(Q46492112)

22 December 2017

title

Phosphothreonine-212 of Alzheimer abnormally hyperphosphorylated tau is a preferred substrate of protein phosphatase-1. (English)

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22 December 2017

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2

Inge Grundke-Iqbal

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22 December 2017

Abdur Rahman

1

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22 December 2017

Khalid Iqbal

series ordinal

3

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22 December 2017

publication date

1 February 2005

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22 December 2017

published in

Neurochemical Research

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22 December 2017

volume

30

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22 December 2017

issue

2

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22 December 2017

page(s)

277-287

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22 December 2017

https://scigraph.springernature.com/pub.10.1007/s11064-005-2483-9

exact match

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cites work

New phosphorylation sites identified in hyperphosphorylated tau (paired helical filament-tau) from Alzheimer's disease brain using nanoelectrospray mass spectrometry

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12 December 2020

Reduced protein phosphatase 2A activity induces hyperphosphorylation and altered compartmentalization of tau in transgenic mice.

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12 December 2020

Dephosphorylation of Alzheimer's disease abnormally phosphorylated tau by protein phosphatase-2A.

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12 December 2020

Indexing-based differential display--studies on post-mortem Alzheimer's brains.

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12 December 2020

Phosphorylation of microtubule-associated protein tau is regulated by protein phosphatase 2A in mammalian brain. Implications for neurofibrillary degeneration in Alzheimer's disease.

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12 December 2020

Phosphorylation affects the ability of tau protein to promote microtubule assembly.

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12 December 2020

Dephosphorylation and deactivation of Ca2+/calmodulin-dependent protein kinase II in betaTC3-cells is mediated by Mg2+- and okadaic-acid-sensitive protein phosphatases

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12 December 2020

Promotion of hyperphosphorylation by frontotemporal dementia tau mutations

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12 December 2020

Inhibition of PP-2A upregulates CaMKII in rat forebrain and induces hyperphosphorylation of tau at Ser 262/356.

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12 December 2020

Dephosphorylation of Alzheimer paired helical filaments by protein phosphatase-2A and -2B.

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12 December 2020

Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology

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12 December 2020

Alzheimer's disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules.

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12 December 2020

Role of serine/threonine protein phosphatase in Alzheimer's disease

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12 December 2020

Abnormal phosphorylation of tau and the mechanism of Alzheimer neurofibrillary degeneration: sequestration of microtubule-associated proteins 1 and 2 and the disassembly of microtubules by the abnormal tau

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12 December 2020

Subcellular distribution of protein phosphatases and abnormally phosphorylated tau in the temporal cortex from Alzheimer's disease and control brains.

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12 December 2020

Multiple forms of phosphatase from human brain: isolation and partial characterization of affi-gel blue binding phosphatases.

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12 December 2020

Okadaic-acid-induced inhibition of protein phosphatase 2A produces activation of mitogen-activated protein kinases ERK1/2, MEK1/2, and p70 S6, similar to that in Alzheimer's disease

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12 December 2020

Phosphoprotein phosphatase activities in Alzheimer disease brain

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12 December 2020

Alzheimer's disease abnormally phosphorylated tau is dephosphorylated by protein phosphatase-2B (calcineurin).

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12 December 2020

Microtubule-associated protein tau. Abnormal phosphorylation of a non-paired helical filament pool in Alzheimer disease.

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12 December 2020

Restoration of biological activity of Alzheimer abnormally phosphorylated tau by dephosphorylation with protein phosphatase-2A, -2B and -1.

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12 December 2020

Abnormal phosphorylation of tau precedes ubiquitination in neurofibrillary pathology of Alzheimer disease

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12 December 2020

Role of protein phosphatase-2A and -1 in the regulation of GSK-3, cdk5 and cdc2 and the phosphorylation of tau in rat forebrain.

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12 December 2020

Phosphatase activity toward abnormally phosphorylated tau: decrease in Alzheimer disease brain.

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12 December 2020

Tau protein isoforms, phosphorylation and role in neurodegenerative disorders11These authors contributed equally to this work

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12 December 2020

Localization of protein Ser/Thr phosphatase 5 in rat brain.

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12 December 2020

The regulation of phosphorylation of tau in SY5Y neuroblastoma cells: the role of protein phosphatases.

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12 December 2020

Defective brain microtubule assembly in Alzheimer's disease

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12 December 2020

Activation of the ERK and JNK signaling pathways caused by neuron-specific inhibition of PP2A in transgenic mice

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12 December 2020

Dephosphorylation of microtubule-associated protein tau by protein phosphatase 5

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12 December 2020

Up-regulation of calcineurin Abeta mRNA in the Alzheimer's disease brain: assessment by cDNA microarray

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12 December 2020

Dephosphorylation of microtubule-associated protein tau by protein phosphatase-1 and -2C and its implication in Alzheimer disease.

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12 December 2020

Role of abnormally phosphorylated tau in the breakdown of microtubules in Alzheimer disease

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12 December 2020

Hyperphosphorylation induces self-assembly of tau into tangles of paired helical filaments/straight filaments

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12 December 2020

Microtubule-associated protein tau. A component of Alzheimer paired helical filaments.

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12 December 2020

Impairment of phosphatase 2A contributes to the prolonged MAP kinase phosphorylation in Alzheimer's disease fibroblasts

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12 December 2020

Dephosphorylation of tau by protein phosphatase 5: impairment in Alzheimer's disease

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12 December 2020

Interaction of tau isoforms with Alzheimer's disease abnormally hyperphosphorylated tau and in vitro phosphorylation into the disease-like protein

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12 December 2020

Multiple forms of phosphatase from human brain: isolation and partial characterization of affi-gel blue nonbinding phosphatase activities.

1 reference

12 December 2020

Occurrence of neuropil threads in the senile human brain and in Alzheimer's disease: a third location of paired helical filaments outside of neurofibrillary tangles and neuritic plaques.

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12 December 2020

Selective changes of calcineurin (protein phosphatase 2B) activity in Alzheimer's disease cerebral cortex

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12 December 2020

10.1007/S11064-005-2483-9

Identifiers

DOI

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22 December 2017

PubMed ID

15895832

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22 December 2017