(Q37687078)

22 August 2017

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title

gammaH2AX: a sensitive molecular marker of DNA damage and repair (English)

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22 August 2017

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L-J Mah

1

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22 August 2017

A El-Osta

series ordinal

2

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22 August 2017

T C Karagiannis

series ordinal

3

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22 August 2017

publication date

4 February 2010

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22 August 2017

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22 August 2017

volume

24

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22 August 2017

issue

4

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22 August 2017

page(s)

679-686

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Double-strand breaks: signaling pathways and repair mechanisms.

22 August 2017

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Response to RAG-mediated VDJ cleavage by NBS1 and gamma-H2AX

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HP1-beta mobilization promotes chromatin changes that initiate the DNA damage response.

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Gamma-H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin

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Microscopic imaging of DNA repair foci in irradiated normal tissues.

21 January 2018

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DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139

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MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks

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Differential usage of non-homologous end-joining and homologous recombination in double strand break repair

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Regulation of DNA double-strand break repair pathway choice

21 January 2018

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Role of non-homologous end joining (NHEJ) in maintaining genomic integrity

21 January 2018

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Pathways of DNA double-strand break repair during the mammalian cell cycle

21 January 2018

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The type and yield of ionising radiation induced chromosomal aberrations depend on the efficiency of different DSB repair pathways in mammalian cells

21 January 2018

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Homologous recombination and non-homologous end-joining pathways of DNA double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells

21 January 2018

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Molecular views of recombination proteins and their control

21 January 2018

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Regulation and mechanisms of mammalian double-strand break repair

21 January 2018

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Sister chromatid gene conversion is a prominent double-strand break repair pathway in mammalian cells

21 January 2018

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Phospho-dependent interactions between NBS1 and MDC1 mediate chromatin retention of the MRN complex at sites of DNA damage

21 January 2018

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The loss of gammaH2AX signal is a marker of DNA double strand breaks repair only at low levels of DNA damage

21 January 2018

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Radiation sensitivity, H2AX phosphorylation, and kinetics of repair of DNA strand breaks in irradiated cervical cancer cell lines

21 January 2018

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Control of sister chromatid recombination by histone H2AX.

21 January 2018

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Postreplicative recruitment of cohesin to double-strand breaks is required for DNA repair.

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2010.6

DNA damage response pathway uses histone modification to assemble a double-strand break-specific cohesin domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.6

Genomic instability in mice lacking histone H2AX

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2010.6

Positional stability of single double-strand breaks in mammalian cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2010.6

H2AX haploinsufficiency modifies genomic stability and tumor susceptibility

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2010.6

DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1

21 January 2018

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Human DNA-activated protein kinase phosphorylates serines 15 and 37 in the amino-terminal transactivation domain of human p53.

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2010.6

Focus formation of DNA repair proteins in normal and repair-deficient cells irradiated with high-LET ions

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2010.6

Induction and quantification of gamma-H2AX foci following low and high LET-irradiation

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2010.6

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2010.6

Checkpoint signaling: epigenetic events sound the DNA strand-breaks alarm to the ATM protein kinase

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2010.6

Characteristics of gamma-H2AX foci at DNA double-strand breaks sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.6

A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.6

ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.6

Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.6

P53 and radiation responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.6

A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.6

ATR-dependent phosphorylation and activation of ATM in response to UV treatment or replication fork stalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.6

Chromatin modifications and their function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.6

DNA damage-induced activation of ATM and ATM-dependent signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.6

Specific ATM-mediated phosphorylation dependent on radiation quality

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2010.6

Imaging features that discriminate between foci induced by high- and low-LET radiation in human fibroblasts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.6

Radiation sensitivity and cancer in ataxia-telangiectasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.6

The DNA damage response: putting checkpoints in perspective

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2010.6

CHK2 kinase--a busy messenger.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.6

Formation of dynamic gamma-H2AX domains along broken DNA strands is distinctly regulated by ATM and MDC1 and dependent upon H2AX densities in chromatin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.6

Kinetics and dose-response of residual 53BP1/gamma-H2AX foci: co-localization, relationship with DSB repair and clonogenic survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.6

A phosphatase complex that dephosphorylates gammaH2AX regulates DNA damage checkpoint recovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.6

Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.6

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.6

GammaH2AX in cancer cells: a potential biomarker for cancer diagnostics, prediction and recurrence

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.6

Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.6

Phosphorylation of histone H2AX as a measure of radiosensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.6

Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.6

DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.6

H2AX phosphorylation as a genotoxicity endpoint.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.6

γ-H2AX as a biomarker of DNA damage induced by ionizing radiation in human peripheral blood lymphocytes and artificial skin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.6

Homologous recombination as a potential target for caffeine radiosensitization in mammalian cells: reduced caffeine radiosensitization in XRCC2 and XRCC3 mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.6

The Mre11/Rad50/Nbs1 complex and its role as a DNA double-strand break sensor for ATM.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.6

H2AX: the histone guardian of the genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.6

p53 binding protein 1 (53BP1) is an early participant in the cellular response to DNA double-strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.6

Beyond repair foci: subnuclear domains and the cellular response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.6

H2AX phosphorylation within the G1 phase after UV irradiation depends on nucleotide excision repair and not DNA double-strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.6

Phosphorylation of histone H2AX at M phase in human cells without DNA damage response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.6

H2AX is required for chromatin remodeling and inactivation of sex chromosomes in male mouse meiosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.6

Distinct BRCT domains in Mcph1/Brit1 mediate ionizing radiation-induced focus formation and centrosomal localization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.6

Biomarkers for DNA DSB inhibitors and radiotherapy clinical trials

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.6

Binding of chromatin-modifying activities to phosphorylated histone H2A at DNA damage sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.6

INO80 and gamma-H2AX interaction links ATP-dependent chromatin remodeling to DNA damage repair.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.6

DNA damage-dependent acetylation and ubiquitination of H2AX enhances chromatin dynamics

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.6

gamma-H2AX dephosphorylation by protein phosphatase 2A facilitates DNA double-strand break repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.6

PP4 is a gamma H2AX phosphatase required for recovery from the DNA damage checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.6

Connection between histone H2A variants and chromatin remodeling complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.6

Acetylation by Tip60 is required for selective histone variant exchange at DNA lesions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.6

UV-induced replication arrest in the xeroderma pigmentosum variant leads to DNA double-strand breaks, gamma -H2AX formation, and Mre11 relocalization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.6

UV-induced ataxia-telangiectasia-mutated and Rad3-related (ATR) activation requires replication stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.6

Disparity of histone deacetylase inhibition on repair of radiation-induced DNA damage on euchromatin and constitutive heterochromatin compartments.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.6

ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.6

gammaH2AX foci form preferentially in euchromatin after ionising-radiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.6

Signatures of DNA double strand breaks produced in irradiated G1 and G2 cells persist into mitosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.6

A review of the bystander effect and its implications for low-dose exposure

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.6

Cellular radiation effects and the bystander response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.6

Bystander effect for chromosomal aberrations induced in wild-type and repair deficient CHO cells by low fluences of alpha particles

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.6

Variability: the common factor linking low dose-induced genomic instability, adaptation and bystander effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.6

Radiation-induced bystander effects: evidence for an adaptive response to low dose exposures?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.6

ATR-dependent radiation-induced gamma H2AX foci in bystander primary human astrocytes and glioma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.6

Ionizing radiation induces DNA double-strand breaks in bystander primary human fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.6

gamma-H2AX in bystander cells: not just a radiation-triggered event, a cellular response to stress mediated by intercellular communication

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.6

A microbeam study of DNA double-strand breaks in bystander primary human fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.6

The time and spatial effects of bystander response in mammalian cells induced by low dose radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.6

Constitutive nitric oxide acting as a possible intercellular signaling molecule in the initiation of radiation-induced DNA double strand breaks in non-irradiated bystander cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.6

Radical causes of cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.6

Oxyradicals and DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.6

21 January 2018

UV-induced skin damage

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.6

Constitutive histone H2AX phosphorylation and ATM activation, the reporters of DNA damage by endogenous oxidants

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.6

Initial steps of ferulic acid polymerization by lignin peroxidase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.6

"ATR activation in response to ionizing radiation: still ATM territory".

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.6

Oxidative stress in environmental-induced carcinogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.6

ATR-Chk2 signaling in p53 activation and DNA damage response during cisplatin-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.6

Histone H2AX phosphorylation as a molecular pharmacological marker for DNA interstrand crosslink cancer chemotherapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.6

Kinetics of H2AX phosphorylation after exposure to cisplatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.6

Topoisomerase I-mediated DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.6

Phosphorylated histone H2AX in spheroids, tumors, and tissues of mice exposed to etoposide and 3-amino-1,2,4-benzotriazine-1,3-dioxide

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.6

Cytometry of ATM activation and histone H2AX phosphorylation to estimate extent of DNA damage induced by exogenous agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.6

The S-phase cytotoxicity of camptothecin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.6

Effect of valproic acid on radiation-induced DNA damage in euchromatic and heterochromatic compartments

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.6

Fibroblast growth factor receptor 3 inhibition by short hairpin RNAs leads to apoptosis in multiple myeloma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.6

Postradiation sensitization of the histone deacetylase inhibitor valproic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.6

Dimethyl sulfoxide to vorinostat: development of this histone deacetylase inhibitor as an anticancer drug

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.6

Anticancer activities of histone deacetylase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.6

Histone deacetylase inhibitors: molecular mechanisms of action

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.6

Histone deacetylase inhibitors sensitize prostate cancer cells to agents that produce DNA double-strand breaks by targeting Ku70 acetylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.6

Antileukemia activity of the combination of an anthracycline with a histone deacetylase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.6

Early epigenetic changes and DNA damage do not predict clinical response in an overlapping schedule of 5-azacytidine and entinostat in patients with myeloid malignancies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.6

gammaH2AX: A potential DNA damage response biomarker for assessing toxicological risk of tobacco products

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.6

Histone H2AX in DNA damage and repair.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.6

7 January 2021

Epigenetic changes activate widespread signals in response to double-strand breaks.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.6

7 January 2021

Low-dose hypersensitive gammaH2AX response and infrequent apoptosis in epidermis from radiotherapy patients

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.6

7 January 2021

gamma-H2AX foci after low-dose-rate irradiation reveal atm haploinsufficiency in mice

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.6

7 January 2021

Chromatin dynamics coupled to DNA repair

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.6

7 January 2021

Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.6

7 January 2021

The histone deacetylase inhibitor, Trichostatin A, enhances radiation sensitivity and accumulation of gammaH2A.X.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.6

7 January 2021

Identifiers

DOI

10.1038/LEU.2010.6

1 reference

22 August 2017

1 reference