(Q46876545)

26 December 2017

http://europepmc.org/abstract/MED/18045910

title

The Down syndrome critical region protein RCAN1 regulates long-term potentiation and memory via inhibition of phosphatase signaling (English)

1 reference

26 December 2017

http://europepmc.org/abstract/MED/18045910

main subject

long-term potentiation

1 reference

1 reference

7

James A Richardson

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6673398&resulttype=core&format=json

16 May 2020

author name string

Charles A Hoeffer

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6673398&resulttype=core&format=json

16 May 2020

Asim Dey

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6673398&resulttype=core&format=json

16 May 2020

Nita Sachan

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6673398&resulttype=core&format=json

16 May 2020

Helen Wong

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6673398&resulttype=core&format=json

16 May 2020

Richard J Patterson

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6673398&resulttype=core&format=json

16 May 2020

John M Shelton

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6673398&resulttype=core&format=json

16 May 2020

Eric Klann

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6673398&resulttype=core&format=json

16 May 2020

Beverly A Rothermel

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6673398&resulttype=core&format=json

16 May 2020

language of work or name

English

0 references

publication date

1 November 2007

1 reference

26 December 2017

http://europepmc.org/abstract/MED/18045910

published in

Journal of Neuroscience

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6673398&resulttype=core&format=json

16 May 2020

volume

27

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6673398&resulttype=core&format=json

16 May 2020

issue

48

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6673398&resulttype=core&format=json

16 May 2020

page(s)

13161-13172

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6673398&resulttype=core&format=json

describes a project that uses

16 May 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC6673398/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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12 December 2020

Long-lasting forms of synaptic potentiation in the mammalian hippocampus

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DSCR1, overexpressed in Down syndrome, is an inhibitor of calcineurin-mediated signaling pathways

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Antisense DNA against calcineurin facilitates memory in contextual fear conditioning by lowering the threshold for hippocampal long-term potentiation induction.

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12 December 2020

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12 December 2020

Inducible and reversible enhancement of learning, memory, and long-term potentiation by genetic inhibition of calcineurin.

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12 December 2020

Roles of serine/threonine phosphatases in hippocampal synaptic plasticity.

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12 December 2020

Chronic overexpression of the calcineurin inhibitory gene DSCR1 (Adapt78) is associated with Alzheimer's disease

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12 December 2020

Forebrain-specific calcineurin knockout selectively impairs bidirectional synaptic plasticity and working/episodic-like memory

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Dual roles of modulatory calcineurin-interacting protein 1 in cardiac hypertrophy

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The role of modulatory calcineurin-interacting proteins in calcineurin signaling

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Conditional calcineurin knockout mice exhibit multiple abnormal behaviors related to schizophrenia

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The threshold pattern of calcineurin-dependent gene expression is altered by loss of the endogenous inhibitor calcipressin

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Calcineurin in memory and bidirectional plasticity

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Critical role of calpain-mediated cleavage of calcineurin in excitotoxic neurodegeneration.

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The Drosophila homolog of Down's syndrome critical region 1 gene regulates learning: implications for mental retardation.

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GSK-3 kinases enhance calcineurin signaling by phosphorylation of RCNs

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A small molecular activator of cardiac hypertrophy uncovered in a chemical screen for modifiers of the calcineurin signaling pathway

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12 December 2020

Mitochondria, synaptic plasticity, and schizophrenia

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12 December 2020

Calcineurin triggers reactive/inflammatory processes in astrocytes and is upregulated in aging and Alzheimer's models

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12 December 2020

Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning

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12 December 2020

Truncation and activation of calcineurin A by calpain I in Alzheimer disease brain

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12 December 2020

Calcineurin-binding protein Cbp1 directs the specificity of calcineurin-dependent hyphal elongation during mating in Cryptococcus neoformans

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12 December 2020

Drosophila melanogaster homolog of Down syndrome critical region 1 is critical for mitochondrial function

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12 December 2020

Alzheimer's disease and endocytic dysfunction: clues from the Down syndrome-related proteins, DSCR1 and ITSN1

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12 December 2020

A genome-wide Drosophila RNAi screen identifies DYRK-family kinases as regulators of NFAT

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12 December 2020

Modulatory calcineurin-interacting proteins 1 and 2 function as calcineurin facilitators in vivo

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12 December 2020

Generation of constitutively active calcineurin by calpain contributes to delayed neuronal death following mouse brain ischemia.

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Cooperation to amplify gene-dosage-imbalance effects.

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12 December 2020

BCL-xL regulates synaptic plasticity

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12 December 2020

Mitochondrial regulation of neuronal plasticity

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12 December 2020

RCAN1-1L is overexpressed in neurons of Alzheimer's disease patients

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12 December 2020

The mitochondrial permeability transition in neurologic disease

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12 December 2020

Acute inhibition of calcineurin restores associative learning and memory in Tg2576 APP transgenic mice

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12 December 2020

Differential expression of members of the RCAN family of calcineurin regulators suggests selective functions for these proteins in the brain

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12 December 2020

The role of calcium in neuromuscular facilitation

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12 December 2020

DARPP-32, a dopamine-regulated neuronal phosphoprotein, is a potent inhibitor of protein phosphatase-1

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12 December 2020

Developments of a water-maze procedure for studying spatial learning in the rat

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12 December 2020

Inhibition of phosphatase 2B prevents expression of hippocampal long-term potentiation

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12 December 2020

Alzheimer's disease abnormally phosphorylated tau is dephosphorylated by protein phosphatase-2B (calcineurin).

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12 December 2020

FK506, a Ca2+/calmodulin-dependent phosphatase inhibitor, inhibits the induction of long-term potentiation in the rat hippocampus.

1 reference

12 December 2020

Genetic demonstration of a role for PKA in the late phase of LTP and in hippocampus-based long-term memory

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12 December 2020

Suppression of signalling through transcription factor NF-AT by interactions between calcineurin and Bcl-2.

1 reference

12 December 2020

Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription

1 reference

12 December 2020

Genomic organization, alternative splicing, and expression patterns of the DSCR1 (Down syndrome candidate region 1) gene

1 reference

12 December 2020

Attenuation of paired-pulse facilitation associated with synaptic potentiation mediated by postsynaptic mechanisms

1 reference

12 December 2020

Genetic and pharmacological evidence for a novel, intermediate phase of long-term potentiation suppressed by calcineurin.

1 reference

12 December 2020

Restricted and regulated overexpression reveals calcineurin as a key component in the transition from short-term to long-term memory.

1 reference

12 December 2020

Regulation of the calmodulin-stimulated protein phosphatase, calcineurin

1 reference

12 December 2020

Inducible and reversible gene expression with the rtTA system for the study of memory.

1 reference

12 December 2020

A dopamine/D1 receptor/protein kinase A/dopamine- and cAMP-regulated phosphoprotein (Mr 32 kDa)/protein phosphatase-1 pathway regulates dephosphorylation of the NMDA receptor.

1 reference

12 December 2020

10.1523/JNEUROSCI.3974-07.2007

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6673398&resulttype=core&format=json

16 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6673398&resulttype=core&format=json

16 May 2020

1 reference