(Q46384302)

21 December 2017

title

Aggregation and chemical modification of monoclonal antibodies under upstream processing conditions (English)

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21 December 2017

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Stefan Dengl

1

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21 December 2017

Marc Wehmer

2

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21 December 2017

Friederike Hesse

3

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21 December 2017

Florian Lipsmeier

4

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21 December 2017

Oliver Popp

5

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21 December 2017

Kurt Lang

6

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21 December 2017

language of work or name

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16 January 2013

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21 December 2017

published in

Pharmaceutical Research

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21 December 2017

volume

30

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21 December 2017

issue

5

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21 December 2017

page(s)

1380-1399

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21 December 2017

Potent antibody therapeutics by design

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21 January 2018

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Protein aggregation and bioprocessing

21 January 2018

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Aggregates in monoclonal antibody manufacturing processes

21 January 2018

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Induction of protein aggregation in an early secretory compartment by elevation of expression level

21 January 2018

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Protein aggregation during overexpression limited by peptide extensions with large net negative charge.

21 January 2018

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Influence of osmolarity and pH increase to achieve a reduction of monoclonal antibodies aggregates in a production process

21 January 2018

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Antibody structure, instability, and formulation

21 January 2018

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Effects of protein aggregates: an immunologic perspective

21 January 2018

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High cell density cultivation of Escherichia coli K4 in a microfiltration bioreactor: a step towards improvement of chondroitin precursor production

21 January 2018

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A study in glycation of a therapeutic recombinant humanized monoclonal antibody: where it is, how it got there, and how it affects charge-based behavior

21 January 2018

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Chemical instability of protein pharmaceuticals: Mechanisms of oxidation and strategies for stabilization

21 January 2018

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Heterogeneity of monoclonal antibodies

21 January 2018

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CHO cells in biotechnology for production of recombinant proteins: current state and further potential

21 January 2018

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An XBP-1 dependent bottle-neck in production of IgG subtype antibodies in chemically defined serum-free Chinese hamster ovary (CHO) fed-batch processes

21 January 2018

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How to measure and predict the molar absorption coefficient of a protein

21 January 2018

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Protein denaturation by combined effect of shear and air-liquid interface

21 January 2018

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Effects of shear on proteins in solution

21 January 2018

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Relative stabilities of IgG1 and IgG4 Fab domains: influence of the light-heavy interchain disulfide bond architecture

21 January 2018

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Contribution of variable domains to the stability of humanized IgG1 monoclonal antibodies.

21 January 2018

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Cell culture processes for monoclonal antibody production

21 January 2018

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Effects of Tween 20 and Tween 80 on the stability of Albutropin during agitation

21 January 2018

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Prevention of human granulocyte colony-stimulating factor protein aggregation in recombinant Pichia pastoris fed-batch fermentation using additives

21 January 2018

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21 January 2018

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Effect of surfactant pluronic F-68 on CHO cell growth, metabolism, production, and glycosylation of human recombinant IFN-γ in mild operating conditions.

21 January 2018

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The fate of Pluronic F-68 in chondrocytes and CHO cells

21 January 2018

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Heterogeneity of monoclonal antibodies revealed by charge-sensitive methods

21 January 2018

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Influence of pH, buffer species, and storage temperature on physicochemical stability of a humanized monoclonal antibody LA298.

21 January 2018

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The thermal stability of immunoglobulin: unfolding and aggregation of a multi-domain protein

21 January 2018

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Protein aggregation--pathways and influencing factors

21 January 2018

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High-throughput measurement, correlation analysis, and machine-learning predictions for pH and thermal stabilities of Pfizer-generated antibodies

21 January 2018

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Instability, stabilization, and formulation of liquid protein pharmaceuticals

21 January 2018

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Stability of protein pharmaceuticals: an update

21 January 2018

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Elucidation of degradants in acidic peak of cation exchange chromatography in an IgG1 monoclonal antibody formed on long-term storage in a liquid formulation

21 January 2018

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Changes in the quality of antibodies produced by Chinese hamster ovary cells during the death phase of cell culture

21 January 2018

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In vivo deamidation characterization of monoclonal antibody by LC/MS/MS.

21 January 2018

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21 January 2018

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Engineering Aggregation Resistance in IgG by Two Independent Mechanisms: Lessons from Comparison of Pichia pastoris and Mammalian Cell Expression

21 January 2018

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'Knobs-into-holes' engineering of antibody CH3 domains for heavy chain heterodimerization

21 January 2018

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12 December 2020

Aggregation stability of a monoclonal antibody during downstream processing

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12 December 2020

Culture temperature modulates aggregation of recombinant antibody in cho cells

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12 December 2020

Shaken, not stirred: mechanical stress testing of an IgG1 antibody

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12 December 2020

Induction and analysis of aggregates in a liquid IgG1-antibody formulation

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12 December 2020

Identification of multiple sources of charge heterogeneity in a recombinant antibody.

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12 December 2020

Surfactant-protein interactions

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12 December 2020

Prevention of stirring-induced microparticle formation in monoclonal antibody solutions

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12 December 2020

Determining antibody stability: creation of solid-liquid interfacial effects within a high shear environment.

1 reference

12 December 2020

Shear sensitivity of animal cells from a culture-medium perspective

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12 December 2020

Opposite effects of polyols on antibody aggregation: thermal versus mechanical stresses

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12 December 2020

On the adsorption of proteins on solid surfaces, a common but very complicated phenomenon.

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12 December 2020

Tween protects recombinant human growth hormone against agitation-induced damage via hydrophobic interactions

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12 December 2020

Post-production protein stability: trouble beyond the cell factory.

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12 December 2020

Chemical pathways of peptide degradation. II. Kinetics of deamidation of an asparaginyl residue in a model hexapeptide

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12 December 2020

Deamidation, isomerization, and racemization at asparaginyl and aspartyl residues in peptides. Succinimide-linked reactions that contribute to protein degradation

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12 December 2020

10.1007/S11095-013-0977-8

Identifiers

DOI

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21 December 2017

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21 December 2017