(Q46892881)

English

Kinase MEKK1 is required for CD40-dependent activation of the kinases Jnk and p38, germinal center formation, B cell proliferation and antibody production

scientific article published on 3 December 2006

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

26 December 2017

http://europepmc.org/abstract/MED/17143273

Kinase MEKK1 is required for CD40-dependent activation of the kinases Jnk and p38, germinal center formation, B cell proliferation and antibody production (English)

1 reference

Europe PubMed Central

PubMed publication ID

26 December 2017

http://europepmc.org/abstract/MED/17143273

1 reference

based on heuristic

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9

object named as

Michael Karin

1 reference

Europe PubMed Central

PubMed publication ID

26 December 2017

author name string

Ewen Gallagher

1

1 reference

Europe PubMed Central

PubMed publication ID

26 December 2017

http://europepmc.org/abstract/MED/17143273

Thomas Enzler

2

1 reference

Europe PubMed Central

PubMed publication ID

26 December 2017

http://europepmc.org/abstract/MED/17143273

Atsushi Matsuzawa

3

1 reference

Europe PubMed Central

PubMed publication ID

26 December 2017

http://europepmc.org/abstract/MED/17143273

Amy Anzelon-Mills

4

1 reference

Europe PubMed Central

PubMed publication ID

26 December 2017

http://europepmc.org/abstract/MED/17143273

Dennis Otero

5

1 reference

Europe PubMed Central

PubMed publication ID

26 December 2017

http://europepmc.org/abstract/MED/17143273

Ryan Holzer

6

1 reference

Europe PubMed Central

PubMed publication ID

26 December 2017

http://europepmc.org/abstract/MED/17143273

Edith Janssen

7

1 reference

Europe PubMed Central

PubMed publication ID

26 December 2017

http://europepmc.org/abstract/MED/17143273

Min Gao

8

1 reference

Europe PubMed Central

PubMed publication ID

26 December 2017

http://europepmc.org/abstract/MED/17143273

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publication date

3 December 2006

1 reference

Europe PubMed Central

PubMed publication ID

26 December 2017

http://europepmc.org/abstract/MED/17143273

Nature Immunology

1 reference

Europe PubMed Central

PubMed publication ID

26 December 2017

http://europepmc.org/abstract/MED/17143273

8

1 reference

Europe PubMed Central

PubMed publication ID

26 December 2017

http://europepmc.org/abstract/MED/17143273

1

1 reference

Europe PubMed Central

PubMed publication ID

26 December 2017

http://europepmc.org/abstract/MED/17143273

57-63

1 reference

Europe PubMed Central

PubMed publication ID

26 December 2017

http://europepmc.org/abstract/MED/17143273

Mammalian MAP kinase signalling cascades

1 reference

https://api.crossref.org/works/10.1038%2FNI1421

7 January 2021

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MAP kinases in the immune response

1 reference

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7 January 2021

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Raf kinases: oncogenesis and drug discovery

1 reference

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7 January 2021

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Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK

1 reference

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7 January 2021

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A role for MEK kinase 1 in TGF-beta/activin-induced epithelium movement and embryonic eyelid closure

1 reference

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7 January 2021

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Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain

1 reference

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7 January 2021

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MEK kinase 1 is critically required for c-Jun N-terminal kinase activation by proinflammatory stimuli and growth factor-induced cell migration.

1 reference

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Jun turnover is controlled through JNK-dependent phosphorylation of the E3 ligase Itch

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Dysregulation of T lymphocyte function in itchy mice: a role for Itch in TH2 differentiation.

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Th2 cell-specific cytokine expression and allergen-induced airway inflammation depend on JunB.

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7 January 2021

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TRAF2-mediated activation of NF-kappa B by TNF receptor 2 and CD40

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Tumor necrosis factor signaling to stress-activated protein kinase (SAPK)/Jun NH2-terminal kinase (JNK) and p38. Germinal center kinase couples TRAF2 to mitogen-activated protein kinase/ERK kinase kinase 1 and SAPK while receptor interacting [...]

1 reference

https://api.crossref.org/works/10.1038%2FNI1421

7 January 2021

based on heuristic

inferred from DOI database lookup

Ubiquitination and translocation of TRAF2 is required for activation of JNK but not of p38 or NF-kappaB.

1 reference

https://api.crossref.org/works/10.1038%2FNI1421

7 January 2021

based on heuristic

inferred from DOI database lookup

Ubiquitylation of MEKK1 inhibits its phosphorylation of MKK1 and MKK4 and activation of the ERK1/2 and JNK pathways

1 reference

https://api.crossref.org/works/10.1038%2FNI1421

7 January 2021

based on heuristic

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The PHD domain of MEKK1 acts as an E3 ubiquitin ligase and mediates ubiquitination and degradation of ERK1/2

1 reference

https://api.crossref.org/works/10.1038%2FNI1421

7 January 2021

based on heuristic

inferred from DOI database lookup

AP-1 as a regulator of cell life and death

1 reference

https://api.crossref.org/works/10.1038%2FNI1421

7 January 2021

based on heuristic

inferred from DOI database lookup

Cyclin D2 is essential for BCR-mediated proliferation and CD5 B cell development

1 reference

https://api.crossref.org/works/10.1038%2FNI1421

7 January 2021

based on heuristic

inferred from DOI database lookup

Cyclin D3 Compensates for Loss of Cyclin D2 in Mouse B-lymphocytes Activated via the Antigen Receptor and CD40

1 reference

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7 January 2021

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The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry

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https://api.crossref.org/works/10.1038%2FNI1421

7 January 2021

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The Fas death factor

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7 January 2021

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The binding site for TRAF2 and TRAF3 but not for TRAF6 is essential for CD40-mediated immunoglobulin class switching

1 reference

https://api.crossref.org/works/10.1038%2FNI1421

7 January 2021

based on heuristic

inferred from DOI database lookup

The CD40-TRAF6 axis controls affinity maturation and the generation of long-lived plasma cells

1 reference

https://api.crossref.org/works/10.1038%2FNI1421

7 January 2021

based on heuristic

inferred from DOI database lookup

Dissection of B cell differentiation during primary immune responses in mice with altered CD40 signals

1 reference

https://api.crossref.org/works/10.1038%2FNI1421

7 January 2021

based on heuristic

inferred from DOI database lookup

Tumor necrosis factor receptor-associated factor 2 (TRAF2)-deficient B lymphocytes reveal novel roles for TRAF2 in CD40 signaling

1 reference

https://api.crossref.org/works/10.1038%2FNI1421

7 January 2021

based on heuristic

inferred from DOI database lookup

An atypical tumor necrosis factor (TNF) receptor-associated factor-binding motif of B cell-activating factor belonging to the TNF family (BAFF) receptor mediates induction of the noncanonical NF-kappaB signaling pathway.

1 reference

https://api.crossref.org/works/10.1038%2FNI1421

7 January 2021

based on heuristic

inferred from DOI database lookup

The immune responses in CD40-deficient mice: impaired immunoglobulin class switching and germinal center formation

1 reference

https://api.crossref.org/works/10.1038%2FNI1421

7 January 2021

based on heuristic

inferred from DOI database lookup

NF-kappaB-mediated up-regulation of Bcl-x and Bfl-1/A1 is required for CD40 survival signaling in B lymphocytes

1 reference

https://api.crossref.org/works/10.1038%2FNI1421

7 January 2021

based on heuristic

inferred from DOI database lookup

Genetic dissection of antigen receptor induced-NF-kappaB activation

1 reference

https://api.crossref.org/works/10.1038%2FNI1421

7 January 2021

based on heuristic

inferred from DOI database lookup

The two NF-kappaB activation pathways and their role in innate and adaptive immunity

1 reference

https://api.crossref.org/works/10.1038%2FNI1421

7 January 2021

based on heuristic

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TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo

1 reference

https://api.crossref.org/works/10.1038%2FNI1421

7 January 2021

based on heuristic

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Essential function for the kinase TAK1 in innate and adaptive immune responses.

1 reference

https://api.crossref.org/works/10.1038%2FNI1421

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based on heuristic

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Regulating the regulators: control of protein ubiquitination and ubiquitin-like modifications by extracellular stimuli

1 reference

https://api.crossref.org/works/10.1038%2FNI1421

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based on heuristic

inferred from DOI database lookup

Binding of JNK/SAPK to MEKK1 is regulated by phosphorylation

1 reference

https://api.crossref.org/works/10.1038%2FNI1421

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based on heuristic

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Pten inactivation alters peripheral B lymphocyte fate and reconstitutes CD19 function

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Complement receptors CD21/35 link innate and protective immunity during Streptococcus pneumoniae infection by regulating IgG3 antibody responses

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Immunoglobulin class switching: in vitro induction and analysis

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Detection of individual mouse splenic T cells producing IFN-gamma and IL-5 using the enzyme-linked immunospot (ELISPOT) assay.

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Activation of IKKalpha target genes depends on recognition of specific kappaB binding sites by RelB:p52 dimers

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Characterization of B lymphopoiesis in mouse bone marrow and spleen

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Identifiers

1 reference

Europe PubMed Central

PubMed publication ID

26 December 2017

http://europepmc.org/abstract/MED/17143273

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

26 December 2017

http://europepmc.org/abstract/MED/17143273

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