(Q46723109)

24 December 2017

title

Cucurbitacin B induces DNA damage and autophagy mediated by reactive oxygen species (ROS) in MCF-7 breast cancer cells (English)

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24 December 2017

main subject

reactive oxygen species

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5

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24 December 2017

author name string

Guowen Ren

1

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24 December 2017

Tongye Sha

2

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24 December 2017

Jiajie Guo

3

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24 December 2017

Wenxue Li

4

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24 December 2017

Xiuping Chen

6

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24 December 2017

publication date

28 May 2015

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24 December 2017

Journal of Natural Medicines

published in

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24 December 2017

volume

69

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24 December 2017

issue

4

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24 December 2017

page(s)

522-530

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24 December 2017

https://scigraph.springernature.com/pub.10.1007/s11418-015-0918-4

exact match

0 references

cites work

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Inhibitory effects of cucurbitacin B on laryngeal squamous cell carcinoma

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Cucurbitacin B induces apoptosis by inhibition of the JAK/STAT pathway and potentiates antiproliferative effects of gemcitabine on pancreatic cancer cells

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Targeted constitutive activation of signal transducer and activator of transcription 3 in human hepatocellular carcinoma cells by cucurbitacin B.

21 January 2018

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Cucurbitacin B induces apoptosis and S phase cell cycle arrest in BEL-7402 human hepatocellular carcinoma cells and is effective via oral administration

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Cucurbitacin B induces rapid depletion of the G-actin pool through reactive oxygen species-dependent actin aggregation in melanoma cells.

21 January 2018

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Cucurbitacin B, a small molecule inhibitor of the Stat3 signaling pathway, enhances the chemosensitivity of laryngeal squamous cell carcinoma cells to cisplatin

21 January 2018

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The triterpenoid cucurbitacin B augments the antiproliferative activity of chemotherapy in human breast cancer

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Inhibition of Integrin-HER2 signaling by Cucurbitacin B leads to in vitro and in vivo breast tumor growth suppression

21 January 2018

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Cucurbitacin B inhibits human breast cancer cell proliferation through disruption of microtubule polymerization and nucleophosmin/B23 translocation

21 January 2018

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Antiproliferative effects of cucurbitacin B in breast cancer cells: down-regulation of the c-Myc/hTERT/telomerase pathway and obstruction of the cell cycle

21 January 2018

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Cucurbitacin B has a potent antiproliferative effect on breast cancer cells in vitro and in vivo

21 January 2018

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Inhibition of Wnt signaling by cucurbitacin B in breast cancer cells: reduction of Wnt-associated proteins and reduced translocation of galectin-3-mediated β-catenin to the nucleus.

21 January 2018

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Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling

21 January 2018

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Oxidative stress and autophagy: the clash between damage and metabolic needs

21 January 2018

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Cucurbitacin B induced ATM-mediated DNA damage causes G2/M cell cycle arrest in a ROS-dependent manner

21 January 2018

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Cucurbitacin B induces DNA damage, G2/M phase arrest, and apoptosis mediated by reactive oxygen species (ROS) in leukemia K562 cells

21 January 2018

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21 January 2018

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DNA damage sensing by the ATM and ATR kinases.

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Cucurbitacin induces autophagy through mitochondrial ROS production which counteracts to limit caspase-dependent apoptosis.

21 January 2018

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21 January 2018

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Cucurbitacin B induces cell cycle arrest, apoptosis and autophagy associated with G actin reduction and persistent activation of cofilin in Jurkat cells.

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Regulation of autophagy by reactive oxygen species (ROS): implications for cancer progression and treatment

21 January 2018

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DNA damage-induced activation of ATM and ATM-dependent signaling pathways

21 January 2018

1 reference

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Cucurbitacin B induces G2 arrest and apoptosis via a reactive oxygen species-dependent mechanism in human colon adenocarcinoma SW480 cells

21 January 2018

1 reference

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A novel assay to study autophagy: regulation of autophagosome vacuole size by amino acid deprivation.

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26018422

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1007/S11418-015-0918-4

1 reference

24 December 2017

PubMed ID

26018422

1 reference

24 December 2017