(Q46549754)

English

PP2B isolated from human brain preferentially dephosphorylates Ser-262 and Ser-396 of the Alzheimer disease abnormally hyperphosphorylated tau.

scientific article published on 15 June 2005

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scholarly article

1 reference

Europe PubMed Central

23 December 2017

http://europepmc.org/abstract/MED/15959850

PP2B isolated from human brain preferentially dephosphorylates Ser-262 and Ser-396 of the Alzheimer disease abnormally hyperphosphorylated tau. (English)

1 reference

Europe PubMed Central

23 December 2017

http://europepmc.org/abstract/MED/15959850

author name string

A Rahman

1

1 reference

Europe PubMed Central

23 December 2017

http://europepmc.org/abstract/MED/15959850

I Grundke-Iqbal

2

1 reference

Europe PubMed Central

23 December 2017

http://europepmc.org/abstract/MED/15959850

K Iqbal

3

1 reference

Europe PubMed Central

23 December 2017

http://europepmc.org/abstract/MED/15959850

publication date

15 June 2005

1 reference

Europe PubMed Central

23 December 2017

http://europepmc.org/abstract/MED/15959850

Journal of Neural Transmission

1 reference

Europe PubMed Central

23 December 2017

http://europepmc.org/abstract/MED/15959850

113

1 reference

Europe PubMed Central

23 December 2017

http://europepmc.org/abstract/MED/15959850

219-230

1 reference

Europe PubMed Central

23 December 2017

http://europepmc.org/abstract/MED/15959850

2

1 reference

Europe PubMed Central

23 December 2017

http://europepmc.org/abstract/MED/15959850

https://scigraph.springernature.com/pub.10.1007/s00702-005-0313-5

0 references

Distribution of Alzheimer-type pathologic changes in nondemented elderly individuals matches the pattern in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1007%2FS00702-005-0313-5

21 January 2018

Dephosphorylation and deactivation of Ca2+/calmodulin-dependent protein kinase II in betaTC3-cells is mediated by Mg2+- and okadaic-acid-sensitive protein phosphatases

1 reference

https://api.crossref.org/works/10.1007%2FS00702-005-0313-5

21 January 2018

Tau pathology in Alzheimer disease and other tauopathies

1 reference

https://api.crossref.org/works/10.1007%2FS00702-005-0313-5

21 January 2018

Activation of the ERK and JNK signaling pathways caused by neuron-specific inhibition of PP2A in transgenic mice

1 reference

https://api.crossref.org/works/10.1007%2FS00702-005-0313-5

21 January 2018

Okadaic-acid-induced inhibition of protein phosphatase 2A produces activation of mitogen-activated protein kinases ERK1/2, MEK1/2, and p70 S6, similar to that in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1007%2FS00702-005-0313-5

21 January 2018

Calcineurin (phosphatase 2B) is present in neurons containing neurofibrillary tangles and in a subset of senile plaques in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15959850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduced protein phosphatase 2A activity induces hyperphosphorylation and altered compartmentalization of tau in transgenic mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15959850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytoskeletal changes in the brains of mice lacking calcineurin A alpha.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15959850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dephosphorylation of Alzheimer's disease abnormally phosphorylated tau by protein phosphatase-2A.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15959850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Indexing-based differential display--studies on post-mortem Alzheimer's brains.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15959850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The structure and regulation of protein phosphatases

1 reference

https://pubmed.ncbi.nlm.nih.gov/15959850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distinct Cellular Expression of Calcineurin Aα and Aβ in Rat Brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/15959850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Injection of bradykinin or cyclosporine A to hippocampus induces Alzheimer-like phosphorylation of Tau and abnormal behavior in rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15959850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation of microtubule-associated protein tau is regulated by protein phosphatase 2A in mammalian brain. Implications for neurofibrillary degeneration in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15959850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Post-translational modifications of tau protein in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/15959850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ser-262 in human recombinant tau protein is a markedly more favorable site for phosphorylation by CaMKII than PKA or PhK.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15959850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Promotion of hyperphosphorylation by frontotemporal dementia tau mutations

1 reference

https://pubmed.ncbi.nlm.nih.gov/15959850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of PP-2A upregulates CaMKII in rat forebrain and induces hyperphosphorylation of tau at Ser 262/356.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15959850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dephosphorylation of Alzheimer paired helical filaments by protein phosphatase-2A and -2B.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15959850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology

1 reference

https://pubmed.ncbi.nlm.nih.gov/15959850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of serine/threonine protein phosphatase in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/15959850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Observations on the brains of demented old people

1 reference

https://pubmed.ncbi.nlm.nih.gov/15959850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abnormal phosphorylation of tau and the mechanism of Alzheimer neurofibrillary degeneration: sequestration of microtubule-associated proteins 1 and 2 and the disassembly of microtubules by the abnormal tau

1 reference

https://pubmed.ncbi.nlm.nih.gov/15959850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Subcellular distribution of protein phosphatases and abnormally phosphorylated tau in the temporal cortex from Alzheimer's disease and control brains.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15959850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of protein phosphatases (PP-1, PP-2A, PP-2B and PTP-1B) and protein kinases (MAP kinase and P34cdc2) in the hippocampus of patients with Alzheimer disease and normal aged individuals.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15959850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation of tau at both Thr 231 and Ser 262 is required for maximal inhibition of its binding to microtubules

1 reference

https://pubmed.ncbi.nlm.nih.gov/15959850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Histopathological criteria for progressive dementia disorders: clinical-pathological correlation and classification by multivariate data analysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/15959850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calcineurin immunoreactivity in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15959850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stoichiometry and dynamic interaction of metal ion activators with calcineurin phosphatase

1 reference

https://pubmed.ncbi.nlm.nih.gov/15959850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple forms of phosphatase from human brain: isolation and partial characterization of affi-gel blue binding phosphatases.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15959850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of serine/threonine protein phosphatases on ion channels in excitable membranes

1 reference

https://pubmed.ncbi.nlm.nih.gov/15959850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphoprotein phosphatase activities in Alzheimer disease brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/15959850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microtubule-associated polypeptides tau are altered in Alzheimer paired helical filaments

1 reference

https://pubmed.ncbi.nlm.nih.gov/15959850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer's disease abnormally phosphorylated tau is dephosphorylated by protein phosphatase-2B (calcineurin).

1 reference

https://pubmed.ncbi.nlm.nih.gov/15959850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microtubule-associated protein tau. Abnormal phosphorylation of a non-paired helical filament pool in Alzheimer disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15959850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Restoration of biological activity of Alzheimer abnormally phosphorylated tau by dephosphorylation with protein phosphatase-2A, -2B and -1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15959850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microtubule-associated protein/microtubule affinity-regulating kinase (p110mark). A novel protein kinase that regulates tau-microtubule interactions and dynamic instability by phosphorylation at the Alzheimer-specific site serine 262

1 reference

https://pubmed.ncbi.nlm.nih.gov/15959850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphatase activity toward abnormally phosphorylated tau: decrease in Alzheimer disease brain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15959850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Localization of protein Ser/Thr phosphatase 5 in rat brain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15959850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The regulation of phosphorylation of tau in SY5Y neuroblastoma cells: the role of protein phosphatases.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15959850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calcium/calmodulin-dependent protein kinase II phosphorylates tau at Ser-262 but only partially inhibits its binding to microtubules

1 reference

https://pubmed.ncbi.nlm.nih.gov/15959850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation of Ser262 strongly reduces binding of tau to microtubules: distinction between PHF-like immunoreactivity and microtubule binding.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15959850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Elevated protein levels of protein phosphatases PP-2A and PP-2B in astrocytes of Alzheimer's disease temporal cortex

1 reference

https://pubmed.ncbi.nlm.nih.gov/15959850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dephosphorylation of microtubule-associated protein tau by protein phosphatase 5

1 reference

https://pubmed.ncbi.nlm.nih.gov/15959850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Up-regulation of calcineurin Abeta mRNA in the Alzheimer's disease brain: assessment by cDNA microarray

1 reference

https://pubmed.ncbi.nlm.nih.gov/15959850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dephosphorylation of microtubule-associated protein tau by protein phosphatase-1 and -2C and its implication in Alzheimer disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15959850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of abnormally phosphorylated tau in the breakdown of microtubules in Alzheimer disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/15959850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic overexpression of the calcineurin inhibitory gene DSCR1 (Adapt78) is associated with Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/15959850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hyperphosphorylation induces self-assembly of tau into tangles of paired helical filaments/straight filaments

1 reference

https://pubmed.ncbi.nlm.nih.gov/15959850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microtubule-associated protein tau. A component of Alzheimer paired helical filaments.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15959850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impairment of phosphatase 2A contributes to the prolonged MAP kinase phosphorylation in Alzheimer's disease fibroblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/15959850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dephosphorylation of tau by protein phosphatase 5: impairment in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/15959850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of calcineurin by metal ions. Mechanism of activation by Ni2+ and an enhanced response to Ca2+/calmodulin

1 reference

https://pubmed.ncbi.nlm.nih.gov/15959850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduction of calcineurin activity in brain by antisense oligonucleotides leads to persistent phosphorylation of tau protein at Thr181 and Thr231.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15959850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dephosphorylation of fetal-tau and paired helical filaments-tau by protein phosphatases 1 and 2A and calcineurin

1 reference

https://pubmed.ncbi.nlm.nih.gov/15959850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective changes of calcineurin (protein phosphatase 2B) activity in Alzheimer's disease cerebral cortex

1 reference

https://pubmed.ncbi.nlm.nih.gov/15959850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00702-005-0313-5

1 reference

Europe PubMed Central

23 December 2017

http://europepmc.org/abstract/MED/15959850

1 reference

Europe PubMed Central

23 December 2017

http://europepmc.org/abstract/MED/15959850

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