(Q46763707)

5 March 2018

title

Glucose Catabolism in Liver Tumors Induced by c-MYC Can Be Sustained by Various PKM1/PKM2 Ratios and Pyruvate Kinase Activities (English)

1 reference

5 March 2018

author name string

Andrés Méndez-Lucas

1

1 reference

5 March 2018

Xiaolei Li

2

1 reference

5 March 2018

Junjie Hu

3

1 reference

5 March 2018

Li Che

4

1 reference

5 March 2018

Xinhua Song

5

1 reference

5 March 2018

Jiaoyuan Jia

6

1 reference

5 March 2018

Jingxiao Wang

7

1 reference

5 March 2018

Chencheng Xie

8

1 reference

5 March 2018

Paul C Driscoll

9

1 reference

5 March 2018

Darjus F Tschaharganeh

10

1 reference

5 March 2018

Diego F Calvisi

11

1 reference

5 March 2018

Mariia Yuneva

12

1 reference

5 March 2018

Xin Chen

13

1 reference

5 March 2018

language of work or name

English

0 references

publication date

19 June 2017

1 reference

5 March 2018

published in

Cancer Research

1 reference

5 March 2018

volume

77

1 reference

5 March 2018

issue

16

1 reference

5 March 2018

page(s)

4355-4364

1 reference

5 March 2018

Germline loss of PKM2 promotes metabolic distress and hepatocellular carcinoma

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Lack of Evidence for PKM2 Protein Kinase Activity

24 May 2018

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24 May 2018

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Distinct anti-oncogenic effect of various microRNAs in different mouse models of liver cancer

24 May 2018

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1 December 2018

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12 December 2020

based on heuristic

Pyruvate kinase isoform expression alters nucleotide synthesis to impact cell proliferation

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5559320

PKM2 phosphorylates MLC2 and regulates cytokinesis of tumour cells.

24 May 2018

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Simultaneous targeting of PI3Kδ and a PI3Kδ-dependent MEK1/2-Erk1/2 pathway for therapy in pediatric B-cell acute lymphoblastic leukemia

24 May 2018

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p53-dependent Nestin regulation links tumor suppression to cellular plasticity in liver cancer

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5559320

PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells.

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5559320

Mitochondrial metabolism of sexual and asexual blood stages of the malaria parasite Plasmodium falciparum

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5559320

Reciprocal regulation of protein kinase and pyruvate kinase activities of pyruvate kinase M2 by growth signals

24 May 2018

1 reference

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M2 isoform of pyruvate kinase is dispensable for tumor maintenance and growth

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5559320

Serine is a natural ligand and allosteric activator of pyruvate kinase M2

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5559320

Small Molecule Activation of PKM2 in Cancer Cells Induces Serine Auxotrophy

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5559320

Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5559320

Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation.

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5559320

Oncogene-specific formation of chemoresistant murine hepatic cancer stem cells

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5559320

The metabolic profile of tumors depends on both the responsible genetic lesion and tissue type.

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5559320

Investigating tumor perfusion and metabolism using multiple hyperpolarized (13)C compounds: HP001, pyruvate and urea

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5559320

Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5559320

Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5559320

No evidence for a shift in pyruvate kinase PKM1 to PKM2 expression during tumorigenesis

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5559320

13C-pyruvate imaging reveals alterations in glycolysis that precede c-Myc-induced tumor formation and regression

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5559320

Stable isotope resolved metabolomics of lung cancer in a SCID mouse model

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5559320

Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5559320

Hallmarks of Cancer: The Next Generation

24 May 2018

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MYC phosphorylation, activation, and tumorigenic potential in hepatocellular carcinoma are regulated by HMG-CoA reductase

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5559320

Increased lipogenesis, induced by AKT-mTORC1-RPS6 signaling, promotes development of human hepatocellular carcinoma.

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5559320

Evidence for an alternative glycolytic pathway in rapidly proliferating cells

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5559320

Synergistic role of sprouty2 inactivation and c-Met up-regulation in mouse and human hepatocarcinogenesis

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5559320

Pyruvate kinase type M2: a key regulator of the metabolic budget system in tumor cells

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5559320

HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5559320

Central role of c-Myc during malignant conversion in human hepatocarcinogenesis

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5559320

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5559320

Pyruvate kinase M2 is a phosphotyrosine-binding protein

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5559320

MYC inactivation uncovers pluripotent differentiation and tumour dormancy in hepatocellular cancer

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5559320

Developmental context determines latency of MYC-induced tumorigenesis

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5559320

L- and M2-pyruvate kinase expression in renal cell carcinomas and their metastases

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5559320

The L- and R-type isozymes of rat pyruvate kinase are produced from a single gene by use of different promoters.

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5559320

In vivo regulation of monomer-tetramer conversion of pyruvate kinase subtype M2 by glucose is mediated via fructose 1,6-bisphosphate

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5559320

Double role for pyruvate kinase type M2 in the expansion of phosphometabolite pools found in tumor cells.

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5559320

(13)C-based metabolic flux analysis.

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5559320

Pyruvate kinase isoenzyme shift from L-type to M2-type is a late event in hepatocarcinogenesis induced in rats by a choline-deficient/DL-ethionine-supplemented diet.

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5559320

One gene, but two messenger RNAs encode liver L and red cell L′ pyruvate kinase subunits

15 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28630053

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Conversion of non-allosteric pyruvate kinase isozyme into an allosteric enzyme by a single amino acid substitution

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28630053

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1158/0008-5472.CAN-17-0498

1 reference

5 March 2018

PMC publication ID

5559320

1 reference

5 March 2018

PubMed publication ID

28630053

1 reference

5 March 2018