotic twins concordant for schizophrenia and mild mental retardation

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tissue concentrations of clozapine and its metabolites in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The AGNP-TDM expert group consensus guidelines: therapeutic drug monitoring in psychiatry

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antipsychotic-induced weight gain: a comprehensive research synthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Treatments for schizophrenia: a critical review of pharmacology and mechanisms of action of antipsychotic drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clozapine and weight gain

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Association between the insulin-induced gene 2 (INSIG2) and weight gain in a German sample of antipsychotic-treated schizophrenic patients: perturbation of SREBP-controlled lipogenesis in drug-related metabolic adverse effects?

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Magic shotguns versus magic bullets: selectively non-selective drugs for mood disorders and schizophrenia

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SREBP activation by antipsychotic- and antidepressant-drugs in cultured human liver cells: relevance for metabolic side-effects?

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Serum triglyceride levels in patients treated with clozapine

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antipsychotic drugs activate SREBP-regulated expression of lipid biosynthetic genes in cultured human glioma cells: a novel mechanism of action?

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The emerging role of glutamate in the pathophysiology and treatment of schizophrenia

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acyl-coenzyme A:cholesterol acyltransferase

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Treatment-resistant schizophrenic patients respond to clozapine after olanzapine non-response.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00213-008-1370-X

1 reference

Europe PubMed Central

20 December 2017

http://europepmc.org/abstract/MED/18989661

1 reference

Europe PubMed Central

20 December 2017

http://europepmc.org/abstract/MED/18989661

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