(Q46970691)

27 December 2017

title

EGFR and beta1 integrins utilize different signaling pathways to activate Akt. (English)

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27 December 2017

author name string

Teet Velling

series ordinal

1

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27 December 2017

Anne Stefansson

series ordinal

2

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27 December 2017

Staffan Johansson

series ordinal

3

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27 December 2017

language of work or name

English

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publication date

29 August 2007

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27 December 2017

Experimental Cell Research

published in

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27 December 2017

volume

314

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27 December 2017

page(s)

309-316

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27 December 2017

issue

2

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27 December 2017

Domain swapping used to investigate the mechanism of protein kinase B regulation by 3-phosphoinositide-dependent protein kinase 1 and Ser473 kinase

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Direct identification of tyrosine 474 as a regulatory phosphorylation site for the Akt protein kinase

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Interaction between Src and a C-terminal proline-rich motif of Akt is required for Akt activation

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Protein kinase CK2 phosphorylates and upregulates Akt/PKB.

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The platelet-derived growth factor beta receptor triggers multiple cytoplasmic signaling cascades that arrive at the nucleus as distinguishable inputs

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The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

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A specific product of phosphatidylinositol 3-kinase directly activates the protein kinase Akt through its pleckstrin homology domain.

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Stimulation of beta1 integrins on fibroblasts induces PDGF independent tyrosine phosphorylation of PDGF beta-receptors

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Integrins induce activation of EGF receptor: role in MAP kinase induction and adhesion-dependent cell survival

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7 January 2021

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beta1-Integrins induce phosphorylation of Akt on serine 473 independently of focal adhesion kinase and Src family kinases

7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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Phosphorylation of tyrosine 397 in focal adhesion kinase is required for binding phosphatidylinositol 3-kinase

7 January 2021

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Src kinase activation by direct interaction with the integrin β cytoplasmic domain

7 January 2021

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A requirement for caveolin-1 and associated kinase Fyn in integrin signaling and anchorage-dependent cell growth

7 January 2021

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alpha5beta1 integrin protects intestinal epithelial cells from apoptosis through a phosphatidylinositol 3-kinase and protein kinase B-dependent pathway

7 January 2021

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The alpha5beta1 integrin selectively enhances epidermal growth factor signaling to the phosphatidylinositol-3-kinase/Akt pathway in intestinal epithelial cells

7 January 2021

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SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity

7 January 2021

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10.1016/J.YEXCR.2007.08.018

7 January 2021

Identifiers

DOI

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27 December 2017

PubMed ID

17910952

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27 December 2017