(Q46548202)

http://europepmc.org/abstract/MED/27179790

23 December 2017

title

Systems-level analysis of human aging genes shed new light on mechanisms of aging (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6390412&resulttype=core&format=json

13 May 2020

6

Jan Vijg

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6390412&resulttype=core&format=json

13 May 2020

author name string

Quanwei Zhang

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6390412&resulttype=core&format=json

13 May 2020

Ruben Nogales-Cadenas

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6390412&resulttype=core&format=json

13 May 2020

Jhih-Rong Lin

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6390412&resulttype=core&format=json

13 May 2020

Wen Zhang

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6390412&resulttype=core&format=json

13 May 2020

Ying Cai

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6390412&resulttype=core&format=json

13 May 2020

Zhengdong D Zhang

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6390412&resulttype=core&format=json

13 May 2020

publication date

14 May 2016

1 reference

http://europepmc.org/abstract/MED/27179790

23 December 2017

published in

Human Molecular Genetics

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6390412&resulttype=core&format=json

13 May 2020

volume

25

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6390412&resulttype=core&format=json

13 May 2020

page(s)

2934-2947

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6390412&resulttype=core&format=json

13 May 2020

issue

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6390412&resulttype=core&format=json

Answering the ultimate question "what is the proximal cause of aging?"

13 May 2020

cites work

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW145

Widespread protein aggregation as an inherent part of aging in C. elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW145

A network perspective on metabolism and aging.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW145

Lethality and centrality in protein networks

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW145

Preferential protection of protein interaction network hubs in yeast: evolved functionality of genetic redundancy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW145

Protein networks in disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW145

GenAge: a genomic and proteomic network map of human ageing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW145

A human protein interaction network shows conservation of aging processes between human and invertebrate species

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW145

Disease-aging network reveals significant roles of aging genes in connecting genetic diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW145

Human Ageing Genomic Resources: integrated databases and tools for the biology and genetics of ageing

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW145

Protein networks, pleiotropy and the evolution of senescence.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW145

Why do hubs in the yeast protein interaction network tend to be essential: reexamining the connection between the network topology and essentiality

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW145

Global topological features of cancer proteins in the human interactome

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW145

Evolution and topology in the yeast protein interaction network

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW145

Network strategies to understand the aging process and help age-related drug design.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW145

The Arf/p53 pathway in cancer and aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW145

High-betweenness proteins in the yeast protein interaction network

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW145

SubNet: a Java application for subnetwork extraction

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW145

Locally Weighted Regression: An Approach to Regression Analysis by Local Fitting

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW145

21 January 2018

The genetics of ageing

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW145

KEGG: kyoto encyclopedia of genes and genomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW145

Detecting overlapping protein complexes in protein-protein interaction networks

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW145

A modular network model of aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW145

Signaling networks in aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW145

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW145

HINT: High-quality protein interactomes and their applications in understanding human disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW145

Lifespan regulation by evolutionarily conserved genes essential for viability

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW145

MicroRNA-regulated protein-protein interaction networks: how could they help in searching for pro-longevity targets?

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW145

Molecular links between cellular senescence, longevity and age-related diseases - a systems biology perspective.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW145

Prediction of C. elegans longevity genes by human and worm longevity networks

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW145

Network medicine: a network-based approach to human disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW145

Specificity and stability in topology of protein networks

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW145

Proteomics. Tissue-based map of the human proteome

21 January 2018

2 references

https://api.crossref.org/works/10.1093%2FHMG%2FDDW145

21 January 2018

12 December 2020

Defining the transcriptome and proteome in three functionally different human cell lines

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW145

Mass-spectrometry-based draft of the human proteome

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW145

ProteinHistorian: tools for the comparative analysis of eukaryote protein origin

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW145

LongevityMap: a database of human genetic variants associated with longevity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW145

Analyses of human-chimpanzee orthologous gene pairs to explore evolutionary hypotheses of aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW145

The human protein coevolution network.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW145

Increased cell-to-cell variation in gene expression in ageing mouse heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW145

Age-dependent variability in gene expression in male Fischer 344 rat retina

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW145

Aging mice show a decreasing correlation of gene expression within genetic modules

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW145

The universal distribution of evolutionary rates of genes and distinct characteristics of eukaryotic genes of different apparent ages

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW145

Genetic evidence for common pathways in human age-related diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW145

McKusick's Online Mendelian Inheritance in Man (OMIM)

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW145

Determinants of the rate of protein sequence evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW145

Morbidity profiles of centenarians: survivors, delayers, and escapers

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW145

Cancer prevalence and mortality in centenarians: a systematic review.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW145

Health span approximates life span among many supercentenarians: compression of morbidity at the approximate limit of life span

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW145

Proteomic analysis of age-dependent changes in protein solubility identifies genes that modulate lifespan

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW145

Alternative Perspectives on Aging in Caenorhabditis elegans: Reactive Oxygen Species or Hyperfunction?

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW145

Programmatic features of aging originating in development: aging mechanisms beyond molecular damage?

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW145

Genomics of human longevity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW145

IL7R gene expression network associates with human healthy ageing

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW145

From mouse to human: evolutionary genomics analysis of human orthologs of essential genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW145

Human housekeeping genes, revisited

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW145

Large-scale gene function analysis with the PANTHER classification system

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW145

Benchmarking human protein complexes to investigate drug-related systems and evaluate predicted protein complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW145

Pfam: the protein families database

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW145

iPfam: a database of protein family and domain interactions found in the Protein Data Bank

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW145

COXPRESdb: a database of comparative gene coexpression networks of eleven species for mammals.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW145

Rank of correlation coefficient as a comparable measure for biological significance of gene coexpression

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW145

Error and attack tolerance of complex networks

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW145

Complex networks: two ways to be robust?

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW145

Determinants of substitution rates in mammalian genes: expression pattern affects selection intensity but not mutation rate

21 January 2018

1 reference

12 December 2020

Highly expressed genes in yeast evolve slowly.

1 reference

12 December 2020

Gene expression becomes heterogeneous with age

1 reference

12 December 2020

Common gene signature of cancer and longevity

1 reference

12 December 2020

Identifiers

DOI

10.1093/HMG/DDW145

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6390412&resulttype=core&format=json

13 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6390412&resulttype=core&format=json

13 May 2020

1 reference