(Q46869125)

English

In vitro characterization of the human biotransformation and CYP reaction phenotype of ET-743 (Yondelis, Trabectidin), a novel marine anti-cancer drug

scientific article published in January 2006

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

26 December 2017

http://europepmc.org/abstract/MED/16379042

In vitro characterization of the human biotransformation and CYP reaction phenotype of ET-743 (Yondelis, Trabectidin), a novel marine anti-cancer drug (English)

1 reference

Europe PubMed Central

PubMed publication ID

26 December 2017

http://europepmc.org/abstract/MED/16379042

6

object named as

Jos H Beijnen

1 reference

Europe PubMed Central

PubMed publication ID

26 December 2017

http://europepmc.org/abstract/MED/16379042

Jan H M Schellens

7

object named as

Jan H M Schellens

1 reference

Europe PubMed Central

PubMed publication ID

26 December 2017

http://europepmc.org/abstract/MED/16379042

author name string

Esther F A Brandon

1

1 reference

Europe PubMed Central

PubMed publication ID

26 December 2017

http://europepmc.org/abstract/MED/16379042

Rolf W Sparidans

2

1 reference

Europe PubMed Central

PubMed publication ID

26 December 2017

http://europepmc.org/abstract/MED/16379042

Kees-Jan Guijt

3

1 reference

Europe PubMed Central

PubMed publication ID

26 December 2017

http://europepmc.org/abstract/MED/16379042

Sjoerd Löwenthal

4

1 reference

Europe PubMed Central

PubMed publication ID

26 December 2017

http://europepmc.org/abstract/MED/16379042

Irma Meijerman

5

1 reference

Europe PubMed Central

PubMed publication ID

26 December 2017

http://europepmc.org/abstract/MED/16379042

publication date

1 January 2006

1 reference

Europe PubMed Central

PubMed publication ID

26 December 2017

http://europepmc.org/abstract/MED/16379042

Investigational New Drugs

1 reference

Europe PubMed Central

PubMed publication ID

26 December 2017

http://europepmc.org/abstract/MED/16379042

24

1 reference

Europe PubMed Central

PubMed publication ID

26 December 2017

http://europepmc.org/abstract/MED/16379042

1

1 reference

Europe PubMed Central

PubMed publication ID

26 December 2017

http://europepmc.org/abstract/MED/16379042

3-14

1 reference

Europe PubMed Central

PubMed publication ID

26 December 2017

http://europepmc.org/abstract/MED/16379042

https://scigraph.springernature.com/pub.10.1007/s10637-005-4538-9

0 references

Human liver microsomal metabolism of paclitaxel and drug interactions

1 reference

https://api.crossref.org/works/10.1007%2FS10637-005-4538-9

21 January 2018

Integrated cytochrome P450 reaction phenotyping: attempting to bridge the gap between cDNA-expressed cytochromes P450 and native human liver microsomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/16379042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gender-related differences in pharmacokinetics and their clinical significance

1 reference

https://pubmed.ncbi.nlm.nih.gov/16379042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple cytochrome P450 enzymes responsible for the oxidative metabolism of the substituted (S)-3-phenylpiperidine, (S,S)-3-[3-(methylsulfonyl)phenyl]-1-propylpiperidine hydrochloride, in human liver microsomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/16379042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison between cytochrome P450 (CYP) content and relative activity approaches to scaling from cDNA-expressed CYPs to human liver microsomes: ratios of accessory proteins as sources of discrepancies between the approaches.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16379042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rat and human liver cytochrome P-450 isoform metabolism of ecteinascidin 743 does not predict gender-dependent toxicity in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/16379042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic polymorphisms of human N-acetyltransferase, cytochrome P450, glutathione-S-transferase, and epoxide hydrolase enzymes: relevance to xenobiotic metabolism and toxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/16379042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A clinical armamentarium of marine-derived anti-cancer compounds

1 reference

https://pubmed.ncbi.nlm.nih.gov/16379042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An update on in vitro test methods in human hepatic drug biotransformation research: pros and cons

1 reference

https://pubmed.ncbi.nlm.nih.gov/16379042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Preclinical and clinical results with the natural marine product ET-743

1 reference

https://pubmed.ncbi.nlm.nih.gov/16379042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The rational selection of drug interaction studies: implications of recent advances in drug metabolism.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16379042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The use of heterologously expressed drug metabolizing enzymes--state of the art and prospects for the future

1 reference

https://pubmed.ncbi.nlm.nih.gov/16379042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Potent inhibition of the cytochrome P-450 3A-mediated human liver microsomal metabolism of a novel HIV protease inhibitor by ritonavir: A positive drug-drug interaction

1 reference

https://pubmed.ncbi.nlm.nih.gov/16379042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics of ecteinascidin 743 administered as a 24-h continuous intravenous infusion to adult patients with soft tissue sarcomas: associations with clinical characteristics, pathophysiological variables and toxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/16379042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CYP3A5 variant allele frequencies in Dutch Caucasians

1 reference

https://pubmed.ncbi.nlm.nih.gov/16379042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Yondelis (trabectedin, ET-743): the development of an anticancer agent of marine origin

1 reference

https://pubmed.ncbi.nlm.nih.gov/16379042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition and induction of cytochrome P450 and the clinical implications

1 reference

https://pubmed.ncbi.nlm.nih.gov/16379042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The use of in vitro methods to predict in vivo pharmacokinetics and drug interactions

1 reference

https://pubmed.ncbi.nlm.nih.gov/16379042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro inhibition of the cytochrome P450 (CYP450) system by the antiplatelet drug ticlopidine: potent effect on CYP2C19 and CYP2D6

1 reference

https://pubmed.ncbi.nlm.nih.gov/16379042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison of four modulators of drug metabolism as protectants against the hepatotoxicity of the novel antitumor drug yondelis (ET-743) in the female rat and in hepatocytes in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/16379042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Polymorphisms in UDP glucuronosyltransferase genes: functional consequences and clinical relevance.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16379042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Search for metabolites of ecteinascidin 743, a novel, marine-derived, anti-cancer agent, in man.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16379042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ecteinascidin 743: a novel anticancer drug with a unique mechanism of action

1 reference

https://pubmed.ncbi.nlm.nih.gov/16379042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification and functional characterization of eight CYP3A4 protein variants

1 reference

https://pubmed.ncbi.nlm.nih.gov/16379042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Scaling drug biotransformation data from cDNA-expressed cytochrome P-450 to human liver: a comparison of relative activity factors and human liver abundance in studies of mirtazapine metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/16379042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics and pharmacodynamics of the novel marine-derived anticancer agent ecteinascidin 743 in a phase I dose-finding study.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16379042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The prediction of human pharmacokinetic parameters from preclinical and in vitro metabolism data.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16379042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytochrome P450 in vitro reaction phenotyping: a re-evaluation of approaches used for P450 isoform identification

1 reference

https://pubmed.ncbi.nlm.nih.gov/16379042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase II study of ecteinascidin 743 in heavily pretreated patients with recurrent osteosarcoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/16379042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytochrome p450 phenotyping/genotyping in patients receiving antipsychotics: useful aid to prescribing?

1 reference

https://pubmed.ncbi.nlm.nih.gov/16379042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sense and nonsense in the prediction of drug-drug interactions

1 reference

https://pubmed.ncbi.nlm.nih.gov/16379042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of the human liver cytochrome P450 isoenzyme responsible for the 6-methylhydroxylation of the novel anticancer drug 5,6-dimethylxanthenone-4-acetic acid

1 reference

https://pubmed.ncbi.nlm.nih.gov/16379042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dietary agent indole-3-carbinol protects female rats against the hepatotoxicity of the antitumor drug ET-743 (trabectidin) without compromising efficacy in a rat mammary carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/16379042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Unique features of the mode of action of ET-743.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16379042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S10637-005-4538-9

1 reference

Europe PubMed Central

PubMed publication ID

26 December 2017

http://europepmc.org/abstract/MED/16379042

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

26 December 2017

http://europepmc.org/abstract/MED/16379042

ResearchGate publication ID

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