(Q35791980)

English

Okadaic-acid-induced inhibition of protein phosphatase 2A produces activation of mitogen-activated protein kinases ERK1/2, MEK1/2, and p70 S6, similar to that in Alzheimer's disease

scientific article published on September 2003

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

Okadaic-acid-induced inhibition of protein phosphatase 2A produces activation of mitogen-activated protein kinases ERK1/2, MEK1/2, and p70 S6, similar to that in Alzheimer's disease (English)

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

Alzheimer's disease

0 references

4

object named as

Bengt Winblad

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

Inge Grundke-Iqbal

6

object named as

Inge Grundke-Iqbal

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

1

object named as

Jin-Jing Pei

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

2

object named as

Cheng-Xin Gong

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

Richard F. Cowburn

5

object named as

Richard F Cowburn

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

7

object named as

Khalid Iqbal

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

author name string

Wen-Lin An

3

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

language of work or name

0 references

publication date

1 September 2003

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

The American Journal of Pathology

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Europe PubMed Central

PubMed publication ID

10 August 2017

163

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

3

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

845-858

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

Activation of the ERK and JNK signaling pathways caused by neuron-specific inhibition of PP2A in transgenic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1868262

12 July 2018

Pharmacological targets to inhibit Alzheimer neurofibrillary degeneration.

1 reference

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12 July 2018

Memory mechanisms: the yin and yang of protein phosphorylation

1 reference

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12 July 2018

Phosphorylated map kinase (ERK1, ERK2) expression is associated with early tau deposition in neurones and glial cells, but not with increased nuclear DNA vulnerability and cell death, in Alzheimer disease, Pick's disease, progressive supranuclear pa

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1868262

12 July 2018

Signal transduction pathways involved in phosphorylation and activation of p70S6K following exposure to UVA irradiation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1868262

12 July 2018

PP2A mRNA expression is quantitatively decreased in Alzheimer's disease hippocampus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1868262

12 July 2018

Mammalian MAP kinase signalling cascades

1 reference

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12 July 2018

Inhibition of PP-2A upregulates CaMKII in rat forebrain and induces hyperphosphorylation of tau at Ser 262/356.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1868262

12 July 2018

Nuclear export of MAP kinase (ERK) involves a MAP kinase kinase (MEK)-dependent active transport mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1868262

12 July 2018

Protein phosphatase 2A suppresses MAP kinase signalling and ectopic protein expression

1 reference

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12 July 2018

Identification of a novel inhibitor of mitogen-activated protein kinase kinase

1 reference

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12 July 2018

Protein phosphatases and the regulation of MAP kinase activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1868262

12 July 2018

Translation control: connecting mitogens and the ribosome

1 reference

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12 July 2018

Phosphorylation and activation of p70s6k by PDK1

1 reference

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Using structure to define the function of phosphoinositide 3-kinase family members

1 reference

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12 July 2018

Phosphoprotein phosphatase activities in Alzheimer disease brain

1 reference

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12 July 2018

Growth factors induce nuclear translocation of MAP kinases (p42mapk and p44mapk) but not of their activator MAP kinase kinase (p45mapkk) in fibroblasts

1 reference

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12 July 2018

Dephosphorylation of Alzheimer's disease abnormally phosphorylated tau by protein phosphatase-2A.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1868262

12 July 2018

Alzheimer's disease-like phosphorylation of the microtubule-associated protein tau by glycogen synthase kinase-3 in transfected mammalian cells.

1 reference

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12 July 2018

p44mpk MAP kinase induces Alzheimer type alterations in tau function and in primary hippocampal neurons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1868262

12 July 2018

Phosphatase activity toward abnormally phosphorylated tau: decrease in Alzheimer disease brain.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1868262

12 July 2018

A sequence of cytoskeleton changes related to the formation of neurofibrillary tangles and neuropil threads

1 reference

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12 July 2018

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1 reference

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12 July 2018

The subunit structure of rabbit-skeletal-muscle phosphorylase kinase, and the molecular basis of its activation reactions

1 reference

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12 July 2018

Microtubule-associated polypeptides tau are altered in Alzheimer paired helical filaments

1 reference

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12 July 2018

Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology

1 reference

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12 July 2018

Microtubule-associated protein tau. A component of Alzheimer paired helical filaments

1 reference

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Defective brain microtubule assembly in Alzheimer's disease

1 reference

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S6 kinase in quiescent Swiss mouse 3T3 cells is activated by phosphorylation in response to serum treatment

1 reference

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12 July 2018

Protein phosphatase inhibitor-1 and inhibitor-2 from rabbit skeletal muscle

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1868262

12 July 2018

Protein phosphatase 2A inactivates the mitogen-stimulated S6 kinase from Swiss mouse 3T3 cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1868262

12 July 2018

Identification and localization of a tau peptide to paired helical filaments of Alzheimer disease

1 reference

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12 July 2018

ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF

1 reference

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12 July 2018

Neuropathological stageing of Alzheimer-related changes

1 reference

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12 July 2018

Nuclear localization and regulation of erk- and rsk-encoded protein kinases

1 reference

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12 July 2018

Mitogen activated protein (MAP) kinase transforms tau protein into an Alzheimer-like state

1 reference

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12 July 2018

p42 MAP kinase phosphorylation sites in microtubule-associated protein tau are dephosphorylated by protein phosphatase 2A1. Implications for Alzheimer's disease [corrected]

1 reference

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12 July 2018

Implication of brain cdc2 and MAP2 kinases in the phosphorylation of tau protein in Alzheimer's disease

1 reference

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1 reference

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12 July 2018

Up-regulation of mitogen-activated protein kinases ERK1/2 and MEK1/2 is associated with the progression of neurofibrillary degeneration in Alzheimer's disease

1 reference

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Localization of active forms of C-jun kinase (JNK) and p38 kinase in Alzheimer's disease brains at different stages of neurofibrillary degeneration.

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Activation of MKK6, an upstream activator of p38, in Alzheimer's disease.

1 reference

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25 September 2018

Differential activation of neuronal ERK, JNK/SAPK and p38 in Alzheimer disease: the 'two hit' hypothesis.

1 reference

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25 September 2018

Activation and redistribution of c-jun N-terminal kinase/stress activated protein kinase in degenerating neurons in Alzheimer's disease.

1 reference

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25 September 2018

Role of protein phosphatase-2A and -1 in the regulation of GSK-3, cdk5 and cdc2 and the phosphorylation of tau in rat forebrain.

1 reference

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25 September 2018

Phosphorylation of microtubule-associated protein tau is regulated by protein phosphatase 2A in mammalian brain. Implications for neurofibrillary degeneration in Alzheimer's disease.

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Characterization of an activated ribosomal S6 kinase variant from maturing sea star oocytes: association with phosphatase 2A and substrate specificity.

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p38 kinase is activated in the Alzheimer's disease brain

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Identification of kinase-phosphatase signaling modules composed of p70 S6 kinase-protein phosphatase 2A (PP2A) and p21-activated kinase-PP2A.

1 reference

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Ser-262 in human recombinant tau protein is a markedly more favorable site for phosphorylation by CaMKII than PKA or PhK.

1 reference

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Regulation of the p70 S6 kinase by phosphorylation in vivo. Analysis using site-specific anti-phosphopeptide antibodies

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The regulation of phosphorylation of tau in SY5Y neuroblastoma cells: the role of protein phosphatases

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1 reference

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Cytoplasmic localization of mitogen-activated protein kinase kinase directed by its NH2-terminal, leucine-rich short amino acid sequence, which acts as a nuclear export signal

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1 reference

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Expression of protein phosphatases (PP-1, PP-2A, PP-2B and PTP-1B) and protein kinases (MAP kinase and P34cdc2) in the hippocampus of patients with Alzheimer disease and normal aged individuals.

1 reference

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Stimulation of MAP kinase by v-raf transformation of fibroblasts fails to induce hyperphosphorylation of transfected tau.

1 reference

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Detection of Phosphorylated Ser262 in Fetal Tau, Adult Tau, and Paired Helical Filament Tau

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Monoclonal antibody PHF-1 recognizes tau protein phosphorylated at serine residues 396 and 404.

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Intracellular signaling of angiotensin II-induced p70 S6 kinase phosphorylation at Ser(411) in vascular smooth muscle cells. Possible requirement of epidermal growth factor receptor, Ras, extracellular signal-regulated kinase, and Akt

1 reference

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7 January 2021

p42 map kinase phosphorylation sites in microtubule-associated protein tau are dephosphorylated by protein phosphatase 2A1Implications for Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9440%2810%2963445-1

7 January 2021

Activation of p38 kinase links tau phosphorylation, oxidative stress, and cell cycle-related events in Alzheimer disease

1 reference

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Role of protein phosphatase 2A in the regulation of mitogen-activated protein kinase activity in ventricular cardiomyocytes

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Adrenomedullin decreases extracellular signal-regulated kinase activity through an increase in protein phosphatase-2A activity in mesangial cells

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7 January 2021

Protein phosphatase-1 and protein phosphatase-2A from rabbit skeletal muscle

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7 January 2021

Insulin stimulates p70 S6 kinase in the nucleus of cells

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https://api.crossref.org/works/10.1016%2FS0002-9440%2810%2963445-1

7 January 2021

Detection of bromodeoxyuridine in formalin-fixed tissue. DNA denaturation following microwave or enzymatic digestion pretreatment is required

1 reference

https://pubmed.ncbi.nlm.nih.gov/12937126

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Complete Primary Structure of Protein Phosphatase Inhibitor-1 from Rabbit Skeletal Muscle

1 reference

https://pubmed.ncbi.nlm.nih.gov/12937126

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hydrofluoric acid-treated tau PHF proteins display the same biochemical properties as normal tau

1 reference

https://pubmed.ncbi.nlm.nih.gov/12937126

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/S0002-9440(10)63445-1

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

release_fdnt6pow3fcple5uaor6nhu4wa

1 reference

https://api.fatcat.wiki/v0/release/fdnt6pow3fcple5uaor6nhu4wa

24 November 2022

based on heuristic

mapped directly with Wikidata item

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

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