(Q44557868)

English

The phosphoinositide 3-kinase/Akt pathway regulates cell cycle progression of HL60 human leukemia cells through cytoplasmic relocalization of the cyclin-dependent kinase inhibitor p27(Kip1) and control of cyclin D1 expression

scientific article published in November 2003

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scholarly article

1 reference

Europe PubMed Central

4 December 2017

The phosphoinositide 3-kinase/Akt pathway regulates cell cycle progression of HL60 human leukemia cells through cytoplasmic relocalization of the cyclin-dependent kinase inhibitor p27(Kip1) and control of cyclin D1 expression (English)

1 reference

Europe PubMed Central

4 December 2017

author name string

Cappellini A

1

1 reference

Europe PubMed Central

4 December 2017

Tabellini G

2

1 reference

Europe PubMed Central

4 December 2017

Zweyer M

3

1 reference

Europe PubMed Central

4 December 2017

Bortul R

4

1 reference

Europe PubMed Central

4 December 2017

Tazzari PL

5

1 reference

Europe PubMed Central

4 December 2017

Billi AM

6

1 reference

Europe PubMed Central

4 December 2017

Falà F

7

1 reference

Europe PubMed Central

4 December 2017

Cocco L

8

1 reference

Europe PubMed Central

4 December 2017

Martelli AM

9

1 reference

Europe PubMed Central

4 December 2017

publication date

1 November 2003

1 reference

Europe PubMed Central

4 December 2017

1 reference

Europe PubMed Central

4 December 2017

17

1 reference

Europe PubMed Central

4 December 2017

2157-2167

1 reference

Europe PubMed Central

4 December 2017

11

1 reference

Europe PubMed Central

4 December 2017

https://scigraph.springernature.com/pub.10.1038/sj.leu.2403111

0 references

AKT plays a central role in tumorigenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403111

21 January 2018

The protein kinase B/Akt signalling pathway in human malignancy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403111

21 January 2018

Cellular function of phosphoinositide 3-kinases: implications for development, homeostasis, and cancer.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403111

21 January 2018

Ten years of protein kinase B signalling: a hard Akt to follow

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403111

21 January 2018

Activation of NF-kappaB and upregulation of intracellular anti-apoptotic proteins via the IGF-1/Akt signaling in human multiple myeloma cells: therapeutic implications

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403111

21 January 2018

CREB is a regulatory target for the protein kinase Akt/PKB

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403111

21 January 2018

Akt/protein kinase B up-regulates Bcl-2 expression through cAMP-response element-binding protein.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403111

21 January 2018

Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403111

21 January 2018

Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403111

21 January 2018

Direct control of the Forkhead transcription factor AFX by protein kinase B

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403111

21 January 2018

Inhibition of nuclear import by protein kinase B (Akt) regulates the subcellular distribution and activity of the forkhead transcription factor AFX.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403111

21 January 2018

The forkhead transcription factor FoxO regulates transcription of p27Kip1 and Bim in response to IL-2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403111

21 January 2018

Flow cytometric detection of total and serine 473 phosphorylated Akt.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403111

21 January 2018

Constitutively active Akt1 protects HL60 leukemia cells from TRAIL-induced apoptosis through a mechanism involving NF-kappaB activation and cFLIP(L) up-regulation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403111

21 January 2018

Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403111

21 January 2018

Safety and antitumor activity of recombinant soluble Apo2 ligand

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403111

21 January 2018

The nuclear phosphoinositide 3-kinase/AKT pathway: a new second messenger system.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403111

21 January 2018

p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403111

21 January 2018

Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403111

21 January 2018

PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403111

21 January 2018

DNA replication in eukaryotic cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403111

21 January 2018

Forkhead transcription factors are targets of signalling by the proto-oncogene PKB (C-AKT).

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403111

21 January 2018

Cell cycle and death control: long live Forkheads

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403111

21 January 2018

New roles for p21 and p27 cell-cycle inhibitors: a function for each cell compartment?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403111

21 January 2018

Regulation of cyclin-Cdk activity in mammalian cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403111

21 January 2018

Regulation of G(1) cell-cycle progression by oncogenes and tumor suppressor genes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403111

21 January 2018

Checking out the G(2)/M transition.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403111

21 January 2018

CDK inhibitors: positive and negative regulators of G1-phase progression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403111

21 January 2018

PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403111

21 January 2018

Retinoblastoma protein-overexpressing HL60 cells resistant to 1,25-dihydroxyvitamin D3 display increased CDK2 and CDK6 activity and shortened G1 phase.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403111

21 January 2018

Mutational analysis of the tumour suppressor gene MMAC1/PTEN in malignant myeloid disorders

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403111

21 January 2018

Mutation analysis of PTEN/MMAC1 in acute myeloid leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403111

21 January 2018

Possible dominant-negative mutation of the SHIP gene in acute myeloid leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403111

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403111

21 January 2018

Regulation of myeloma cell growth through Akt/Gsk3/forkhead signaling pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403111

21 January 2018

Inactivation of the forkhead transcription factor FoxO3 is essential for PKB-mediated survival of hematopoietic progenitor cells by kit ligand

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403111

21 January 2018

Activation of phosphatidylinositol 3-kinase is important for erythropoietin-induced erythropoiesis from CD34(+) hematopoietic progenitor cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403111

21 January 2018

A member of Forkhead transcription factor FKHRL1 is a downstream effector of STI571-induced cell cycle arrest in BCR-ABL-expressing cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403111

21 January 2018

PTEN is inversely correlated with the cell survival factor Akt/PKB and is inactivated via multiple mechanismsin haematological malignancies

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403111

21 January 2018

Breast cancer banishes p27 from nucleus

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403111

7 January 2021

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10.1038/SJ.LEU.2403111

1 reference

Europe PubMed Central

4 December 2017

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1 reference

Europe PubMed Central

4 December 2017

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