(Q46930696)

English

Oncogenic Ras inhibits anoikis of intestinal epithelial cells by preventing the release of a mitochondrial pro-apoptotic protein Omi/HtrA2 into the cytoplasm

scientific article published on 3 February 2006

In more languages

Statements

scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

26 December 2017

http://europepmc.org/abstract/MED/16461771

Oncogenic Ras inhibits anoikis of intestinal epithelial cells by preventing the release of a mitochondrial pro-apoptotic protein Omi/HtrA2 into the cytoplasm (English)

1 reference

Europe PubMed Central

PubMed publication ID

26 December 2017

http://europepmc.org/abstract/MED/16461771

apoptotic process

1 reference

based on heuristic

inferred from title

author name string

Zaiping Liu

1

1 reference

Europe PubMed Central

PubMed publication ID

26 December 2017

http://europepmc.org/abstract/MED/16461771

Hongbing Li

2

1 reference

Europe PubMed Central

PubMed publication ID

26 December 2017

http://europepmc.org/abstract/MED/16461771

Mathieu Derouet

3

1 reference

Europe PubMed Central

PubMed publication ID

26 December 2017

http://europepmc.org/abstract/MED/16461771

Alexander Berezkin

4

1 reference

Europe PubMed Central

PubMed publication ID

26 December 2017

http://europepmc.org/abstract/MED/16461771

Takehiko Sasazuki

5

1 reference

Europe PubMed Central

PubMed publication ID

26 December 2017

http://europepmc.org/abstract/MED/16461771

Senji Shirasawa

6

1 reference

Europe PubMed Central

PubMed publication ID

26 December 2017

http://europepmc.org/abstract/MED/16461771

Kirill Rosen

7

1 reference

Europe PubMed Central

PubMed publication ID

26 December 2017

http://europepmc.org/abstract/MED/16461771

language of work or name

0 references

publication date

3 February 2006

1 reference

Europe PubMed Central

PubMed publication ID

26 December 2017

http://europepmc.org/abstract/MED/16461771

number of pages

10

1 reference

based on heuristic

inferred from page(s)

Journal of Biological Chemistry

1 reference

Europe PubMed Central

PubMed publication ID

26 December 2017

http://europepmc.org/abstract/MED/16461771

281

1 reference

Europe PubMed Central

PubMed publication ID

26 December 2017

http://europepmc.org/abstract/MED/16461771

21

1 reference

Europe PubMed Central

PubMed publication ID

26 December 2017

http://europepmc.org/abstract/MED/16461771

14738-14747

1 reference

Europe PubMed Central

PubMed publication ID

26 December 2017

http://europepmc.org/abstract/MED/16461771

Massive programmed cell death in intestinal epithelial cells induced by three-dimensional growth conditions: suppression by mutant c-H-ras oncogene expression

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508664200

21 January 2018

Matrix detachment induces caspase-dependent cytochrome c release from mitochondria: inhibition by PKB/Akt but not Raf signalling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508664200

21 January 2018

Disruption of epithelial cell-matrix interactions induces apoptosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508664200

21 January 2018

Anoikis mechanisms

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508664200

21 January 2018

The extracellular matrix as a cell survival factor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508664200

21 January 2018

Suppression of anoikis and induction of metastasis by the neurotrophic receptor TrkB

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508664200

21 January 2018

Taking the study of cancer cell survival to a new dimension

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508664200

21 January 2018

Integrins, adhesion and apoptosis.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508664200

21 January 2018

Increased expression of apoptosis inhibitor protein XIAP contributes to anoikis resistance of circulating human prostate cancer metastasis precursor cells.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508664200

21 January 2018

Downregulation of the pro-apoptotic protein Bak is required for the ras-induced transformation of intestinal epithelial cells.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508664200

21 January 2018

Oncogenic Ras blocks anoikis by activation of a novel effector pathway independent of phosphatidylinositol 3-kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508664200

21 January 2018

Understanding Ras: 'it ain't over 'til it's over'.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508664200

21 January 2018

Activated Ras prevents downregulation of Bcl-X(L) triggered by detachment from the extracellular matrix. A mechanism of Ras-induced resistance to anoikis in intestinal epithelial cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508664200

21 January 2018

Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508664200

21 January 2018

Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508664200

21 January 2018

Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508664200

21 January 2018

A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508664200

21 January 2018

HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508664200

21 January 2018

The mitochondrial ARTS protein promotes apoptosis through targeting XIAP

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508664200

21 January 2018

Mitochondria in apoptosis and human disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508664200

21 January 2018

Cell death regulation by the Bcl-2 protein family in the mitochondria

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508664200

21 January 2018

Caspases: intracellular signaling by proteolysis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508664200

21 January 2018

Identification of Omi/HtrA2 as a mitochondrial apoptotic serine protease that disrupts inhibitor of apoptosis protein-caspase interaction

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508664200

21 January 2018

The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a reaper-like motif

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508664200

21 January 2018

Bcl-2 inhibits the mitochondrial release of an apoptogenic protease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508664200

21 January 2018

Endonuclease G is an apoptotic DNase when released from mitochondria

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508664200

21 January 2018

The Bcl-2 protein family: arbiters of cell survival

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508664200

21 January 2018

Keeping killers on a tight leash: transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508664200

21 January 2018

FLICE is activated by association with the CD95 death-inducing signaling complex (DISC).

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508664200

21 January 2018

Molecular ordering of the initial signaling events of CD95.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508664200

21 January 2018

Evidence for a function of death-receptor-related, death-domain-containing proteins in anoikis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508664200

21 January 2018

Involvement of FADD and caspase-8 signalling in detachment-induced apoptosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508664200

21 January 2018

Regulation of Bcl-xL expression in human keratinocytes by cell-substratum adhesion and the epidermal growth factor receptor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508664200

21 January 2018

Cell detachment triggers p38 mitogen-activated protein kinase-dependent overexpression of Fas ligand. A novel mechanism of Anoikis of intestinal epithelial cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508664200

21 January 2018

A mitochondrial protein, Bit1, mediates apoptosis regulated by integrins and Groucho/TLE corepressors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508664200

21 January 2018

Functional role of death-associated protein 3 (DAP3) in anoikis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508664200

21 January 2018

Integrins and EGFR coordinately regulate the pro-apoptotic protein Bim to prevent anoikis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508664200

21 January 2018

Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508664200

21 January 2018

Integrin-mediated survival signals regulate the apoptotic function of Bax through its conformation and subcellular localization.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508664200

21 January 2018

Transforming growth factor-alpha prevents detachment-induced inhibition of c-Src kinase activity, Bcl-XL down-regulation, and apoptosis of intestinal epithelial cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508664200

21 January 2018

Increased Bcl-xL expression mediates v-Src-induced resistance to anoikis in intestinal epithelial cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508664200

21 January 2018

FLICE/caspase-8 activation triggers anoikis induced by beta1-integrin blockade in human keratinocytes.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508664200

21 January 2018

Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508664200

21 January 2018

Altered growth of human colon cancer cell lines disrupted at activated Ki-ras

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508664200

21 January 2018

Inhibitor of apoptosis proteins are substrates for the mitochondrial serine protease Omi/HtrA2

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508664200

21 January 2018

ras Oncogene triggers up-regulation of cIAP2 and XIAP in intestinal epithelial cells: epidermal growth factor receptor-dependent and -independent mechanisms of ras-induced transformation.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508664200

21 January 2018

A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508664200

21 January 2018

Chemotherapy-induced apoptosis of S-type neuroblastoma cells requires caspase-9 and is augmented by CD95/Fas stimulation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508664200

21 January 2018

Caspase 9 is required for p53-dependent apoptosis and chemosensitivity in a human ovarian cancer cell line

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508664200

21 January 2018

Omi/HtrA2 catalytic cleavage of inhibitor of apoptosis (IAP) irreversibly inactivates IAPs and facilitates caspase activity in apoptosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508664200

21 January 2018

Mechanisms of apoptosis induction by nucleoside analogs.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508664200

21 January 2018

Non-steroidal anti-inflammatory drugs and molecular carcinogenesis of colorectal carcinomas

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508664200

21 January 2018

Irinotecan: mechanisms of tumor resistance and novel strategies for modulating its activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508664200

21 January 2018

Mechanisms of cytochrome c release by proapoptotic BCL-2 family members

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508664200

21 January 2018

Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508664200

21 January 2018

Analysis of the transcriptional program induced by Raf in epithelial cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508664200

21 January 2018

Matrix-independent survival of human keratinocytes through an EGF receptor/MAPK-kinase-dependent pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508664200

21 January 2018

The serine protease Omi/HtrA2 is released from mitochondria during apoptosis. Omi interacts with caspase-inhibitor XIAP and induces enhanced caspase activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508664200

21 January 2018

Apaf-1 and caspase-9 accelerate apoptosis, but do not determine whether factor-deprived or drug-treated cells die

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508664200

21 January 2018

Apoptosis-associated release of Smac/DIABLO from mitochondria requires active caspases and is blocked by Bcl-2

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508664200

21 January 2018

IAP family proteins--suppressors of apoptosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508664200

21 January 2018

The CD95(APO-1/Fas) DISC and beyond

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508664200

21 January 2018

Apoptosis signaling by death receptors.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508664200

21 January 2018

Small-molecule antagonists of apoptosis suppressor XIAP exhibit broad antitumor activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508664200

21 January 2018

Identifiers

10.1074/JBC.M508664200

1 reference

Europe PubMed Central

PubMed publication ID

26 December 2017

http://europepmc.org/abstract/MED/16461771

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

26 December 2017

http://europepmc.org/abstract/MED/16461771

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q46930696&oldid=2138458535"