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English
DNA damage sensing by the ATM and ATR kinases.
scientific article published on September 2013
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Europe PubMed Central
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3753707
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24003211%20AND%20SRC:MED&resulttype=core&format=json
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19 February 2020
title
DNA damage sensing by the ATM and ATR kinases
(English)
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stated in
Europe PubMed Central
PMCID
3753707
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24003211%20AND%20SRC:MED&resulttype=core&format=json
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19 February 2020
main subject
DNA damage
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author
Alexandre Maréchal
series ordinal
1
1 reference
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Europe PubMed Central
PMCID
3753707
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24003211%20AND%20SRC:MED&resulttype=core&format=json
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19 February 2020
author name string
Lee Zou
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2
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Europe PubMed Central
PMCID
3753707
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19 February 2020
publication date
1 September 2013
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Europe PubMed Central
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19 February 2020
published in
Cold Spring Harbor Perspectives in Biology
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Europe PubMed Central
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3753707
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19 February 2020
volume
5
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Europe PubMed Central
PMCID
3753707
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24003211%20AND%20SRC:MED&resulttype=core&format=json
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19 February 2020
issue
9
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stated in
Europe PubMed Central
PMCID
3753707
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24003211%20AND%20SRC:MED&resulttype=core&format=json
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19 February 2020
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Structure of Mre11–Nbs1 complex yields insights into ataxia-telangiectasia–like disease mutations and DNA damage signaling
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Human nuclease/helicase DNA2 alleviates replication stress by promoting DNA end resection
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A genome-wide homologous recombination screen identifies the RNA-binding protein RBMX as a component of the DNA-damage response
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Exo1 plays a major role in DNA end resection in humans and influences double-strand break repair and damage signaling decisions
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ATR-ATRIP kinase complex triggers activation of the Fanconi anemia DNA repair pathway
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The ubiquitin-selective segregase VCP/p97 orchestrates the response to DNA double-strand breaks.
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More than just a focus: The chromatin response to DNA damage and its role in genome integrity maintenance
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The unstructured C-terminal tail of yeast Dpb11 (human TopBP1) protein is dispensable for DNA replication and the S phase checkpoint but required for the G2/M checkpoint.
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Double-strand break end resection and repair pathway choice
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BID binds to replication protein A and stimulates ATR function following replicative stress
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ATR autophosphorylation as a molecular switch for checkpoint activation.
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Oligomerization of MDC1 protein is important for proper DNA damage response
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6 September 2017
Thr-1989 phosphorylation is a marker of active ataxia telangiectasia-mutated and Rad3-related (ATR) kinase
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6 September 2017
A DNA damage response screen identifies RHINO, a 9-1-1 and TopBP1 interacting protein required for ATR signaling
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ATR signalling: more than meeting at the fork
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MDC1 collaborates with TopBP1 in DNA replication checkpoint control
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ATM damage response and XLF repair factor are functionally redundant in joining DNA breaks
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The ATM-Chk2 and ATR-Chk1 pathways in DNA damage signaling and cancer
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6 September 2017
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A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability
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Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes
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A genome-scale DNA repair RNAi screen identifies SPG48 as a novel gene associated with hereditary spastic paraplegia
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6 September 2017
53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks
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6 September 2017
Xenopus DNA2 is a helicase/nuclease that is found in complexes with replication proteins And-1/Ctf4 and Mcm10 and DSB response proteins Nbs1 and ATM
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ATR suppresses telomere fragility and recombination but is dispensable for elongation of short telomeres by telomerase
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Rad17 plays a central role in establishment of the interaction between TopBP1 and the Rad9-Hus1-Rad1 complex at stalled replication forks
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Autophosphorylation at serine 1981 stabilizes ATM at DNA damage sites
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HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes
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Phosphorylation of Exo1 modulates homologous recombination repair of DNA double-strand breaks
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6 September 2017
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6 September 2017
Formation of dynamic gamma-H2AX domains along broken DNA strands is distinctly regulated by ATM and MDC1 and dependent upon H2AX densities in chromatin.
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6 September 2017
Distinct roles of ATR and DNA-PKcs in triggering DNA damage responses in ATM-deficient cells
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6 September 2017
Solving the RIDDLE of 53BP1 recruitment to sites of damage
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6 September 2017
The Mre11-Rad50-Nbs1 complex mediates activation of TopBP1 by ATM
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6 September 2017
RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins
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6 September 2017
Dpb11 activates the Mec1-Ddc2 complex
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6 September 2017
Yeast DNA replication protein Dpb11 activates the Mec1/ATR checkpoint kinase
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6 September 2017
Mre11 nuclease activity has essential roles in DNA repair and genomic stability distinct from ATM activation
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6 September 2017
Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer
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6 September 2017
Activation of ATR and related PIKKs
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6 September 2017
MDC1 regulates intra-S-phase checkpoint by targeting NBS1 to DNA double-strand breaks
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ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin
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6 September 2017
Mre11-Rad50-Nbs1-dependent processing of DNA breaks generates oligonucleotides that stimulate ATM activity
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6 September 2017
ATR: an essential regulator of genome integrity
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6 September 2017
Phospho-dependent interactions between NBS1 and MDC1 mediate chromatin retention of the MRN complex at sites of DNA damage
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6 September 2017
Phosphorylation of the budding yeast 9-1-1 complex is required for Dpb11 function in the full activation of the UV-induced DNA damage checkpoint
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6 September 2017
TopBP1 activates ATR through ATRIP and a PIKK regulatory domain
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PubMed Central
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6 September 2017
Constitutive phosphorylation of MDC1 physically links the MRE11-RAD50-NBS1 complex to damaged chromatin
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PubMed Central
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6 September 2017
Phosphorylation of SDT repeats in the MDC1 N terminus triggers retention of NBS1 at the DNA damage-modified chromatin
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PubMed Central
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6 September 2017
Cryo-EM structure of the DNA-dependent protein kinase catalytic subunit at subnanometer resolution reveals alpha helices and insight into DNA binding
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6 September 2017
An oncogene-induced DNA damage model for cancer development
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6 September 2017
Tel2 regulates the stability of PI3K-related protein kinases
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6 September 2017
Profiling of UV-induced ATM/ATR signaling pathways.
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6 September 2017
Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3753707
retrieved
6 September 2017
Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3753707
retrieved
6 September 2017
RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3753707
retrieved
6 September 2017
RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3753707
retrieved
6 September 2017
Human CtIP promotes DNA end resection
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3753707
retrieved
6 September 2017
Rapid activation of ATM on DNA flanking double-strand breaks
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3753707
retrieved
6 September 2017
Ctp1 is a cell-cycle-regulated protein that functions with Mre11 complex to control double-strand break repair by homologous recombination
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3753707
retrieved
6 September 2017
DNA damage-induced acetylation of lysine 3016 of ATM activates ATM kinase activity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3753707
retrieved
6 September 2017
Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3753707
retrieved
6 September 2017
Ubiquitin-binding protein RAP80 mediates BRCA1-dependent DNA damage response
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3753707
retrieved
6 September 2017
RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3753707
retrieved
6 September 2017
Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3753707
retrieved
6 September 2017
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3753707
retrieved
6 September 2017
Spreading of mammalian DNA-damage response factors studied by ChIP-chip at damaged telomeres
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3753707
retrieved
6 September 2017
p53-deficient cells rely on ATM- and ATR-mediated checkpoint signaling through the p38MAPK/MK2 pathway for survival after DNA damage
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3753707
retrieved
6 September 2017
The checkpoint clamp activates Mec1 kinase during initiation of the DNA damage checkpoint
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3753707
retrieved
6 September 2017
ATR-dependent phosphorylation and activation of ATM in response to UV treatment or replication fork stalling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3753707
retrieved
6 September 2017
TopBP1 activates the ATR-ATRIP complex
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3753707
retrieved
6 September 2017
Rapid activation of ATR by ionizing radiation requires ATM and Mre11
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3753707
retrieved
6 September 2017
MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3753707
retrieved
6 September 2017
ATRIP associates with replication protein A-coated ssDNA through multiple interactions
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3753707
retrieved
6 September 2017
MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3753707
retrieved
6 September 2017
ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3753707
retrieved
6 September 2017
Dimerization of the ATRIP protein through the coiled-coil motif and its implication to the maintenance of stalled replication forks
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3753707
retrieved
6 September 2017
A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3753707
retrieved
6 September 2017
ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3753707
retrieved
6 September 2017
Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3753707
retrieved
6 September 2017
ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3753707
retrieved
6 September 2017
Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3753707
retrieved
6 September 2017
ATRIP binding to replication protein A-single-stranded DNA promotes ATR-ATRIP localization but is dispensable for Chk1 phosphorylation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3753707
retrieved
6 September 2017
The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3753707
retrieved
6 September 2017
Functional interaction of H2AX, NBS1, and p53 in ATM-dependent DNA damage responses and tumor suppression
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3753707
retrieved
6 September 2017
BRCA1-BARD1 complexes are required for p53Ser-15 phosphorylation and a G1/S arrest following ionizing radiation-induced DNA damage
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3753707
retrieved
6 September 2017
Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3753707
retrieved
6 September 2017
Biochemical characterization of DNA damage checkpoint complexes: clamp loader and clamp complexes with specificity for 5' recessed DNA
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3753707
retrieved
6 September 2017
Replication protein A-mediated recruitment and activation of Rad17 complexes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3753707
retrieved
6 September 2017
Requirement of the MRN complex for ATM activation by DNA damage
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3753707
retrieved
6 September 2017
Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3753707
retrieved
6 September 2017
Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3753707
retrieved
6 September 2017
ATM and related protein kinases: safeguarding genome integrity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3753707
retrieved
6 September 2017
MDC1 is a mediator of the mammalian DNA damage checkpoint
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3753707
retrieved
6 September 2017
DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3753707
retrieved
6 September 2017
ATR Regulates Fragile Site Stability
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3753707
retrieved
6 September 2017
DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3753707
retrieved
6 September 2017
53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3753707
retrieved
6 September 2017
53BP1, a mediator of the DNA damage checkpoint
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3753707
retrieved
6 September 2017
ATR and ATRIP: partners in checkpoint signaling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3753707
retrieved
6 September 2017
Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3753707
retrieved
6 September 2017
The DNA damage response: putting checkpoints in perspective
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3753707
retrieved
6 September 2017
Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3753707
retrieved
6 September 2017
Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3753707
retrieved
6 September 2017
ATR disruption leads to chromosomal fragmentation and early embryonic lethality
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3753707
retrieved
6 September 2017
Linkage of ATM to cell cycle regulation by the Chk2 protein kinase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3753707
retrieved
6 September 2017
Kruppel-associated Box (KRAB)-associated co-repressor (KAP-1) Ser-473 phosphorylation regulates heterochromatin protein 1β (HP1-β) mobilization and DNA repair in heterochromatin
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3753707
retrieved
6 September 2017
Targeting radiation-resistant hypoxic tumour cells through ATR inhibition
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3753707
retrieved
6 September 2017
53BP1 promotes ATM activity through direct interactions with the MRN complex
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3753707
retrieved
6 September 2017
Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3753707
retrieved
6 September 2017
Selective killing of ATM- or p53-deficient cancer cells through inhibition of ATR.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3753707
retrieved
14 September 2017
ATM-dependent and -independent dynamics of the nuclear phosphoproteome after DNA damage
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3753707
retrieved
14 September 2017
CtIP links DNA double-strand break sensing to resection
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3753707
retrieved
14 September 2017
The SUMO modification pathway is involved in the BRCA1 response to genotoxic stress.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3753707
retrieved
14 September 2017
CCDC98 is a BRCA1-BRCT domain-binding protein involved in the DNA damage response
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3753707
retrieved
14 September 2017
The Rad9-Hus1-Rad1 (9-1-1) clamp activates checkpoint signaling via TopBP1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3753707
retrieved
14 September 2017
Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3753707
retrieved
14 September 2017
The carboxy terminus of NBS1 is required for induction of apoptosis by the MRE11 complex
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3753707
retrieved
14 September 2017
ATR affecting cell radiosensitivity is dependent on homologous recombination repair but independent of nonhomologous end joining
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3753707
retrieved
14 September 2017
Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3753707
retrieved
28 September 2017
Chk1 activation requires Rad9 S/TQ-site phosphorylation to promote association with C-terminal BRCT domains of Rad4TOPBP1
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3753707
retrieved
28 September 2017
Histone H3 methylation links DNA damage detection to activation of the tumour suppressor Tip60.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3753707
retrieved
23 June 2018
Single-stranded DNA orchestrates an ATM-to-ATR switch at DNA breaks
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3753707
retrieved
23 June 2018
Recruitment of ATR to sites of ionising radiation-induced DNA damage requires ATM and components of the MRN protein complex
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3753707
retrieved
23 June 2018
ATRIP oligomerization is required for ATR-dependent checkpoint signaling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3753707
retrieved
23 June 2018
Discovery of potent and selective inhibitors of ataxia telangiectasia mutated and Rad3 related (ATR) protein kinase as potential anticancer agents.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3753707
retrieved
31 August 2018
ATR and H2AX cooperate in maintaining genome stability under replication stress
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3753707
retrieved
31 August 2018
HP1-beta mobilization promotes chromatin changes that initiate the DNA damage response.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3753707
retrieved
31 August 2018
The Rad9-Hus1-Rad1 checkpoint clamp regulates interaction of TopBP1 with ATR.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3753707
retrieved
31 August 2018
Ataxia-telangiectasia mutated (ATM)-dependent activation of ATR occurs through phosphorylation of TopBP1 by ATM.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3753707
retrieved
31 August 2018
Two-step activation of ATM by DNA and the Mre11-Rad50-Nbs1 complex.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3753707
retrieved
31 August 2018
Structure of the BRCT repeat domain of MDC1 and its specificity for the free COOH-terminal end of the gamma-H2AX histone tail
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3753707
retrieved
31 August 2018
Three-dimensional structure and regulation of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs).
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3753707
retrieved
31 August 2018
The ATRs, ATMs, and TORs are giant HEAT repeat proteins.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3753707
retrieved
31 August 2018
Electron microscopy and 3D reconstructions reveal that human ATM kinase uses an arm-like domain to clamp around double-stranded DNA
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24003211
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Multiple Mechanisms Control Chromosome Integrity after Replication Fork Uncoupling and Restart at Irreparable UV Lesions
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24003211
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Autophosphorylation at serine 1987 is dispensable for murine Atm activation in vivo
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24003211
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1101/CSHPERSPECT.A012716
1 reference
stated in
Europe PubMed Central
PMCID
3753707
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24003211%20AND%20SRC:MED&resulttype=core&format=json
retrieved
19 February 2020
PMCID
3753707
1 reference
stated in
Europe PubMed Central
PMCID
3753707
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24003211%20AND%20SRC:MED&resulttype=core&format=json
retrieved
19 February 2020
PubMed ID
24003211
1 reference
stated in
Europe PubMed Central
PMCID
3753707
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24003211%20AND%20SRC:MED&resulttype=core&format=json
retrieved
19 February 2020
ResearchGate publication ID
256425699
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