(Q56995355)

English

The insulin-like growth factor-I receptor kinase inhibitor NVP-AEW541 induces apoptosis in acute myeloid leukemia cells exhibiting autocrine insulin-like growth factor-I secretion

scientific article published on 15 March 2007

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scholarly article

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Europe PubMed Central

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27 December 2019

The insulin-like growth factor-I receptor kinase inhibitor NVP-AEW541 induces apoptosis in acute myeloid leukemia cells exhibiting autocrine insulin-like growth factor-I secretion (English)

1 reference

Europe PubMed Central

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27 December 2019

1 reference

based on heuristic

inferred from title

1 reference

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acute myeloid leukemia

1 reference

based on heuristic

inferred from title

apoptotic process

1 reference

based on heuristic

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Camilla Evangelisti

5

1 reference

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27 December 2019

James A. McCubrey

8

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27 December 2019

author name string

Tazzari PL

1

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27 December 2019

Tabellini G

2

1 reference

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27 December 2019

Bortul R

3

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27 December 2019

Papa V

4

1 reference

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27 December 2019

Grafone T

6

1 reference

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27 December 2019

Martinelli G

7

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27 December 2019

Martelli AM

9

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27 December 2019

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publication date

15 March 2007

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27 December 2019

1 reference

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27 December 2019

21

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27 December 2019

886-896

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27 December 2019

5

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27 December 2019

https://scigraph.springernature.com/pub.10.1038/sj.leu.2404643

0 references

The insulin-like growth factor system and cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404643

21 January 2018

IGF-I receptor signalling in transformation and differentiation

1 reference

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7 January 2021

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Type I insulin-like growth factor receptor as a therapeutic target in cancer

1 reference

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7 January 2021

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Targeting insulin-like growth factor pathways.

1 reference

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7 January 2021

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Role of the insulin-like growth factor family in cancer development and progression

1 reference

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7 January 2021

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The IGF‐1 receptor in cancer biology

1 reference

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7 January 2021

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Advances in biology of multiple myeloma: clinical applications

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7 January 2021

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Inhibition of the insulin-like growth factor receptor-1 tyrosine kinase activity as a therapeutic strategy for multiple myeloma, other hematologic malignancies, and solid tumors.

1 reference

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7 January 2021

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PI3-kinase/Akt is constitutively active in primary acute myeloid leukaemia cells and regulates survival and chemoresistance via NF-kappaB, Mapkinase and p53 pathways

1 reference

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7 January 2021

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Quantitative single cell determination of ERK phosphorylation and regulation in relapsed and refractory primary acute myeloid leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404643

7 January 2021

based on heuristic

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JAK/STAT, Raf/MEK/ERK, PI3K/Akt and BCR-ABL in cell cycle progression and leukemogenesis

1 reference

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7 January 2021

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Constitutive activation of PI3K is involved in the spontaneous proliferation of primary acute myeloid leukemia cells: direct evidence of PI3K activation.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404643

7 January 2021

based on heuristic

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Multidrug resistance-associated protein 1 expression is under the control of the phosphoinositide 3 kinase/Akt signal transduction network in human acute myelogenous leukemia blasts

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404643

7 January 2021

based on heuristic

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The phosphoinositide 3-kinase/Akt pathway regulates cell cycle progression of HL60 human leukemia cells through cytoplasmic relocalization of the cyclin-dependent kinase inhibitor p27(Kip1) and control of cyclin D1 expression

1 reference

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7 January 2021

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A new selective AKT pharmacological inhibitor reduces resistance to chemotherapeutic drugs, TRAIL, all-trans-retinoic acid, and ionizing radiation of human leukemia cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404643

7 January 2021

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Constitutively active Akt1 protects HL60 leukemia cells from TRAIL-induced apoptosis through a mechanism involving NF-kappaB activation and cFLIP(L) up-regulation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404643

7 January 2021

based on heuristic

inferred from DOI database lookup

Changes in apoptosis-related pathways in acute myelocytic leukemia

1 reference

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7 January 2021

based on heuristic

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Human growth hormone and insulin-like growth factor-1 enhance the proliferation of human leukemic blasts

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404643

7 January 2021

based on heuristic

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Growth factor receptors as therapeutic targets: strategies to inhibit the insulin-like growth factor I receptor

1 reference

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7 January 2021

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In vivo effects of the human type I insulin-like growth factor receptor antibody A12 on androgen-dependent and androgen-independent xenograft human prostate tumors

1 reference

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7 January 2021

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Synergy between an IGF-1R antibody and Raf/MEK/ERK and PI3K/Akt/mTOR pathway inhibitors in suppressing IGF-1R-mediated growth in hematopoietic cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404643

7 January 2021

based on heuristic

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Substrate competitive inhibitors of IGF-1 receptor kinase

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

In vivo antitumor activity of NVP-AEW541-A novel, potent, and selective inhibitor of the IGF-IR kinase

1 reference

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7 January 2021

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Insulin-like growth factors 1 and 2 induce lymphangiogenesis in vivo

1 reference

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7 January 2021

based on heuristic

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Differential expression of IGF components and insulin receptor isoforms in human seminoma versus normal testicular tissue

1 reference

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7 January 2021

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Phosphoinositide 3-kinase/Akt involvement in arsenic trioxide resistance of human leukemia cells

1 reference

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7 January 2021

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Antitumor activity of the insulin-like growth factor-I receptor kinase inhibitor NVP-AEW541 in musculoskeletal tumors.

1 reference

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7 January 2021

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Blockade of IGF-1 receptor tyrosine kinase has antineoplastic effects in hepatocellular carcinoma cells

1 reference

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7 January 2021

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PI3K-FRAP/mTOR pathway is critical for hepatocyte proliferation whereas MEK/ERK supports both proliferation and survival

1 reference

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7 January 2021

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Determinants of rapamycin sensitivity in breast cancer cells

1 reference

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7 January 2021

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Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization

1 reference

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7 January 2021

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PTEN and GSK3beta: key regulators of progression to androgen-independent prostate cancer

1 reference

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7 January 2021

based on heuristic

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Stopping and going with p27kip1.

1 reference

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7 January 2021

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Negative cell cycle regulator 14-3-3sigma stabilizes p27 Kip1 by inhibiting the activity of PKB/Akt.

1 reference

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7 January 2021

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inferred from DOI database lookup

Insulin-like growth factor receptor I targeting in epithelial ovarian cancer

1 reference

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7 January 2021

based on heuristic

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Apoptosis effector mechanisms: a requiem performed in different keys

1 reference

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The role of the IGF system in cancer growth and metastasis: overview and recent insights

1 reference

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7 January 2021

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The inhibitors of apoptosis: there is more to life than Bcl2.

1 reference

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7 January 2021

based on heuristic

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Regulation of apoptosis by insulin-like growth factor (IGF)-I.

1 reference

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Phosphoinositide 3-kinase/Akt signaling pathway and its therapeutical implications for human acute myeloid leukemia.

1 reference

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7 January 2021

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Constitutive NF-κB DNA-binding activity in AML is frequently mediated by a Ras/PI3-K/PKB-dependent pathway

1 reference

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1 reference

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1 reference

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