(Q46666883)

English

The novel Akt inhibitor, perifosine, induces caspase-dependent apoptosis and downregulates P-glycoprotein expression in multidrug-resistant human T-acute leukemia cells by a JNK-dependent mechanism

scientific article published on 3 April 2008

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/18385752

The novel Akt inhibitor, perifosine, induces caspase-dependent apoptosis and downregulates P-glycoprotein expression in multidrug-resistant human T-acute leukemia cells by a JNK-dependent mechanism (English)

1 reference

Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/18385752

multiple drug resistance

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

James A. McCubrey

8

1 reference

Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/18385752

author name string

F Chiarini

1

1 reference

Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/18385752

M Del Sole

2

1 reference

Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/18385752

S Mongiorgi

3

1 reference

Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/18385752

G C Gaboardi

4

1 reference

Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/18385752

A Cappellini

5

1 reference

Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/18385752

I Mantovani

6

1 reference

Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/18385752

M Y Follo

7

1 reference

Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/18385752

A M Martelli

9

1 reference

Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/18385752

publication date

3 April 2008

1 reference

Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/18385752

1 reference

Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/18385752

22

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Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/18385752

6

1 reference

Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/18385752

1106-1116

1 reference

Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/18385752

https://scigraph.springernature.com/pub.10.1038/leu.2008.79

0 references

Regulation of PTEN function as a PIP3 gatekeeper through membrane interaction

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.79

21 January 2018

A phase II trial of perifosine, an oral alkylphospholipid, in recurrent or metastatic head and neck cancer.

1 reference

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21 January 2018

A primer on the mechanics of P-glycoprotein the multidrug transporter.

1 reference

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7 January 2021

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ABC transporters and drug resistance in leukemia: was P-gp nothing but the first head of the Hydra?

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.79

7 January 2021

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Multidrug resistance in cancer: role of ATP-dependent transporters

1 reference

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7 January 2021

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The farnesyl transferase inhibitor, tipifarnib, is a potent inhibitor of the MDR1 gene product, P-glycoprotein, and demonstrates significant cytotoxic synergism against human leukemia cell lines

1 reference

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7 January 2021

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Onconase induces caspase-independent cell death in chemoresistant neuroblastoma cells

1 reference

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7 January 2021

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Identification of a novel synthetic thiazolidin compound capable of inducing c-Jun NH2-terminal kinase-dependent apoptosis in human colon cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.79

7 January 2021

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Phosphoinositide 3-kinase/Akt signaling pathway and its therapeutical implications for human acute myeloid leukemia.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.79

7 January 2021

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The insulin-like growth factor-I receptor kinase inhibitor NVP-AEW541 induces apoptosis in acute myeloid leukemia cells exhibiting autocrine insulin-like growth factor-I secretion

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.79

7 January 2021

based on heuristic

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Autocrine insulin-like growth factor-I signaling promotes growth and survival of human acute myeloid leukemia cells via the phosphoinositide 3-kinase/Akt pathway

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.79

7 January 2021

based on heuristic

inferred from DOI database lookup

AKT/PKB signaling: navigating downstream

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.79

7 January 2021

based on heuristic

inferred from DOI database lookup

The Akt/PKB pathway: molecular target for cancer drug discovery

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.79

7 January 2021

based on heuristic

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A phase I trial of perifosine (NSC 639966) on a loading dose/maintenance dose schedule in patients with advanced cancer

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.79

7 January 2021

based on heuristic

inferred from DOI database lookup

Edelfosine and perifosine induce selective apoptosis in multiple myeloma by recruitment of death receptors and downstream signaling molecules into lipid rafts.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.79

7 January 2021

based on heuristic

inferred from DOI database lookup

Phase I and pharmacological study of daily oral administration of perifosine (D-21266) in patients with advanced solid tumours

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.79

7 January 2021

based on heuristic

inferred from DOI database lookup

The alkylphospholipid perifosine induces apoptosis of human lung cancer cells requiring inhibition of Akt and activation of the extrinsic apoptotic pathway

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.79

7 January 2021

based on heuristic

inferred from DOI database lookup

Handicapping the race to develop inhibitors of the phosphoinositide 3-kinase/Akt/mammalian target of rapamycin pathway

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.79

7 January 2021

based on heuristic

inferred from DOI database lookup

Synergistic induction of apoptosis in human leukemia T cells by the Akt inhibitor perifosine and etoposide through activation of intrinsic and Fas-mediated extrinsic cell death pathways

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.79

7 January 2021

based on heuristic

inferred from DOI database lookup

Caspase-dependent cleavage of 170-kDa P-glycoprotein during apoptosis of human T-lymphoblastoid CEM cells

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.79

7 January 2021

based on heuristic

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Proapoptotic activity and chemosensitizing effect of the novel Akt inhibitor perifosine in acute myelogenous leukemia cells

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.79

7 January 2021

based on heuristic

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Rationale and clinical application of alkylphospholipid analogues in combination with radiotherapy

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.79

7 January 2021

based on heuristic

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A role for nuclear phospholipase Cbeta 1 in cell cycle control

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.79

7 January 2021

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Multidrug resistance-associated protein 1 expression is under the control of the phosphoinositide 3 kinase/Akt signal transduction network in human acute myelogenous leukemia blasts

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.79

7 January 2021

based on heuristic

inferred from DOI database lookup

Inhibition of phosphatidylinositol 3'-kinase induces preferentially killing of PTEN-null T leukemias through AKT pathway.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.79

7 January 2021

based on heuristic

inferred from DOI database lookup

Perifosine, an oral bioactive novel alkylphospholipid, inhibits Akt and induces in vitro and in vivo cytotoxicity in human multiple myeloma cells

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.79

7 January 2021

based on heuristic

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Enhancement of stress-induced apoptosis in B-lineage cells by caspase-9 inhibitor.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.79

7 January 2021

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Cytochrome c oxidase

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7 January 2021

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Thermodynamics of intersubunit interactions in cholera toxin upon binding to the oligosaccharide portion of its cell surface receptor, ganglioside GM1.

1 reference

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The antitumor ether lipid ET-18-OCH(3) induces apoptosis through translocation and capping of Fas/CD95 into membrane rafts in human leukemic cells

1 reference

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7 January 2021

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Structural and functional analyses of the promoter of the murine multidrug resistance gene mdr3/mdr1a reveal a negative element containing the AP-1 binding site

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.79

7 January 2021

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inferred from DOI database lookup

Reversal of P-glycoprotein-mediated multidrug resistance in cancer cells by the c-Jun NH2-terminal kinase

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.79

7 January 2021

based on heuristic

inferred from DOI database lookup

P-glycoprotein and 'lipid rafts': some ambiguous mutual relationships (floating on them, building them or meeting them by chance?).

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.79

7 January 2021

based on heuristic

inferred from DOI database lookup

Modulation of cellular cholesterol alters P-glycoprotein activity in multidrug-resistant cells

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.79

7 January 2021

based on heuristic

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A new class of anticancer alkylphospholipids uses lipid rafts as membrane gateways to induce apoptosis in lymphoma cells

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.79

7 January 2021

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inferred from DOI database lookup

Rapamycin stimulates apoptosis of childhood acute lymphoblastic leukemia cells

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.79

7 January 2021

based on heuristic

inferred from DOI database lookup

MDR1 protein expression is an independent predictor of complete remission in newly diagnosed adult acute lymphoblastic leukemia.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.79

7 January 2021

based on heuristic

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A reappraisal by quantitative flow cytometry analysis of PTEN expression in acute leukemia

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.79

7 January 2021

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Adult T-cell acute lymphoblastic leukemia: biologic profile at presentation and correlation with response to induction treatment in patients enrolled in the GIMEMA LAL 0496 protocol

1 reference

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7 January 2021

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Identifiers

10.1038/LEU.2008.79

1 reference

Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/18385752

release_j5n4w4fb4bgzrermapqkl65dxq

1 reference

https://api.fatcat.wiki/v0/release/j5n4w4fb4bgzrermapqkl65dxq

24 November 2022

based on heuristic

mapped directly with Wikidata item

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/18385752

ResearchGate publication ID

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