(Q46402658)

7 June 2018

title

PARK2 Depletion Connects Energy and Oxidative Stress to PI3K/Akt Activation via PTEN S-Nitrosylation (English)

1 reference

7 June 2018

author

Adamo Valle

6

1 reference

http://europepmc.org/abstract/MED/28306514

21 December 2017

Dimitrios Anastasiou

object named as

Dimitrios Anastasiou

12

0 references

George Poulogiannis

object named as

George Poulogiannis

15

0 references

author name string

Amit Gupta

1

1 reference

7 June 2018

Sara Anjomani-Virmouni

2

1 reference

7 June 2018

Nikos Koundouros

3

1 reference

7 June 2018

Maria Dimitriadi

4

1 reference

7 June 2018

Rayman Choo-Wing

5

1 reference

7 June 2018

Yuxiang Zheng

7

1 reference

7 June 2018

Yu-Hsin Chiu

8

1 reference

7 June 2018

Sameer Agnihotri

9

1 reference

7 June 2018

Gelareh Zadeh

10

1 reference

7 June 2018

John M Asara

11

1 reference

7 June 2018

Mark J Arends

13

1 reference

7 June 2018

Lewis C Cantley

14

1 reference

7 June 2018

publication date

1 March 2017

1 reference

7 June 2018

published in

Molecular Cell

1 reference

7 June 2018

volume

65

1 reference

7 June 2018

issue

6

1 reference

7 June 2018

page(s)

999-1013.e7

1 reference

7 June 2018

Cross-validation of survival associated biomarkers in gastric cancer using transcriptomic data of 1,065 patients

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1 reference

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8 June 2018

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PIK3CA(H1047R) Accelerates and Enhances KRAS(G12D)-Driven Lung Tumorigenesis

8 June 2018

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Mitochondrial Quality Control via the PGC1α-TFEB Signaling Pathway Is Compromised by Parkin Q311X Mutation But Independently Restored by Rapamycin

8 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5426642

Parkin loss leads to PARIS-dependent declines in mitochondrial mass and respiration

8 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5426642

Genomic and Functional Analysis of the E3 Ligase PARK2 in Glioma

8 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5426642

Glutathione: new roles in redox signaling for an old antioxidant

8 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5426642

Pan-cancer genetic analysis identifies PARK2 as a master regulator of G1/S cyclins

8 June 2018

1 reference

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Activation of the PI3K/mTOR/AKT pathway and survival in solid tumors: systematic review and meta-analysis

8 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5426642

Structural basis of AMPK regulation by small molecule activators

8 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5426642

The ubiquitin ligase parkin mediates resistance to intracellular pathogens

8 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5426642

Nitric oxide-based protein modification: formation and site-specificity of protein S-nitrosylation

8 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5426642

Mitochondrial quality control turns out to be the principal suspect in parkin and PINK1-related autosomal recessive Parkinson's disease

8 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5426642

A positive/negative ion-switching, targeted mass spectrometry-based metabolomics platform for bodily fluids, cells, and fresh and fixed tissue

8 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5426642

The functions and regulation of the PTEN tumour suppressor

8 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5426642

The chemical biology of S-nitrosothiols

8 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5426642

Parkin pathway activation mitigates glioma cell proliferation and predicts patient survival

8 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5426642

Alkylpurine-DNA-N-glycosylase confers resistance to temozolomide in xenograft models of glioblastoma multiforme and is associated with poor survival in patients

8 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5426642

Parkin, a p53 target gene, mediates the role of p53 in glucose metabolism and the Warburg effect

8 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5426642

On-off system for PI3-kinase-Akt signaling through S-nitrosylation of phosphatase with sequence homology to tensin (PTEN)

8 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5426642

Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent manner

8 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5426642

NO signaling and S-nitrosylation regulate PTEN inhibition in neurodegeneration

8 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5426642

PARK2 deletions occur frequently in sporadic colorectal cancer and accelerate adenoma development in Apc mutant mice.

8 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5426642

Parkin enhances the expression of cyclin-dependent kinase 6 and negatively regulates the proliferation of breast cancer cells

8 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5426642

The role of parkin in familial and sporadic Parkinson's disease

8 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5426642

Somatic mutations of the Parkinson's disease-associated gene PARK2 in glioblastoma and other human malignancies

8 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5426642

mTOR and cancer: many loops in one pathway.

8 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5426642

Detecting purely epistatic multi-locus interactions by an omnibus permutation test on ensembles of two-locus analyses

8 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5426642

Parkin promotes intracellular Abeta1-42 clearance

8 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5426642

Autism genome-wide copy number variation reveals ubiquitin and neuronal genes

8 June 2018

1 reference

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The PTEN-PI3K pathway: of feedbacks and cross-talks

8 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5426642

PI3K pathway alterations in cancer: variations on a theme

8 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5426642

Redox regulation of cell survival

8 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5426642

Recurrent gross mutations of the PTEN tumor suppressor gene in breast cancers with deficient DSB repair.

8 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5426642

AKT/PKB signaling: navigating downstream

8 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5426642

Mitochondrial-targeted active Akt protects SH-SY5Y neuroblastoma cells from staurosporine-induced apoptotic cell death

8 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5426642

A regulated interaction with the UIM protein Eps15 implicates parkin in EGF receptor trafficking and PI(3)K-Akt signalling

8 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5426642

PTEN gene targeting reveals a radiation-induced size checkpoint in human cancer cells

8 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5426642

Alterations of the tumor suppressor gene Parkin in non-small cell lung cancer

8 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5426642

Parkin gene alterations in hepatocellular carcinoma

8 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5426642

Susceptibility to leprosy is associated with PARK2 and PACRG.

8 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5426642

Pten dose dictates cancer progression in the prostate

8 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5426642

Down-regulation of the tumor suppressor PTEN by the tumor necrosis factor-alpha/nuclear factor-kappaB (NF-kappaB)-inducing kinase/NF-kappaB pathway is linked to a default IkappaB-alpha autoregulatory loop.

8 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5426642

Parkin gene inactivation alters behaviour and dopamine neurotransmission in the mouse

8 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5426642

The role of HIF-1 alpha in transcriptional regulation of the proximal tubular epithelial cell response to hypoxia

8 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5426642

Growth-suppressive effects of BPOZ and EGR2, two genes involved in the PTEN signaling pathway.

8 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5426642

Association between early-onset Parkinson's disease and mutations in the parkin gene

8 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5426642

Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation

8 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5426642

Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems

8 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5426642

Pten is essential for embryonic development and tumour suppression

8 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5426642

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

8 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5426642

When metabolism rules perfusion: AMPK-mediated endothelial nitric oxide synthase activation.

8 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5426642

Parkin as a tumor suppressor gene for hepatocellular carcinoma

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5426642

Parkin mutations are frequent in patients with isolated early-onset parkinsonism.

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5426642

Differential risks of cancer types in people with Parkinson's disease: a national record-linkage study

15 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28306514

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The importance of gene dosage studies: mutational analysis of the parkin gene in early-onset parkinsonism

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28306514

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.MOLCEL.2017.02.019

1 reference

7 June 2018

PMCID

5426642

1 reference

7 June 2018

PubMed ID

28306514

1 reference

7 June 2018