(Q46778500)

English

Alteration of mTOR signaling occurs early in the progression of Alzheimer disease (AD): analysis of brain from subjects with pre-clinical AD, amnestic mild cognitive impairment and late-stage AD.

scientific article published on 26 February 2015

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scholarly article

1 reference

Europe PubMed Central

25 December 2017

http://europepmc.org/abstract/MED/25645581

Alteration of mTOR signaling occurs early in the progression of Alzheimer disease (AD): analysis of brain from subjects with pre-clinical AD, amnestic mild cognitive impairment and late-stage AD. (English)

1 reference

Europe PubMed Central

25 December 2017

http://europepmc.org/abstract/MED/25645581

Alzheimer's disease

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mild cognitive impairment

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based on heuristic

inferred from title

cognitive dysfunction

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based on heuristic

inferred from title

Fabio Di Domenico

3

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Europe PubMed Central

25 December 2017

http://europepmc.org/abstract/MED/25645581

Raffaella Coccia

6

1 reference

Europe PubMed Central

25 December 2017

http://europepmc.org/abstract/MED/25645581

D Allan Butterfield

8

object named as

D Allan Butterfield

1 reference

Europe PubMed Central

25 December 2017

author name string

Antonella Tramutola

1

1 reference

Europe PubMed Central

25 December 2017

http://europepmc.org/abstract/MED/25645581

Judy C Triplett

2

1 reference

Europe PubMed Central

25 December 2017

http://europepmc.org/abstract/MED/25645581

Dana M Niedowicz

4

1 reference

Europe PubMed Central

25 December 2017

http://europepmc.org/abstract/MED/25645581

Michael P Murphy

5

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Europe PubMed Central

25 December 2017

http://europepmc.org/abstract/MED/25645581

Marzia Perluigi

7

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Europe PubMed Central

25 December 2017

http://europepmc.org/abstract/MED/25645581

language of work or name

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publication date

26 February 2015

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Europe PubMed Central

25 December 2017

http://europepmc.org/abstract/MED/25645581

Journal of Neurochemistry

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Europe PubMed Central

25 December 2017

http://europepmc.org/abstract/MED/25645581

133

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25 December 2017

http://europepmc.org/abstract/MED/25645581

5

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Europe PubMed Central

25 December 2017

http://europepmc.org/abstract/MED/25645581

739-749

1 reference

Europe PubMed Central

25 December 2017

http://europepmc.org/abstract/MED/25645581

Preclinical Alzheimer disease: brain oxidative stress, Abeta peptide and proteomics

1 reference

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21 January 2018

Up-regulation of phosphorylated/activated p70 S6 kinase and its relationship to neurofibrillary pathology in Alzheimer's disease

1 reference

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21 January 2018

PS1 activates PI3K thus inhibiting GSK-3 activity and tau overphosphorylation: effects of FAD mutations

1 reference

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21 January 2018

The PI3K-Akt-mTOR pathway regulates Abeta oligomer induced neuronal cell cycle events

1 reference

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Glycogen synthase kinase 3: a drug target for CNS therapies

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Phosphorylation of IRS proteins, insulin action, and insulin resistance

1 reference

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Increased levels of 4-hydroxynonenal and acrolein in the brain in preclinical Alzheimer disease

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Evidence of oxidative damage in Alzheimer's disease brain: central role for amyloid beta-peptide

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Redox proteomics analysis to decipher the neurobiology of Alzheimer-like neurodegeneration: overlaps in Down's syndrome and Alzheimer's disease brain.

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Elevated risk of type 2 diabetes for development of Alzheimer disease: a key role for oxidative stress in brain

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Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and Tau: effects on cognitive impairments

1 reference

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Association between frontal cortex oxidative damage and beta-amyloid as a function of age in Down syndrome

1 reference

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An investigation of the molecular mechanisms engaged before and after the development of Alzheimer disease neuropathology in Down syndrome: a proteomics approach

1 reference

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Phosphorylation of mammalian target of rapamycin (mTOR) at Ser-2448 is mediated by p70S6 kinase

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13037

21 January 2018

Insulin resistance syndrome and Alzheimer's disease: age- and obesity-related effects on memory, amyloid, and inflammation

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13037

21 January 2018

Alzheimer disease: Insulin resistance and AD--extending the translational path.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13037

21 January 2018

Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Abeta oligomers

1 reference

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21 January 2018

Brain insulin resistance and deficiency as therapeutic targets in Alzheimer's disease

1 reference

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21 January 2018

Impairment of proteostasis network in Down syndrome prior to the development of Alzheimer's disease neuropathology: redox proteomics analysis of human brain.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13037

21 January 2018

Antisense oligonucleotide against GSK-3β in brain of SAMP8 mice improves learning and memory and decreases oxidative stress: Involvement of transcription factor Nrf2 and implications for Alzheimer disease

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13037

21 January 2018

Activation of Akt/PKB, increased phosphorylation of Akt substrates and loss and altered distribution of Akt and PTEN are features of Alzheimer's disease pathology

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13037

21 January 2018

PTEN, a widely known negative regulator of insulin/PI3K signaling, positively regulates neuronal insulin resistance

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13037

21 January 2018

Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13037

21 January 2018

Alzheimer's disease: the challenge of the second century

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13037

21 January 2018

Insulin and insulin-like growth factor-1 regulate tau phosphorylation in cultured human neurons.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13037

21 January 2018

Neuronal hypertrophy in asymptomatic Alzheimer disease

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13037

21 January 2018

PTEN: The down side of PI 3-kinase signalling.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13037

21 January 2018

Inhibition of PI-3 kinase/Akt/mTOR, but not calcineurin signaling, reverses insulin-like growth factor I-induced protection against glucose toxicity in cardiomyocyte contractile function

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13037

21 January 2018

Levels of mTOR and its downstream targets 4E-BP1, eEF2, and eEF2 kinase in relationships with tau in Alzheimer's disease brain

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13037

21 January 2018

A central role for autophagy in Alzheimer-type neurodegeneration

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13037

21 January 2018

Alterations of zinc transporter proteins ZnT-1, ZnT-4 and ZnT-6 in preclinical Alzheimer's disease brain

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13037

21 January 2018

Inducing autophagy by rapamycin before, but not after, the formation of plaques and tangles ameliorates cognitive deficits

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13037

21 January 2018

The rapamycin-binding domain governs substrate selectivity by the mammalian target of rapamycin

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13037

21 January 2018

Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13037

21 January 2018

The role of autophagy in neurodegenerative disease

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13037

21 January 2018

Insulin and IGF-1 signalling: longevity, protein homoeostasis and Alzheimer's disease.

1 reference

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21 January 2018

Neuropathological role of PI3K/Akt/mTOR axis in Down syndrome brain.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13037

21 January 2018

Mild cognitive impairment as a diagnostic entity

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13037

21 January 2018

Alzheimer's Disease

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13037

21 January 2018

Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13037

21 January 2018

Soluble Abeta inhibits specific signal transduction cascades common to the insulin receptor pathway.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13037

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Hippocampal neurons in pre-clinical Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13037

21 January 2018

Dysfunction of the mTOR pathway is a risk factor for Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13037

21 January 2018

Insulin resistance and amyloidogenesis as common molecular foundation for type 2 diabetes and Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13037

21 January 2018

Identifiers

10.1111/JNC.13037

1 reference

Europe PubMed Central

25 December 2017

http://europepmc.org/abstract/MED/25645581

1 reference

Europe PubMed Central

25 December 2017

http://europepmc.org/abstract/MED/25645581

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